Opioid peptides defend from the traumatic shock Текст научной статьи по специальности «Клиническая медицина»

STH MULTIDISCIPLINARY INTERNATIONAL

Conference of Biological Psychiatry

«Stress and Behavior»

Proceedings of the 9th International Multidisciplinary Conference «Stress and behavior» Saint-Petersburg, Russia, 16-19 May 2005 Editor: Allan V. Kalueff, PhD

CONFERENCE ABSTRACTS 1. PSYCHOPHARMACOLOGY

OPIOID PEPTIDES DEFEND FROM THE TRAUMATIC SHOCK

V.N. Tsygan, E.K. Akperov Military Medical Academy, St. Petersburg, Russia Enkephalines, endorphines and other opioid peptides are neurotransmitters and neuromodulators of sensibility on the all levels of pain formation and stress-limiting systems. During the combat conditions 52 patients have been studied after severe injuring, control group consisted of 15 servicemen. The content of ligands of P-endorphine and enkephaline receptors has been studied in the cerebrospinal fluid on the 1st-3rd day after the injury by radioimmune procedure. The servicemen’s chronical stress was accompanied by activation of endogenous opiod system. At the same time the opiod system activation led to the cardiovascular and respiratory activity disorders during the shock.

Psychopharmacol. Biol. Narcol. 2005. Vol. 5, N 2. P. 889 Psyhopharmacology & biological narcology

ISSN 1606-8181