CC BY
2230. Al-Naemi AH, Ahmad AJ. Is the rs1801282 (G/C) Polymorphism of PPAR - Gamma Gene Associated with T2DM in Iraqi People? Open Access Maced J Med Sci. 2018 Mar 14;6(3):447-55. doi: 10.3889/oamjms.2018.156.
31. Botta M, Audano M, Sahebkar A, Sirtori CR, Mitro N, Ruscica M. PPAR Agonists and Metabolic Syndrome: An Established Role? Int J Mol Sci. 2018;19(4):1197. doi: 10.3390/ijms19041197.
32. Yates T, Davies MJ, Henson J, Edwardson C, Webb D, Bodicoat DH, et al. Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes. PLoS ONE.2015;10(5): e0124062. doi:10.1371/journal.pone.0124062.
33. Cartwright T, Mason H, Porter A, Pilkington K. Yoga practice in the UK: a cross-sectional survey of motivation, health benefits and behaviors. BMJ Open [serial on the Internet]. 2020; 10(1): e031848. Available from: https://bmjopen.bmj.com/content/10/1/e031848
34. Chauhan A, Semwal DK, Mishra SP, Semwal RB. Yoga Practice Improves the Body Mass Index and Blood Pressure: A Randomized Controlled Trial. Int J Yoga. 2017;10 (2):103-6. doi: 10.4103/ijoy.IJOY_46_16.
35. Yadav R, Yadav RK, Sarvottam K, Netam R. Framingham Risk Score and Estimated 10-Year
Cardiovascular Disease Risk Reduction by a Short-Term Yoga-Based Life Style Intervention. J Altern Complement Med. 2017; 23(9):730-7.
36. Cramer H. The Efficacy and Safety of Yoga in Managing Hypertension. Exp Clin Endocrinol Diabetes. 2016;124(2): 65-70.
37. Wolff M, Rogers K, Erdal B, Chalmers JP, Sundquist K, Midlov P. Impact of a short home-based yoga programme on blood pressure in patients with hypertension: a randomized controlled trial in primary care. J Hum Hypertens. 2016; 30: 599-605.
38. Liu Y, Lee DC, Li Y, Zhu W, Zhang R, Sui X, et al. Associations of Resistance Exercise with Cardiovascular Disease Morbidity and Mortality. Med Sci Sports Exerc. 2019; 51(3):499-508.
39. MacDonald HV, Johnson BT, Huedo-Medina TB, Livingston J, Forsyth KC, Kraemer WJ, et al. Dynamic Resistance Training as Stand-Alone Antihypertensive Lifestyle Therapy: A Meta-Analysis. J Am Heart Assoc. 2016; 5(10):e003231. doi: 10.1161/JAHA. 116.003231.
40. Schroeder EC, Franke WD, Sharp RL, Lee DC. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial. PLoS One. 2019;14(1):e0210292. doi: 10.1371/journal.pone.0210292.
Tuchkina Iryna
MD, professor, head of the Department of Obstetrics, Gynecology and Pediatric Gynecology, Kharkiv National Medical University, Kharkiv ORCID: https://orcid.org/0000-0003-4280-1474
Pylypenko Natalia PhD student of Department of Obstetrics, Gynecology and Pediatric Gynecology Kharkiv National Medical University, Kharkiv ORCID: https://orcid.org/0000-0002-2417-8765
LEPTIN AND PECULIARITIES OF PUBERTYGENESIS IN ADOLESCENT GIRLS WITH GYNECOLOGICAL PATHOLOGY, BORN LOW OR HIGH TO GESTATIONAL WEIGHT
Тучкина Ирина Алексеевна
д.мед.н., профессор Заведующая кафедрой акушерства, гинекологии и детской гинекологии Харьковский национальный медицинский университет, Харьков, Украина Пилипенко Наталья Сергеевна, аспирант кафедры акушерства, гинекологии и детской гинекологии Харьковский национальный медицинский университет, Харьков, Украина
ЛЕПТИН И ОСОБЕННОСТИ ПУБЕРТАТОГЕНЕЗА У ДЕВУШЕК-ПОДРОСТКОВ С ГИНЕКОЛОГИЧЕСКОЙ ПАТОЛОГИЕЙ, РОДИВШИХСЯ С НИЗКОЙ И ЧРЕЗМЕРНОЙ
МАССОЙ ТЕЛА
DOI: 10.31618/ESSA.2782-1994.2021.2.76.205 Summary. The article outlines the problems of the influence of leptin on the formation of menstrual function in adolescent girls born with low and excessive body weight. The risk factors that are triggers in the formation of
gynecological pathology have been identified and indicated. The deviation of body weight in girls at birth is one of the triggers of the pathological course of pubertygenesis, the course of which is accompanied by a clear relationship between the production of leptin(L) and body mass index(BMI), is manifested by impaired physical development, menstrual function and is most often combined with pathological changes in the functioning of the autonomic nervous system, which must be taken into account when verifying diagnosis and treatment of such patients.
Резюме. В статье изложены проблемы влияния лептина на формирование менструальной функции у девушек-подростков, рожденных с низкой и избыточной массой тела. Выявлены и указаны факторы риска, являющиеся триггерами в формировании гинекологической патологии. Отклонение массы тела у девочек при рождении является одним из пусковых механизмов патологического течения пубертатогенеза, который сопровождается четкой взаимосвязью между продукцией лептина(Л) и индекса массы тела(ИМТ), проявляется нарушением физического развития, менструальной функции и чаще всего сочетается с патологическими изменениями функции вегетативной нервной системы, что необходимо учитывать при верификации диагноза и лечении таких больных.
Keywords. puberty, leptin, small gestational weight, macrosomia
Ключевые слова. пубертат, лептин, малая масса плода, макросомия
Introduction. In recent decades, the demographic situation in Ukraine has been deteriorating. After gaining independence, the influence of negative factors increases, namely the birth rate decreases, the population ages, and the health of Ukrainians deteriorates.
There is instability of economic indicators, and more people are constantly migrating from the country. The combination of such indicators leads to a negative trend, namely in Ukraine now the population is about 10 million less than it was in the early 90's.
At the heart of the priority areas of policy and national security should be the improvement of factors to improve the development of the country's population. Markers of demographic indicators are crucial for improving the state, and the issue of optimizing the development of the population should be a priority, as a priority marker of the outcome of the state.
The size of the national budget is closely correlated with markers of labor potential, which in turn depends on the level of the working population, and at the same time on the factors of demographic indicators.
Data on the examination of current demographic and social factors in Ukraine show that the country is in a deep demographic crisis, which is a consequence of economic and social problems, as well as the growing prevalence of the disease in the regions.
The demographic situation shown is extremely critical and requires the development and implementation of immediate measures to improve it. Such important decisions require a clear reliance on research aimed at optimizing public health issues. Such an algorithm will allow the implementation of strategic planning to overcome the demographic crisis.
Our study was performed within the research area of the Department of Obstetrics, Gynecology and Pediatric Gynecology, Kharkiv National Medical University "Clinical and pathogenetic features and ways to correct pathological conditions of the reproductive system of women at different ages" state registration number 0116U004978.
At the heart of disorders of the reproductive system are changes in the interaction of hereditary, constitutional, metabolic, nutritional factors. The
negative impact of perinatal pathology on the formation of reproductive potential of adolescent girls has been revealed [1, 2, 3]. Questions about the study of the influence of body weight at the birth of girls on the formation of their reproductive health are being seriously studied around the world [4, 5].
Thus, the syndrome of fetal growth retardation remains relevant in the structure of perinatal pathology, has a negative impact on the further development of children, and the birth of overweight children leads to disorders of adaptive processes, abnormalities in somatic, physical and neuropsychological development [6, 7].
Puberty is an extremely important - the milestone of human development, when everything changes in the body, which leads to the formation of sexual and physical maturity [8, 9].
Puberty is the interval between childhood and puberty, streamlines the algorithm of interaction of neuroendocrine factors that shape physical and mental changes, and lead to the formation of physical, mental and reproductive maturity [10].
The final formation of the reproductive system and its potential, as well as the metabolic status of the adult population depend on how fully the adolescent proceeds and how successfully puberty ends[11].
The timing of puberty depends on many genetic factors and external conditions: race and ethnicity, environmental characteristics, geographical location and even the nature of nutrition. Puberty can be defined as a set of successive biological events that are realized by the progression of sexual characteristics, or characteristics that have the ultimate goal of forming a full-fledged reproductive function. It is known that a key role in the initiation of puberty in mammals belongs to the regulatory function of the hypothalamic-pituitary-gonadal axis [12].
Long-term trends indicate a significant reduction in the age of onset of puberty to a greater extent in girls, to a lesser extent - in boys. In recent decades, there has been a higher rate of decline in telarche age compared to menarche in girls. The urgency of the research topic is due to the high and increasing in recent decades the frequency of births of children with deviations of physical development from population standards,
which may play an important role in shaping the physical and sexual development of girls, causing their future reproductive potential. It is well known that one of the important indicators in assessing body weight is a hormone produced by adipose tissue - leptin (L). Adipose tissue is not only a participant in metabolism, but also an endocrine organ, it is integrally involved in the coordination of various biological functions, including energy metabolism, neuroendocrine and immune function. Leptin plays an important role in the initiation of puberty [13].
Leptin is secreted by adipocytes into the blood in varying amounts depending on the needs of the body and acts as a hormone that controls the mass of adipose tissue. The physiological role of leptin is to maintain feedback between the CNS and adipose tissue - the main energy depot in the body. Normoleptinemia is a prerequisite for a balanced activity of the reproductive system as a whole. Disorders of the reproductive system, accompanied by changes in hormonal homeostasis, can lead to violations of the rate of sexual development, starting from the prepubertal period. At the same time, studies only of luteinizing hormone, follicle-stimulating hormone, estradiol and progesterone in the early stages of puberty do not always reflect the state of reproductive function in adolescents [14].
Given that the manifest function of puberty -menstrual function(MF), appears in adolescents who have reached a certain body weight (at least 45-47 kg), we can assume that leptin is one of the markers of character assessment pubertygenesis[15].
Aim. To analyze the leptin level indicators in adolescent girls with pubertal disorders, depending on the body weight at birth and the nature of extragenital pathology.
We aim to find prognostic criteria for identifying risk groups to reduce the reproductive potential of young people, namely among adolescent girls born with polar body weight values.
Material and methods. The work was performed on the clinical base of the Department of Obstetrics, Gynecology and Pediatric Gynecology of Kharkiv National Medical University. All patients signed informed consent to participate in the study.
Inclusion criteria: voluntary informed consent of patients and their parents to conduct the study, accurate information on body weight at birth, birth at 37-41 weeks of gestation, the presence of gynecological pathology in the absence of abnormal development of the genitals. Patients born less than 37 weeks or more than 41 weeks of multiple pregnancies were excluded from the study.
69 adolescent girls aged 11-17 with gynecological disorders (dysmenorrhea syndrome, oligo- and opsomenorrhea, amenorrhea, abnormal uterine bleeding) were examined. Of these, 34 patients were born with a body weight less than 2500 g - 1 group, and 35 patients - with a body weight over 4000 g - 2 group.
To verify the diagnosis, a detailed collection of complaints and anamnesis, clinical analysis of menstrual function, ultrasound of the pelvis,
assessment of sexual development, determination of levels of gonadotropic and sex hormones, and L. All girls were assessed for gynecological status through recto - abdominal and vaginal examinations depending on sexual experience.
With the help of line diagrams developed in the IODP of the Academy of Medical Sciences of Ukraine, the nature of physical development of adolescent girls was determined[16].
Body mass index (BMI) was measured, which is closely correlated with the total body fat content: BMI = weight, kg / height, m2 According to the WHO classification, BMI less than 18.5 kg / m2 corresponds to insufficient, 18.5 - 24.9 kg / m2 - normal, greater than or equal to 25.0 - overweight, more than 30.0 kg / m2 -obesity.
Sexual development was studied on the basis of the sequence of occurrence and severity of secondary sexual characteristics. The degree of sexual development of girls was assessed by the formula Ma + P + Ax + Me, which includes the following indicators: development of the mammary glands - Ma, pubic hair -P, axillary hair - Ah and mf[17].
Comprehensive clinical and laboratory research was supplemented by consultation with a neurologist with examination of the function of the central and autonomic nervous system.
Discussion. It was found that MF disorders were observed with the same frequency in both groups of patients and their nature did not differ significantly. At patients of 1 group disturbances on type of a syndrome of a dysmenorrhea and abnormal uterine bleedings proceeded more often against deficit, at patients of 2 groups - against excess of body weight.
In the majority of respondents (54 - 78.3%) disorders of the autonomic nervous system were detected: astheno-neurotic syndrome, autonomic dysfunction. Leptin levels were elevated in obese patients and decreased in girls with impaired physical development by type of weight loss and closely correlated with BMI.
Conclusions. Deviation of body weight in girls at birth is one of the triggers of the pathological course of puberty, during which there is a clear relationship between the production of L and BMI, manifested by impaired physical development, menstrual function and often combined with pathological changes in the autonomic nervous system should be taken into account when verifying the diagnosis and treatment of such patients.
The obtained results make it possible to differentiate markers of reduction of ovarian reserve of adolescent girls. This allows for optimization in the formation of risk groups. With the new results of the onset of puberty, we are able to predict and monitor changes in reproductive capacity, as well as implement preventive measures to improve the female health of adolescent girls.
References:
1. Wennerstrom EC, Simonsen J, Melbye M. Long-Term Survival of Individuals Born Small and
Large for Gestational Age. PLoS One. 2015 Sep 21;10(9):e0138594. doi:
10.1371/journal.pone.0138594. PMID: 26390219; PMCID: PMC4577072.
2. Vikström J, Hammar M, Josefsson A, Bladh M, Sydsjö G. Birth characteristics in a clinical sample of women seeking infertility treatment: a case-control study. BMJ Open. 2014 Mar 10;4(3):e004197. doi: 10.1136/bmjopen-2013-004197. PMID: 24613821; PMCID: PMC3963097.
3. Garces A, Perez W, Harrison MS, Hwang KS, Nolen TL, Goldenberg RL, Patel AB, Hibberd PL, Lokangaka A, Tshefu A, Saleem S, Goudar SS, Derman RJ, Patterson J, Koso-Thomas M, McClure EM, Krebs NF, Hambidge KM. Association of parity with birthweight and neonatal death in five sites: The Global Network's Maternal Newborn Health Registry study. Reprod Health. 2020 Dec 17;17(Suppl 3):182. doi: 10.1186/s12978-020-01025-3. PMID: 33334362; PMCID: PMC7745358.
4. Ma R, Luo Y, Wang J, Zhou Y, Sun H, Ren X, Xu Q, Zhang L, Zou L. Ten-year time trends in preterm birth during a sociodemographic transition period: a retrospective cohort study in Shenzhen, China. BMJ Open. 2020 Oct 20;10(10):e037266. doi: 10.1136/bmjopen-2020-037266. PMID: 33082182; PMCID: PMC7577040.
5. Huraseva A.B. Reproduktivnoe zdorovje zhenshin, rodivshihsya s polyarnymi znacheniyami masy tela: Avtoreferat. dis. d-ra med. nauk: cpec. 14.01.01« Akusherstvo i ginekologiya» / Huraseva A.B. - Volgograd, 2010. - 10 s.
6. Nazarenko L.G., Nesterzova N.S. Aspekty reproduktivnogo zdorovja u zhenshin s niskoy i izbytochnoy massoy tela pri rozhdenii. Zdorovje zhenshiny. 2016; № 10: 53-55.
7. Bogdanova EA. Prakticheskaya ginekologiya molodykh [Practical gynecology of young people]. Moscow: "Medical book"; 2011. P. 238
8. Rannee i pozdnee poyavlenie pervoy menstruatsii (menarhe) u devochek [Elektronnyiy resurs] // Derzhavna ustanova «Institut ohoroni zdorov'ya dItey ta pIdlltklv NatsionalnoYi akademIYi medichnih nauk UkraYini». - Rezhim dostupu: http: //iozdp. org.ua/ index.php/2012-09-03-08-35-35
9. Tuchkina M. Yu. Treatment of adolescent girls with abnormal uterine bleeding taking into account psychoemotional and vegetative status / Tuchkina I. A., Tuchkina M. Yu., Novikova A. A. // Journal of Education, Health and Sport. 2019;
9(5):575-582.eISNN 2391-8306. DOI
http://dx.doi.org/10.5281/zenodo.3239459
10. Tuchkina I. Disorders of menstrual function in adolescents with autonomic dysfunction / Tuchkina I., Tuchkina M., Merenkova I., Gnatenko O., Dobrovolskaya L. // Abstract book of the 19- th World Congress of PAG, 2020, P-105, p.34
11. Korrektsiya narusheniy vegetativnoy nervnoy sistemyi u podrostkov s ginekologicheskoy patologiey/ M.Yu.Tuchkina// Materiali Vseukrayinska naukovo-praktichna konferentsiya «Aktualni pitannya akusherstva, ginekologiyi I reproduktivnoyi meditsini» 20 zhovtnya 2017 roku, m. Zaporizhzhya, st. 24 - 25
12. Tuchkina I.A., Dobrovolskaya L.A., Tuchkina M.Yu. Kliniko-diagnosticheskie aspektyi pervichnoy dismenorei v podroskovom vozraste // Medicine (Almaty). - 2016. - No 6 (168). - R. 51-56.
13. I. Tuchkina, L. Vygovskaya, A. Novikova. Features of uterine blood flow in adolescents with abnormal uterine bleeding of puberty. J Clin Med Kaz. 2019; 4(54):21-24
14. Tuchkina I.O., L.A. Dobrovolska, L.A.VigIvska, M.Yu TuchkIna / SposIb lIkuvannya dismenoreYi u dIvchat-pIdlItkIv // Patent na korisnu model #94513U opubl.10.11.2015, dIE z 10.11.2015 ,UkraYina. Z. № u201408487 vId 25.07.2014. Zayavnik ta patentovlasnik HNMU.
15. Zatrimka rostu vnutrishnoutrobnogo ploda : metodichnI vkazIvki dlya likariv-interniv, likarIv akusheriv-ginekologiv, dityachih ginekologiv, pediatriv, simeynih likariv / uporyadniki : I. O. Tuchkina, L. A. Vygovska, G. V. Maltsev [ta in.]. -Kharkiv : HNMU, 2018. - 40 s.
16. Danilenko G.N., Shvets A.N., Shvets Yu.N. Fizicheskoe razvitie harkovskih podrostkov v dinamike za 30 let // SMB. 2017. №1 (59). URL: https://cyberleninka.ru/article/n/fizicheskoe-razvitie-harkovskih-podrostkov-v-dinamike-za-30-let (data obrascheniya: 11.01.2022)
17. Bogdanova, E. A. Morfofunktsionalnaya i somatotipologicheskaya harakteristika shkolnikov Respubliki Kalmyikiya: avtoref. dis. ... kand. biol. nauk. / E.A Bogdanova. - Astrahan, 2010. - 26 s.
Corresponding author
ORCID ID https://orcid.org/0000-0002-2417-
8765
Natalia Serhiivna Pylypenko,
Kharkiv National Medical University, Nauki Avenu 4, Kharkiv, Ukraine. +380958105662,
