CC BY
43
UDC 613.155.6:539.2-022.532]-057
A.I. Sevalnev 1, L.P. Sharavara 1, A.V. Kutsak1, O.O. Nefodov 2, O.A. Zemliynyi2 K.I. Pisarevskyi2, O.S. Shevchenko 2
Zaporizhzhya State Medical University 1
Department of General Hygiene and Ecology
Mayakovsky ave., 26, Zaporizhzhia, 69035, Ukraine
SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine» 2
Department of General and Clinical Pharmacy
Department of clinical anatomy, anatomy and operative surgery
V. Vernadsky str., 9, Dnipro, 49044, Ukraine
3anopisbKuü державний медичний ушверситет 1
кафедра загально'1' гтени та екологи
(зав. - к. мед. н., доц. А.1. Севальнев)
пр. Маяковського, 26, Запорiжжя, 69035, Украгна
ДЗ «Днтропетровська медична академiя МОЗ Украти» 2
кафедра загально'1' та клШчно! фармаци
(зав. - д. фарм. н., проф. О.А. Подплетня)
кафедра клiнiчно'i анатома, анатомИ i оперативно'1' хiрургii
(зав. - д. мед. н., доц. О. О. Нефьодова)
вул. В. Вернадського, 9, Днтро, 49084, Укра'та
e-mail: saravaralarisa@gmail.com
Цитування: Медичш перспективы. 2020. Т. 25, № 3. С. 169-176
Cited: Medicniperspektivi. 2020;25(3):169-176
Key words: nanoparticles, fine fractions, air of working zone, occupational risk
Ключовi слова: наночастинки, dpi6noducnepcni фракцИ, повтря робочо'1 зони, професшний ризик
Ключевые слова: наночастицы, мелкодисперсные фракции пыли, воздух рабочей зоны, профессиональный
риск
Abstract. Nanoparticles in the air of the working zone as a risk factor for the health of workers of various industries. Sevalnev A.L, Sharavara L.P., Kutsak A.V., Nefodov O.O., Zemliynyi O.A., Pisarevskyi K.I., Shevchenko O.S.
Purpose: analysis of scientific literature, summarizing data on domestic and foreign experience of assessing the determination of nanoparticles in the air of the working zone as a risk factor for the health of workers of various industries. The article analyzes the literature data on the study of the content of fine dust and nanoparticles in the atmospheric air and air of the working zone of different industries. Numerous studies indicate that fine dust is contained in the emissions of many industrial enterprises. According to the World Health Organization by level of impact on human health, suspended particles in the air and especially in the air of the working zone belong to the priority pollutants. Evaluation of the dust content in the air of large industrial cities is particularly relevant, because of a large number of sources of dust emissions of various origins in urban areas. Various technological processes contribute to the formation offine dust and nanoparticles which pollute the ambient air and the air of the working zone. Data on the negative impact offine dust and nanoparticles on health of workers are presented. Attention is paid to the problem of hygienic assessment of nanoscale dust content in the working zone air. The obtained results indicate that today the issues of studying the physicochemical properties of nanoparticles, their toxicity to the body, analysis of potential risks to humans, the development of an effective and reliable system for monitoring ultrafine particles in the environment and the production environment are still relevant as for informing employees about the risks involved, reducing and preventing harmful effects on humans. The potential negative effects on workers' health determine the need and opportunity for further research in this area.
Реферат. Наночастинки в noBirpi робочоТ зони як фактор ризику для здоров'я працюючих у рпних галузях виробництва. Севальнев АЛ., Шаравара Л.П., Куцак А.В., Нефьодов О.О., Земляний О.А., Писаревський К.1., Шевченко O.C. Мета роботи: аналiз науково'1 лiтератури для узагальнення даних про втчизняний i зарубiжний досвiд оцтки визначення наночастинок у повiтрi робочо'1 зони як фактора ризику для здоров'я працiвникiв рiзних галузей виробництва. У статтi проведено аналiз лтературних даних щодо до^дження
https://doi.org/10.26641/2307-0404.20203.214859
NANOPARTICLES IN THE AIR OF THE WORKING ZONE AS A RISK FACTOR FOR THE HEALTH OF WORKERS OF VARIOUS INDUSTRIES
вмiсту дрiбнодисперсного пилу та наночастинок в атмосферному nовiтрi та nовтрi робочоХ зони р1зних галузей виробництва. Численнi дослiдження свiдчать про те, що дрiбнодисперсний пил мктиться у викидах багатьох промислових тдприемств. За рiвнем впливу на здоров'я людини зваженi частинки в атмосферному повiтрi й особливо в повiтрi робочоХ зони Всесвтньою органгза^ею охорони здоров'я вiдносяться до прюритетних забруднювачiв. Особливо актуальна оцiнка вмiсту пилу в повiтрi великих промислових мкт, осюльки на урбан1зованих територiях знаходитися велика юльюсть джерел пилових викидiв р1зного походження. Р^зномантш технологiчнi процеси сприяють утворенню дрiбнодисперсного пилу i наночастинок, як забруднюють атмосферне повтря та повтря робочоХ зони. Приводяться дат щодо негативного впливу дрiбнодисперсного пилу та наночастинок на здоров'я людини та працюючих. Придтено увагу nроблемi гтетчноХ оцтки вмiсту пилу нанорозмiрного дiаnазону в nовiтрi робочоХ зони. Одержанi результати свiдчать про те, що на сьогодш все ж таки залишаються актуальними питання вивчення фiзико-хiмiчних властивостей наночастинок, Хх токсичностi для орган1зму, анализу потенцшних ризиюв для людини, розробки ефективноХ та достовiрноХ системи монторингу ультродисперсних частинок у навколишньому та виробничому середовищi, обов 'язкового тформування працюючих про наявнi ризики, зменшення та профтактику шюдливого впливу на людину. Можливi негативш на^дки для здоров 'я працюючих зумовлюють необхiднiсть i доцшьнкть подальших до^джень у цт галузi.
Today, one of the leading directions in the development of world technological progress is work on the use of nanotechnology in industry and the creation of promising nanomaterials. In this regard, a large number of materials appear in different industries, which in their composition have particles of the nanoscale range (less than 100 nm). Nanotechnology has not only obvious advantages, but also carries a potential danger to human health and the environment. The use of nanotechnology and the emergence of new nanomaterials in industry require a detailed assessment of the potential risks associated with their use. The study of occupational risks in contact with humans and biological objects of the environment with nanoparticles is an urgent and important task of occupational medicine today.
Purpose: to analyze the scientific literature, to summarize data on domestic and foreign experience in assessing the determination of nanoparticles in the air of the working zone as a risk factor for the health of workers in various industries.
According to the World Health Organization by the level of impact on human health, suspended particles in the air and especially in the air of the working zone belong to the priority pollutants. The undoubted danger to human health is represented by particles of the PMi0 and PM25 fraction, which have the ability to penetrate the thoracic section of the respiratory system and cause a negative effect on human health. The presence of nanoparticles in the atmospheric air of populated areas and in the air of the working zone of various industries is proved by the data of domestic and foreign studies [4, 5, 15, 21, 25, 27, 40]. Numerous studies have proved the negative effect of dust on human health [7, 34, 37, 39, 44], especially on the cardiovascular system [13, 29, 30, 38, 43], respiratory system [2, 21, 33, 42, 43], contributing to the increase in mortality from cardiovascular and respiratory diseases, lung cancer [1, 8, 13].
According to research of scientists from different countries, suspended particles formed as a result of motor vehicles emission, cause an increase in mortality by 6% among different population groups and increase the total amount of cases of chronic bronchitis and asthma attacks in adults and children as well.
Evaluation of the dust content in the air of large industrial cities is particularly relevant, because of a large number of sources of dust emissions of various origins in urban areas: the operation of automobile engines, the movement of cars along the roads, the burning of solid fuels, and various industrial enterprises.
Numerous studies indicate that dust is contained in the emissions of many industrial enterprises: of ferrous and non-ferrous metallurgy, construction, mechanical engineering, electrical engineering. Technological processes at these industrial enterprises result in the formation of fine dust [3, 18, 16, 19, 21, 22, 27, 41] and, accordingly, the formation of particles of the nanoscale range is possible.
The technological processes of crushing, grinding, mixing, storage and transportation of bulk materials, melting contribute to the formation of fine dust and dust with an aerodynamic size of less than 10 microns, which are not captured by dust cleaning plants and contribute to the pollution of atmospheric air and air of the working area with solid particles of different sizes, including ultrafine [14, 18, 17, 23, 35].
The concentrations of suspended particles in the air of the working zone are much higher than the concentrations of these particles in the atmospheric air due to the close proximity to the source of formation and the use of processes of solid materials processing. Depending on the mechanisms of formation, aerosols of disintegration, formed as a result of processing of solid materials (cutting, crushing, grinding, grinding, etc.), and condensation aerosols, formed as a result of cooling of vapors (melting, welding of metal) are distinguished.
Numerous studies indicate that nanoparticles cause a negative effect on the worker's health and can cause changes in the human body, in particular, changes in the immune system [36], development of cancer [40], they affect the respiratory system [31], cause diseases of the cardiovascular system and increase the risk of mortality from coronary heart disease [28, 32], increase the incidence of the urogenital and digestive system diseases, affect the central nervous system, cause diseases of locomotor apparatus [16, 38].
Unfortunately, nowadays, the hygienic assessment of dust content in the air of the working zone does not reflect such characteristics of dust as the particle size, their shape, surface area, the number of particles; this does not allow to fully determine the amount of potential risk to human health
Today, in Ukraine and worldwide, there are no values of maximum permissible concentrations (MPC) for nanoscale particles of different chemical composition, which is a serious problem in the assessment of the level of occupational risk [12, 33]. In the case of hygienic assessment of the level of exposure of nanoparticles in the air, foreign scientists propose to use "test levels", namely for metals and biologically stable dispersed nano-particles with a density of >6000 kg/m3, the quantitative concentration of particles in the range 1-100 nm should not contain more than 20 000 particles/cm3, for biologically stable dispersed nanoparticles with a density of <6000 kg/m3 - more than 40 000 particles/cm3. However, for some nano-materials, there are maximum allowable concentrations determined by leading experts of the US Institute of Occupational Health and Safety (TiO2 -0,3 mg/m3, carbon nanotubes and nanofibers - 0,007 mg/m3), and for other substances it is recommended to use safety factors recommended by British Institute for Standards for Risk Assessment [11, 12].
Today different scientists worldwide actively conduct research of influence of nanoparticles on the state of health of humans [34] and determination of their presence in the air of the working zone. So, by the group of scientists content of nanoparticles in the air of the working zone of workers, at a receipt and production of nanoparticles of different chemical composition for industry was investigated. As a result of the study, it was found that the available concentrations of nanoparticles in the air of the working zone can exceed the calculated MPC according to safety factors for nanomaterials, even if there is no excess of the existing MPC for these substances in the usual form. Also, the results of the study indicate the presence of a background concentration of nanoparticles before work and the
presence of other chemical elements not related to the process; this may be a consequence of internal and external factors, that also increases the level of risk for workers [9, 10, 16, 20, 24, 26].
According to the research, of Varivonchik D.V. and others a hygienic assessment of the working conditions of dentists and dental technicians was carried out as a result of which it was established that they are exposed to dust of the nanoscale range of about 14 metals that make up the materials they work with. The recommended standards for nanodispersed dust of II-III hazard classes were exceeded by 4,8 times according to the Hygienic classification of working conditions [5, 6].
According to the results of studies of Movchan N.A. et al.at the Institute of Occupational Medicine of the Academy of Medical Sciences, it was found that lead has a high level of emissions of the nanoparticles of this element into the air of the working zone. Almost 90 % of all sizes have sizes from 1 to 100 nm, and their values in fractions of 510 nm, 10-15 nm and 15-20 nm, the development and implementation of preventive measures are required to improve the working conditions of workers. area [15].
A large number of studies, which confirm the presence of nanoparticles in the air of the working zone of various industries and possible negative consequences for the health of workers, necessitates the expediency of their research, namely, the physicochemical and toxicological properties of nanoparticles of various chemical composition, their effect on the human body and the development of scientific justification of the hygienic standard of these substances in the air of the working area.
CONCLUSIONS
1. Numerous studies of scientists indicate that fine dust is contained in the emissions of many industrial enterprises. Various technological processes contribute to the formation of fine dust and nanoparticles, which pollute the ambient air and the air of the working zone.
2. According to the World Health Organization by the level of impact on human health, suspended particles in the air and especially in the air of the working zone belong to the priority pollutants. Numerous studies indicate that nanoparticles cause a negative effect on the worker's health and can cause changes in the human body, in particular, changes in the immune system, development of cancer, they affect the respiratory system, cause diseases of the cardiovascular system and increase the risk of mortality from coronary heart disease, increase the incidence of the urogenital and digestive system diseases, affect the central nervous system, cause diseases of locomotors apparatus.
3. Analysis of literary sources suggests that today the priority scientific, research in the field of nanoparticles including medical, should be considered:
- the study of the physicochemical properties of nanoparticles, their toxicity to the body;
- analysis of potential risks for humans, the development of an effective and reliable system for
controlling ultrafine particles in the surrounding and production environment;
- development of a system for mandatory informing employees about existing risks in order to reduce and prevent harmful effects on humans.
Conflict of interests. The authors declare no conflict of interest.
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СПИСОК Л1ТЕРАТУРИ
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Стаття надшшла до редакцп 15.01.2020
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https://doi.Org/10.26641/2307-0404.2020.3.214860
ВИВЧЕННЯ ТА АНАЛ1З СИТУАЦП ЩОДО СПОЖИВАННЯ Д1СТИЧНИХ ДОБАВОК НАСЕЛЕННЯМ УКРАШИ
ДУ «1нститут громадського здоров'я iM. О.М. Марзеева НацюнальноЧ академи медичних наук Укра'ти»
(дир. - д. мед. н., проф., академк НАМНУА.М. Сердюк)
вул. Попудренко, 50, Кшв, 02094, Украна
State Institution «O.M. Marzeiev Institute for Public Health
of the National Academy of Medical Science of Ukraine»
Popudrenko str., 50, Kyiv, 02094, Ukraine
e-mail: helensi@i.ua
Цитування: Медичш перспективы. 2020. Т. 25, № 3. С. 176-183 Cited: Medicniperspektivi. 2020;25(3):176-183
Ключовi слова: diemmm добавки, анкетування, статистичний анал1з, об'ем продажiв ДД, аптечш заклади, Ma6opamopHi дослiдження, ризик, безпека
Ключевые слова: диетические добавки, анкетирование, статистический анализ, объем продаж ДД, аптечные учреждения, лабораторные исследования, риск, безопасность.
Key words: dietary supplements, questionnaire survey, statistical analysis, volumes of DS sales, pharmaceutical facilities, laboratory research, risks, safety
УДК 613.292:614.3:615.12(477)
О.М. Кузнецова, Н.В. Остатна
