Laser-ablative synthesis of novel functional nanoformulations for biomedical applications Текст научной статьи по специальности «Нанотехнологии»

LP-I-4

Laser-ablative synthesis of novel functional nanoformulations for biomedical applications

A. Kabashin12

1Aix-Marseille Univ. - CNRS, LP3, Marseille, France

2MEPHI' Institute of Engineering Physics for Biomedicine PhysBio, Moscow, Russian Federation

The presentation will overview our on-going activities on laser ablative synthesis of novel biocompatible colloidal nanomaterials and their testing in biomedical tasks. Our original approach is based on ultra-short (fs) laser ablation from a solid target or already formed water-suspended colloids to fabricate "bare" (ligand-free) nanoparticles (NPs) with well-controlled size characteristics [1-3], as well as coating of nanomaterials by functional molecules (dextran, PEG etc.) during the ablation process [4] or afterwards [5]. The presentation will describe different approaches to achieve appropriate characteristics of plasmonic (Au, TiN) and semiconductor (Si-based structures) nanomaterials and overview their biomedical applications. In particular, we show that bare laser-synthesized Au NPs can provide unique opportunities as SERS probes for identification of biological species such as yeast [6] and bacteria (Listeria innocua and Escherichia coli) [7] based on strong local electric field enhancement and exceptional purity of laser-synthesized NPs. We also show that bare metal nanoparticles synthesized by laser ablation can provide an order of magnitude better response in glucose oxidation tasks, which promises their use as elecrocatalysts in bioimplantable therapeutic devices [8], as well as overview applications of plasmonic nanomaterials (TiN) in phototherapy tasks [9]. We finally overview applications of Si NPs, which exhibit a unique combination of biocompatibility and biodegradability options. In particular, we show that laser-synthesized NPs can be used as efficient markers in tasks of linear [10] and non-linear [11] optical bioimaging. In addition, these nanoparticles can be used in mild cancer therapies, e.g. as sensitizers of radiofrequency radiation-based hyperthermia [12] and as carriers of therapeutic 188Re radionuclide in nuclear nanomedicine tasks [5].

References

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[2] K. Maximova, A. I. Aristov, M. Sentis, and A. V. Kabashin, Nanotechnology, Vol. 26, pp. 065601 (2015).

[3] T. Baati, A. Al-Kattan, M.-A. Estève, L. Njim, Y. Ryabchikov, F. Chaspoul, M. Hammami, M. Sentis, A. V. Kabashin, D. Braguer, Sci. Rep., Vol. 6, pp. 25400 (2016).

[4] F. Correard, K. Maximova, M.-A. Estève, C. Villard, A. Al-Kattan, M. Sentis, M. Roy, M. Gingras, A. V. Kabashin and D. Braguer, Int. J. Nanomedicine, Vol. 9, pp. 5415 (2014).

[5] V. M. Petriev et al., Sci. Rep., Vol. 9, pp. 2017 (2019).

[6] S. Uusitalo et al, J. Food Eng., Vol. 212, pp. 47 (2017).

[7] M. Kögler et al, J. Biophotonics, Vol. 11, pp. e201700225 (2018).

[8] S. Hebie et al, ACS Catal., Vol. 5, pp. 6489 (2015).

[9] A. A. Popov et al, Sci. Rep., Vol. 9, pp. 1194 (2019).

[10] M. B. Gongalsky et al., Sci. Rep., Vol. 6, pp. 24732 (2016).

[11] A. Kharin et al, Adv. Opt. Mater., Vol. 7, pp. 1801728 (2019).

[12] K. P. Tamarov et al, Sci. Rep., 4, 7034 (2014).