CC BY
15B-O-1
Photothermal effect in skin tumor with embedded silicon nanoparticles: numerical simulation
O.I. Sokolovskaya1, S.V. Zabotnov1, L.A. Golovan1, P.K. Kashkarov1, A.V. Khilov21, D.A.
Kurakina2, E.A. Sergeeva21, M.Yu. Kirillin1
1-Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia 2-Institute of Applied Physics RAS, Nizhniy Novgorod, Russia
e-mail: oi.sokolovskaja@physics.msu.ru
Photothermotherapy (PTT) techniques are based on using inorganic nanomaterials as a thermal coupling agents for a biological sample [1]. Silicon is material of high biocompatibility, bioavailability, biodegradability and low toxicity [2]. In this study nodular basal cell carcinoma (BCC) laser heating in presence of silicon nanoparticles is simulated for temperatures corresponding to mild hyperthermia regimes (42-43 0C). The study was performed for nanoparticles obtained by picosecond laser ablation of silicon nanowires in water and ethanol. The optical properties of suspensions were obtained through Mie calculations based on the atomic force microscopy data on particles size distribution.
We used Monte Carlo simulation method to obtain volumetric density of absorbed energy distribution as a result of light absorption from continuous laser source. Then we solved time-dependent bioheat equation through COMSOL® Multiphysics package. Simulations revealed that irradiation by moderate laser powers of human skin containing carcinoma with size of several millimeters in presence of silicon nanoparticles formed by pulsed laser ablation of low-doped silicon nanowires in water in tumor tissue allows to reach the temperature of 42oC in all tumor volume, while without nanoparticles at the same irradiation conditions the full heating of considered carcinoma is not possible. The optimal laser powers were 100 mW for beam of 5.1 x 5.1 mm2 and 170 mW for beam size of 10 mm2, and the irradiation time was 600 sec. At these power values the maximal increase in heating efficiency of tumor tissue was 1.5°C and 1°C, respectively. This work was supported by Russian Science Foundation (grant №19-12-00192)
[1] C. Hong, J. Lee et. al., Porous silicon nanoparticles for cancer photothermotherapy, Nanoscale research letters, vol.6, 321 (2011)
[2] Y. Park, J. Yoo, M. H.,Kang, W. Kwon, , & J. Joo, Photoluminescent and biodegradable porous silicon nanoparticles for biomedical imaging. Journal of Materials Chemistry B, vol. 7, 6271-6292. (2019).
