CC BY
4DOI 10.24412/cl-37136-2023-1-56-56
PHOTODYNAMIC FOR MICROBIOLOGICAL CONTROL AND BREAKDOWN OF
RESISTANCE TO ANTIBIOTIC
VANDERLEI S. BAGNATO
Instituto de Fisica de Sao Carlos - Universidade de Sao Paulo - BRAZIL Biomedical Eng. - Texas A&M University - College Station - Texas - USA
vander@,ifsc .usp.br http ://cepof.ifsc.usp.br
ABSTRACT
The use of photodynamic action to combat microorganisms is a well-established field of great importance for microbiological control, including antibiotic-resistant bacteria. In situations where the basic elements for the relationship of the photodynamic annihilation of microorganisms can be applied: light, oxygen and photosensitization, the treatment with photodynamic reaction for microbial elimination works very well. In cases where these elements cannot be assured, we still depend on the action of the antibiotic. In this work, we demonstrate the use of oxidative stress caused by photodynamic action to reduce antibiotic resistance in resistant bacteria, allowing the antibiotic action to be reestablished.
Many different aspects of this demonstration and experimental realization are presented in this work. That includes the possibility to detect spectroscopically the bacteria resistance previously to treatment. This work has the participation of K. Blanco, T. Quatrine, J. M. Soares, Claudia P. Patino . Support from FAPESP, CNPq -Brazil and program CEPRIT - Texas - USA.
REFERENCES
[1] J. M.Soares et al - Physiochemical mechanisms of bacterial response in photodynamic potentiation of antibiotic effecs - Scientific Report 2022, 12, 2146
[2] J. A. Willis et al - Breaking down antibiotic resistance in methicillin-resistant S. Aureus - Proceeding of the National Academy of Science - PNAS 2022, 119, 2208378119
