46. 3 minutes after exposure to
with glycerin glycerol
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ISI: 0,967 | Cite-Factor: 0,89 | SIS: 1,9 | ASI: 1,3 | SJIF: 5,771 | UIF: 6,1
pic. 7. 5 minutes after exposure to pic. 8. 10 minutes after exposure to glycerol. glycerol
At the third minute of exposure, a change in the shape of the scolex was determined in the direction of stretching and swelling of the cell membrane (Pic. 6). At the 5th minute of exposure, the destruction of the germinal membrane was observed with a thickening of the cellular structure and with partial staining in brown color (Pic. 7,8). Summing up the results of cytological studies in group 2 patients, it can be assumed that 80% glycerin in its scolexicidal action is an effective disinfectant of the residual cavity of the fibrous capsule and is not inferior to 0.02% furatsilin solution and 30% hypertonic solution, which was the reason for us to use 80% glycerin solution in the clinic.
Along with the observance of the principles of aparasitism and antiparasitism during the operation, patients in the postoperative period underwent stimulation of specific immunity and chemotherapy with albendazole. In addition, detoxification, antioxidant and hepatoprotective therapy was performed in the postoperative period. It is well known that Echinococcus stimulating the immune on the one hand, on the other hand, causes suppression of the immune response and suppresses the host's defense mechanisms both against their own antigens (homologous immunosuppression) and antigens of other agents infecting organisms. It was found that most of the studied patients with ED are characterized by the presence of an immunodeficiency state of varying severity; the most pronounced immunodeficiency state is observed in patients with a long history of the disease, a severe course of the pathological process, and pronounced changes in biochemical tests. For the purpose of immunostimulation and preventive prophylactic treatment of immunodeficiency, immunomodulin was used in the complex of treatment for patients in the preoperative and postoperative period. Immunomodulin was used at a dose of 2.0 ml intramuscularly 2 times a day. One of
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ISSN: 2181-1385 ISI: 0,967 | Cite-Factor: 0,89 | SIS: 1,9 | ASI: 1,3 | SJIF: 5,771 | UIF: 6,1
the effective methods of preventing postoperative complications and recurrence of the disease in operated patients was preventive antibiotic therapy with albendazole. The drug "Albendazole" was taken in two doses at a standard dosage of 10-12 mg/kg. Chemotherapy was also combined with the use of furazolidone 50 mg 3 times a day, metronidazole 250 mg 2 times a day. As hepatoprotectors, we used the drug Essentiale forte according to
300 mg intravenously, Hepa-Merz 10 mg per 400 ml infusion solution. Thus, the purpose of prophylactic chemotherapy was to rehabilitate the body of a patient with echinococcosis with an anthelmintic chemotherapy drug in order to prevent the recurrence of the disease in the postoperative period.
CONCLUSION
Thus, the choice of treatment and diagnostic tactics for liver echinococcosis in most cases depends on the nature of the lesion, the number and size of echinococcal cysts, as well as on the choice of the most optimal access and methods for isolating the surgical field, antiparasitic treatment of the cyst and rational drainage of residual cavities, based on the principles aparasiticity and antiparasiticity of echinococcectomy, increase the radicalness of operations and sharply reduce the likelihood of recurrence of the disease. Conducted immune-stimulation improves the course of the early postoperative period. Pre- and postoperative chemotherapy with albendazole in combination with an immunostimulant immunomodulin and hepatoprotectors, as well as consistent, phased and effective treatment of echinococcal cysts, reduced the incidence of immediate complications by 2-3 times.
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