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0New generation of nanostructures with laser-controllable biological and luminescence properties
G. Bikbaeva1*, A. Pilip2, A. Egorova3, I. Kolesnikov4, D. Pankin4, V. Medvedev1, K. Laptinskii56, A. Vervald6, T. Dolenko6, A. Manshina1
1-Institute of Chemistry, St. Petersburg State University, St. Petersburg 198504, Russia 2- St. Petersburg Federal Research Center of the Russian Academy of Sciences (SPC RAS), Scientific Research Centre for Ecological Safety of the Russian Academy of Sciences, St. Petersburg 197110, Russia 3- St. Petersburg State Technological Institute (Technical University), St. Petersburg 190013, Russia 4- Center for Optical and Laser Materials Research, St. Petersburg State University, St. Petersburg 198504,
Russia
5- Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow 119991, Russia 6- Skobeltsyn Institute of Nuclear Physics, M. V. Lomonosov Moscow State University (SINP MSU), Moscow
119991, Russia
Design of hybrid nanostructures by combination of different components is a promising strategy to obtain advanced functional materials [1]. For example, incorporation of photoswitchable fragment as component of hybrid nanomaterial provides opportunity of its remote control by laser irradiation. By now hybrid nanostructures with photoswitchable-enhanced functional properties have been demonstrated as optical logic elements, optoelectronic devices, drug delivery, etc [2].
Here we present unique hybrid nanostructures based on photo-switchable and bioactive phosphonate molecules and luminescent carriers (oxide nanoparticles doped with rare earth ions LaVO4:Eu3+, carbon quantum dots). The study of the obtained hybrids with luminescent spectroscopy, IR spectroscopy and IPC-micro analysis of neurotoxins revealed a pronounced effect of laser radiation on the optical and biological properties of new objects. Hybrids demonstrate not only properties of initial components - luminescence and photo-switchable butyrylcholinesterase inhibition, but also strong effect of carrier nature on bioactivity, and photo-switchable effect on luminescence properties [3]. Thus, the presented hybrid nanomaterials were found to demonstrate a remarkable combination of all-in-one properties important for photopharmacology: (i) bioactivity toward butyrylcholinesterase inhibition, (ii) strong change of inhibition degree as a result of laser irradiation, luminescence as an indicator of (iii) bioactivity state, and of (iv) spatial localization on the surface of a sample. The functionality of the hybrids has been demonstrated both in vitro and in vivo on various biological test objects.
This work was supported by RSF project 22-13-00082. Authors are grateful to "Centre for Optical and Laser materials research", Research Park of Saint Petersburg State University for technical support. Authors are grateful to Interdisciplinary Scientific and Educational School of Lomonosov Moscow State University "Photonic and Quantum technologies. Digital medicine".
[1] F. Cardano, M. Frasconi, S. Giordani, Photo-Responsive Graphene and Carbon Nanotubes to Control and Tackle Biological Systems, Front. Chem. 6, (2018).
[2] X. Zhang, L. Hou, P. Samori, Coupling carbon nanomaterials with photochromic molecules for the generation of optically responsive materials, Nat. Commun. 7, 11118 (2016).
[3] G. Bikbaeva, et al, All-in-One Photoactivated Inhibition of Butyrylcholinesterase Combined with Luminescence as an Activation and
Localization Indicator: Carbon Quantum Dots@Phosphonate Hybrids, Nanomaterials 13, 2409 (2023).
