CC BY
18
Биорадикалы и Антиоксиданты 2016 Том 3, №3
154
ОЗОНОТЕРАПИЯ В ХИРУРГИИ
А. Schwartz
OZONE AND OZONATED GROWTH FACTORS IN THE TREATMENT OF DISC HERNIATION AND DISCARTROSIS OF LUMBAR SPINE
Clínica Fiorela, Madrid, Spain
The management of the disc herniation and its complications through highly invasive surgical techniques has drawbacks including the high number of adverse effects. Intradiscal injection with ozone has shown high therapeutic efficacy and the use of growth factors derived from platelets is increasingly used in tissue regeneration. The present study aimed to demonstrate the efficacy and safety of ozone on the herniated disc and the healing and restorative effect of growth factors on degenerative disc syndrome. A prospective, single-center, nonrandomized study was carried out involving 60 patients in an age range of 35-82 years old diagnosed with severe lumbo-sciatica, Visual Analog Scale (VAS) 7-8. The patients were infiltrated 5-8 mL of ozone at 25-35^g/mL intradiscal, 1mL of concentrated growth factor (CGF) and 0.5 mL of CD34+ cells. Foraminal and facet injection was done with 10 cc of ozone at 10 |ig/mL, 2 cc CGF and sacro-hiatal injection with 15 mL of ozone at 15^g/mL plus 1 mL of CGF. Evaluation of the patients was followed by monitoring clinical symptoms, EVA (visual analogue scale) assessment, and MRI (Magnetic Resonance Imaging) methods. The results showed significant improvement (p<0,01) 90% of complete resolution with EVA 0-2 at 4 and 6 months, and MRI showed resolution of the hernia and rehydration of damaged discs. The remaining 10% showed a partial resolution. The 5% percent of these patients reported adverse reactions (2 patients with mild transient headache and one with pneumocephalus resolved at 48 h). These results demonstrated the efficacy and safety of the procedure in this type of pathology.
Key words: CGF, PRP, Ozone, Intradiscal injection, CD43+, growth factors, disc-hernia, disc degenerative syndrome
