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с плацебо (включая перианальную форму заболевания и септические осложнения). Метаанализ 6 испытаний, изучавших результативность антимикобактериальной терапии, показал, что только в 2 исследованиях, предполагавших использование КС для индукции ремиссии, наблюдалось влияние на течение заболевания. Другое РКИ (n=216), проведенное в Австралии, продемонстрировало, что тройная терапия в сочетании с КС улучшает клинический ответ к 16-й нед лечения; но если антимикобактериальная терапия без КС продолжалась на протяжении двух лет, у пациентов, ответивших на лечение, клиническая картина заболевания оставалась неизменной в течение 3 лет [6]. Результаты недавно опубликованного исследования подтвердили, что рифаксимин в дозе 800 мг/сут превосходит плацебо в индукции ремиссии при БК с низкой/умеренной активностью; однако более низкие или высокие дозы препарата оказались неэффективными, а уточняющие клинические исследования до сих пор не проведены.
Использованные источники:
1. Болезнь Крона (диагностика и лечение): Авт.-сост.: Барановский А.Ю., Щукина О.Б./ Комитет по здравоохранению Правительства Санкт-Петербурга. - СПБ.: Изд-во «Наука и техника», 2010. - 190 с.
2. Хорошилов И. Е. Энтеральное питание в гастроэнтерологии: вчера, сегодня, завтра // Фарматека. - 2012. - № 14. - P. 32-36
3. Ruemmele F.M. (2014) Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric crohn's disease. Journal of Crohn's & colitis, vol. 8, no 10, pp. 1179-207
УДК 618.2
Гайраткызы Д. магистр-преподавател ь Международный казахско-турецкий университет им. Х.А. Ясави
Казахстан, г. Туркестан ОСОБЕННОСТИ СТАНОВЛЕНИЯ РЕПРОДУКТИВНОГО ЗДОРОВЬЯ ДЕВОЧЕК И ДЕВОЧЕК-ПОДРОСТКОВ, ЖИВУЩИХ В ЭКОЛОГИЧЕСКИ НЕБЛАГОПРИЯТНЫХ РЕГИОНАХ
КАЗАХСТАНА
Аннотация: Низкий уровень физического и сексуального развития девочек и девочек-подростков, живущих в экологически неблагоприятном регионе, был определен по сравнению с обычными показателями.Частота появления экстрагенитальной патологии составляла 72% у девочек и девочек-подростков, которые живут в экологически неблагоприятном регионе, нарушение их менструального цикла составляло 63,2%, а воспаление половых органов - 59%.
Ключевые слова: девочки-подростки, экология , репродуктивное здоровье,экстрагенитальная патология, нарушения менструального цикла.
"Мировая наука" №1(10) 2018 science-j.com
UDC 618.2
Gayratkyzy D., Master-Teacher International Kazakh-Turkish University named H.A. Yasavi
Turkestan, Kazakhstan
PECULIARITIES OF THE FORMATION OF REPRODUCTIVE HEALTH OF GIRLS AND GIRLS-TEENAGERS LIVING IN ECOLOGICALLY UNBEARABLE REGIONS OF KAZAKHSTAN Annotation: The low level of physical and sexual development of girls and teenage girls who live in ecological unsuccessful region has been determined in comparison with usual indicators. The frequency of appearance of extragenital pathology was 72% at the girls and the teenage girls who live in ecological unsuccessful region, the violation of their menstrual cycle was 63,2%, and the inflammation of genitals was 59%.
Keywords:ecology, teenage girls, reproductive health, extra genital pathology, violation of a menstrual cycle.
Parameters of physiological development of the girls and teenage girls who livein ecologicalunsuccessful region were defined. By results of the research it is revealed high parameters by age, puberty growth has been registered after the age of 10-year-old , it has become clear that progressive growth continues to the 15-year- old period[1].
The physical development is characterized by increase in weight at 7-10 -year-old (+10 kg) in comparison with their growth. Despite it middle indicators on growth and the weight of the girls and teenage girls that live in the Turkestan region by physical development belong to normal range type[2].
With the help of Tanner scale we investigated the level of development of the mammary gland at the girls and teenagers that live in the Turkestan region.The research has shown the low level of development of mammary glands at girls in the region. The level of development of mammary gland among 7-11- year-old girlswas normal with usual indicator Ma-1-41,7 % , but among 12-15-year-old it was Ma-2-46,9 % which shows low level in comparison with standard indicators. We have also found out low indicator Ma-3-57,1% among 16-19 year-old teenagers [3].
By questioning we have defined age at menarche of the beginning time of the menstrual cycle at girls and teenage girls during the clinical trial: middle age of menarche has made 13,2 ± 1,3 ageat girls and teenage girlsin the region. Also it has been revealed early and late age of menarche here. By results 26 girls had early age atmenarche which has made 8,7%, late age at menarche was at 17,6% of girls.
For the purpose of an evaluation of somatic health of the studied girls we have determined the frequency of appearance of extragenital pathology. By results of research it has been determined low level of somatic health of girls and teenage girlsthat live in ecological unsuccessful Turkestan region. Among the studied girls the frequency of appearance of extragenital pathology has made 72%, and the
number of healthy girls has made 28% [4].
At research of structure of extragenital pathology we have received the following results: existence of a number of several diseases, i.e. extragenital pathology was 42,1%, among the diseases of blood system: anemia was 35,2%, disease of an urinary system: pyelonephritis - 26,7%, digestive tract diseases: gastritis-15,7 %, disease of respiratory tract - 8,9%, diseases of endocrine system-2,7 %, allergic diseases - 1,2%, diseases of nervous system - 0,96%, diseases of cardiovascular system was 0,86 %. We also have determined the frequency of violation of the menstrual cycle at girls and teenage girlsthat live in ecological unsuccessful region. 36,8% girls were healthy, 63,2% from the participating girls in a research had the violation of menstrual cycle. It was higher than usual. By results of the research on violation of menstrual cycle we have defined the following: the girls haddysmenorrhea, i.e. during the period of menstrual cycle they had pains, nausea, vomiting, anxiety. The indicator of these complaints were 66,4%, hypomenstrual syndrome -19%, juvenile hemorrhage- 15%, amenorrheawas of 4,5% [5]. Frequency of appearance of inflammatory diseases of genitals at girls and teenage girls that live in ecological unsuccessful Turkestan region has made 59%, healthy girls have made 41%.
Conclusion
Parameters of physical and sexual development of girls and teenage girls that live in ecological unsuccessful region have been determined. The problem of somatic health of girls and teenage girls that live in ecological unsuccessful region is a huge part of medicine,the extragenital pathology makes 72%. The frequency of appearance and structure of gynecologic diseases of girls and teenage girls that livein ecological unsuccessful region have been determined. It was also defined the age of menarche of girls and teenage girls that live in this region.
Literature:
1. R.G.Nurkhasimova, A.Zh.Daniyarova, A.B.Muratbayev, A.Sh.Bakhtiyarov, Zh.E.Torkoauytova Structure of gynecological diseases of teenage girls living in the Turkestan region. 2013. 80 pp.
2. Baranov A.N. The ghost features of physical and sexual development of girls in the conditions of the European North. News. Ros Associate. 1997, 2: 49-51.
3. Ushakova G.A., Elgina S.I., Nazarenko M.Yu. Reproductive health of a modern population. Akush. And gin. 2006, 1: 34-39.
4. Bogdanova E.A. Inflammatory diseases of the vulva and vagina in girls. Gynecology. 1999, Vol. 1; 3: 46-54.
5. Ankirskaya A.S. Nonspecific vaginitis. Medicine for all. 2000; T.2; 21-27.
