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Abstracts. PHYTOPHARM 2017
We investigated the effects of Sanguisorbae Radix extract (SRE) on skin thickness, skin weights, histophathological changes and cytokine productions in dimitrofluorobenzene (DNFB)-induced CD mice.
Topical application of SRE effectively inhibited enlargement of skin thicknesses (P < 0.05, 27.8% of inhibition compared to CTL) and weights (P < 0.05, 22.4% of inhibition compared to CTL). SRE treatment also inhibited epidermal hyperplasia, hyperkeratosis and immune cell infiltration induced by DNFB in inflamed tissues in CD mice. Moreover, treatment with SRE suppressed the increase in the levels of TNF-a (P < 0.01, 38.9% of inhibition compared to CTL)
and IFN-y (P < 0.05, 31.9% of inhibition compared to CTL) respectively. These data suggest that SRE acts as an anti-inflammatory agent that decreases the production of TNF-a and IFN-y, resulting in ameliorating histopathological abnormalities in inflamed skin tissues.
References:
1. Abrahaamson MJ, 2004. Arch. Intern. Med, 164:486491.
2. Stand E, Baumgartl HJ, Füchtenbusch M, Stem-plinger J, 1999. Diabetes. Obes. Meta., 1:215-220.
3. Hanefeld M. 1998. J. Diabetes Complications, 12:228237.
PHENYLPROPANOIDS FROM IXERIS DENTATA AND THEIR NEURAMINIDASE INHIBITORY ACTIVITY
© Seon Ju Park, Jun Hyung Park, Seung Hyun Kim
College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Korea
Ixeris dentata (Asteraceae) is well-known for edible wild vegetable in Asia, which is distributed throughout East Asia [1]. Using various chromatographic methods, seven phenylpropanoid glycosides (1-7), two flavonoid glycoside (8, 9) and one alkene glycosides (10) were isolated. Their structures were determined as chlorogenic acid (1), 3,5-dicaffeoylquinic acid (2), 4,5-dicaffeoylquinic acid (3), citrusin C (4), 4-allyl-2,6-dimethoxyphenol glucoside (5), diydrosyringin (6), 3-(4-hydroxy-3,5-dimethoxyphenyl) propyl p-D-glucopyranoside (7), apigenin 7-O-p-D-glucoside (8), luteolin 7-O-p-D-glucoside (9) , and (Z)-3-hexenyl-p-D-glucopyranoside (10), respectively, by spectroscopic methods including NMR and MS. All
the isolated compounds were tested for their ability to inhibit neuraminidase. Two quinic acid derivatives (2, 3) significantly inhibited neuraminidase activity, which was comparable to the positive control, mangiferin [2]. In addition, structure-based virtual screening against neuraminidase showed.
References:
1. Barbero F, Maffei M. 2016. Plant Specialized Metabolism: Genomics, Biochemistry, and Biological Functions. United Kingdom: Taylor & Francis Incorporated.
2. Karar MGE, Matei MF, Jaiswal R, Illenberger S, Kuhnert N. 2016. Food Funct. 7:2052-2059.
Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] vol. 15/2017/supplement 1
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