CC BY
122
Table 1: List of some plants used as anthelmintic in folk medicine in Turkey
Botanical name Family Local name Plant part used Preparation, administration and use Reference
Artemisia absinthium L. Asteraceae Aci yavçan, Pelin otu Aerial part Inf., Int. [4]
Artemisia santonicum L. Asteraceae Aci yavçan, Yavçan, Kekik Flower Inf., Int. [4]
Centaurium erythraea Rafn. subsp. erythreae Gentianaceae Afyon otu, Kirmizi kantaron Aerial part Mac., Int. [5]
Chenopodium botrys L. Chenopodiaceae Kuç otu Aerial part Inf., Int. [6]
Chondrilla juncea L. var. acantholepis (Boiss.) Boiss. Asteraceae Sakiz otu Aerial part Dec., Int. [6]
Crataegus meyeri Pojark. Rosaceae Aliç, Aluç, Rihok Fruit Dec., Int. [6]
Crataegus monogyna Jacq. subsp. mo-nogyna Rosaceae Aliç, Aluç, Güjok Fruit Dec., Int. [6]
Hypericum perforatum L. Hypericaceae Sari kantaron, Su kantaronu Aerial part Inf., Int. [4]
Juniperus drupacea Lab. Cupressaceae Andiz agaci Fruit Molasses, Int. [8]
Papaverpseudo-orientale (Fedde) Medw. Papaveraceae Gelincik, Yabani haçhaç Aerial part Inf., Int. [6]
Peganum harmala L. Zygophyllaceae Üzerlik Seed, Root Inf., Int. [4]
Prunus armeniaca L. Rosaceae Kayisi Seed [7]
Thymus fallax Fisch. Mey. Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [9]
Thymus kotschyanus Boiss. et Hohen. Subsp. glabrescens Boiss. Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [9]
Thymus kotschyanus Boiss. et Hohen. var. kotschyanus Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [6]
Thymus migricus Klokov&Des.- Shost. Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [9]
Thymus praecox Opiz.subsp. grossheimii (Ronniger) Jalas var. grossheimii Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [9]
Thymus transcaucasicus Ronniger Lamiaceae Kekik, Kekotu, Keklik otu Aerial part Inf., Int. [9]
Int: Internal, Dec: Decoction, Inf: Infusion, Mac: Maceration
References:
1. Demirci S, Özhatay N, 2012. Turkish Journal of Pharmaceutical Sciences, 9 (1):75-92.
2. Gürdal B, Kültür S, 2013. J of Ethnopharmacology. 146:113-126.
3. Bahmani M, Rafieian-Kopae Mi, Hassanzadazar H, Saki H, Karamati SA, Delfan B, 2014. Asian Pacific Journal of Tropical Medicine, 7(1):29-33.
4. Oral DC. 2007. Thesis. Ankara: Gazi University, Programme of Phytotherapy.
5. Kizilarslan C, Özhatay N, 2012. Turkish Journal of
Pharmaceutical Sciences, 9(2):199-218.
6. Dogan A, Tuzlaci E, 2015. Marmara Pharmaceutical Journal, 19:126-135, 2015.
7. Gengay A. 2007. Thesis. Van: Yüzüncü Yil University, Department of Biology.
8. E§en B. 2008. Thesis. Konya: Selguk University, Department of Biology.
9. Altundag E. 2009. Thesis. istanbul: istanbul University, Department of Pharmaceutical Botany.
FUNCTIONAL DYSPEPSIA IN THE ELDERLY: META-ANALYSIS OF ACTIVE RANDOMIZED CONTROLLED TRIALS WITH A HERBAL MEDICINAL PRODUCT, STW 5
© Müller Jürgen1, Fink Careen1, Rabini Sabine1, Kelber Olaf2, Nieber Karen3, Kraft Karin4, Storr Martin A.5
1 Medical and Clinical Affairs Phytomedicines, Innovation and Development, Phytomedicines Supply and Development Center, Bayer Consumer Health Division, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany;
2 Innovation and Development, Phytomedicines Supply and Development Center, Bayer Consumer Health Division, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany, Darmstadt;
3 Pharmaceutical Institute, Leipzig University, Leipzig, Germany;
4 Chair for Naturopathy, Center for Internal Medicine, University Medicine Rostock, Rostock, Germany;
5 Center for Endoscopy, Starnberg, Germany
In an ageing population, natural treatment options for For answering the question, whether the efficacy functional digestive diseases gain increased attention. in such a treatment option, STW 5, is comparable in
Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] vol. 15/2017/suppLement 1
1 29
patients of different age groups, respective sub-group analyses of the available randomized controlled clinical trials were conducted.
After meta-analyses of the randomized controlled double blind trials had shown compliance to modern standards for a proof of efficacy, in a second step, subgroup analyses were conducted.
The as well as the therapeutic dose (3 x 20 drops/day) were identical in all trials so allowing a uniform evaluation. For the primary outcome variable, the validated gastrointestinal symptom score (GIS) [1] the difference
between placebo and verum after 28 days of treatment showed a highly significant (p < 0.0001) difference between placebo and verum (6.7 resp. 4.7 points). The analyses in different age groups did show a comparable efficacy also in elderly patients.
The meta-analysis clearly shows the efficacy and tolerability of STW 5 (Iberogast) also in elderly patients.
References:
1. Adam et al. 2005. Aliment Pharmacol Ther. 22:357363.
ALTHEA OFFICINALIS L. IN DRY COUGH ASSOCIATED WITH PHARYNGEAL IRRITATION
© Fink Careen2, Müller Jürgen2, Kelber Olaf1, Nieber Karen3, Kraft Karin4
11nnovation and Development, Phytomedicines Supply and Development Center, Bayer Consumer Health Division, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany;
2 Medical and Clinical Affairs Phytomedicines, Innovation and Development, Phytomedicines Supply and Development Center, Bayer Consumer Health Division, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany;
3 Pharmaceutical Institute, Leipzig University, Leipzig, Germany;
4 Chair for Naturopathy, Center for Internal Medicine, University Medicine Rostock, Rostock, Germany
With herbal preparations from Althaea officinalis L., radix (marshmallow root), there exists long-standing experience of use as a demulcent preparation for the symptomatic treatment of oral or pharyngeal irritation and associated dry cough, which has also led to the issuing of a monograph of the European regulatory authority EMA [1].
Creating a better documentation of the users' impression of the effectiveness and tolerability and of their satisfaction was the aim of the two prospective, non-interventional surveys reported here.
Altogether 822 users of an aqueous Marshmallow root extract, STW 42, were recruited in pharmacies, in two separate studies, one for lozenges, the other for syrup. They were asked to fill in a questionnaire covering a treatment duration of seven days for the
documentation of the course of symptoms of their dry cough, and the global assessments of effectiveness, tolerability and satisfaction.
The users stated that both preparations showed a good effect with respect to the symptomatic treatment of oral or pharyngeal irritation and associated dry cough with a very rapid onset of effects, in the majority of cases within 10 minutes. The tolerability was very good (3 minor adverse events for the syrup).
The use of Marshmallow root syrup and lozenges for symptomatic treatment of dry cough is strongly supported by these studies.
References:
1. European Union herbal monograph on Althaea officinalis L., radix, EMA/HMPC/436679/2015
ANTI-INFLAMMATORY AND CYTOPROTECTIVE EFFECTS OF A HYPERICUM PERFORATUM EXTRACT, STW 3-VI
© Schwendler A.1, Abdel-Aziz Heba2, Keiber Olaf3, Hüther Julian1, Bonaterra Gabriel A.1, Cordes Andrea1, Kolb Christiane2, Kinscherf Ralf1
1 Philipps-University Marburg, Department of Medical Cell Biology, Marburg, Germany;
2 Bayer Consumer Health, Medicial Affairs, Phytomedicines Supply and Development Center, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany;
3 Bayer Consumer Health, Innovation & Development, Phytomedicines Supply and Development Center, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany
Glutamate toxicity and inflammation are involved in the antidepressant effects [2] by normalization of an
a variety of disorders, e. g. those involving adaptation to overactive hypothalamic-pituitary-adrenal axis [3].
chronic stress. In this context, the combined antioxidant Thus, the aim of our investigations was to determine
and anti-inflammatory properties [1] of St. John's wort the effects of a St. Johns wort extract, STW 3-VI,
(Hypericum perforatum L.) extract could contribute to on protection of differentiated mouse hippocampal
Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy]
vol. 15/2017/suppLeMEnT 1
