CC BY
8P-III
PLENARY SESSION
Optical Coherence Elastography: Past, Present, and Future
Vladimir Yu. Zaitsev
Institute of Applied Physics, RAS, Nizhniy Novgorod, Russia vyuzai@ipfran.ru
Over two decades passed after the seminal work by J. Schmitt in which, by analogy with medical ultrasound, he proposed Optical Coherence Elastography (OCE) for evaluation of microscopic strains and characterization of elastic properties of biological tissues. However, only during ~5-7 recent years there appeared practically workable realizations OCT-based imaging of strains, as well as quantitative OCT-based techniques for assessment of elastic properties of biological tissues based on the compression principle and measurements of shear-wave velocities.
These techniques have demonstrated previously unavailable prospects for various applications, where imaging of strains is required (from fairly rapidly varying thermo-mechanical strains, osmotically-induced strains to slow strains due to drying, relaxation, etc.)
Furthermore, quantitative assessment of tissue elasticity beyond conventional linear paradigm has become possible. For oncologic applications, novel possibilities have been demonstrated, in particular feasible in vivo morphological segmentation of tumors with an accuracy very close to results of morphological segmentation of conventional histological images, the obtaining of which requires laborious and invasive procedures. In application to freshly excised samples of breast-cancer tissues, OCT-based elastography opened previously unavailable possibilities of accurate assessment of clean resection boundary. Furthermore, intraoperatively feasible OCE-based differentiation of molecular/morphological subtypes of tumors has been demonstrated. The report gives an overview of these topics.
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