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Experience of the optimum exposition of enterosgel establishment for treatment of the periodontal disease at patients.
It was found that family history of substance dependence and mental disorders may contribute to alcohol abuse and deviation of the patient.
Conclusion. Thus, the above results of the comparative analysis of the clinical features of alcohol dependence demon-
strates that patients with behavioral problems have earlier and rapid development of alcohol dependence, as well as the more malignant it over, accompanied by a variety of complications and were more frequent and faster breakdowns of therapeutic remission.
References:
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Daminova Nargiza Ravshanovna, Tashkent State Dental Institute, Dentist at the clinic of Tashkent State Dental Institute E-mail: ndaminova82@gmail.com
Kamilov Khaydar Pozilovich, Tashkent State Dental Institute, Head of Department of Hospital Therapeutic Dentistry, Professor, PhD E-mail: Khaydar.Kamilov@mail.ru
Sadikov Abdushukur Abdujamilevich, Rector of Andijan Medical Academy, PhD E-mail: abdushukur.sadikov@minzdrav.uz
Experience of the optimum exposition of enterosgel establishment for treatment of the periodontal disease at patients with vesicular disease
Abstract: Based on clinical studies it was found that the optimum mode enterosgelya exposure to the area affected by periodontal pockets is 2 hours. During this period it was observed decrease in the total microbial contamination gingival fluid in more than 25,000 times; restores the balance of gram-negative and gram-positive microorganisms.
Keywords: Enterosgel, periodontal disease, vesicular disease, gram-negative and gram-positive microorganisms.
From the clinical point of view vesicular disease belongs to difficult multifactorial diseases and is bound to development and persistence of processes of endogenic intoxication which is shown by essential augmentation in a blood of molecules of average weight and activation of proteolytic processes [4, 22-25; 6, 28].
It is known that emergence and advance of a periodontal disease is caused by activation of constantly present microorganisms, development of clinically defined inflammatory reaction which appointment consists in neutralizing the toxins and enzymes blasting tissues is a consequence of that, and also to destroy and microbial cells.
At synchronization of an inflammation in tissues in a large number the substances which are initially protecting, and as a result actively striking these tissues accumulate. Accumulation of the toxins formed by infectious agents aggravates metabolic disorders, leads to development of various pathological states. As a result in liquid of the parodontal pockets (PP) and other biological
liquids (stomatic liquid, a blood) products of a destruction of tissues collect, causing intoxication syndrome. Among bonds of this sort the important role belongs to middlemolecular peptides (MP) [2, 52-54; 5, 22].
In complex treatment of generalized periodontitis (GP) as an agent of detoxication therapy the sorbent of "Enterosgel" is widely applied. Enterosgel — a silicon organic compound — is made by JSC Silma (Russia). It is used inside, in a dose of 15 g. 2-3 times a day between meals, washing down with a glass of water. It is shown that reception of enterosgel in the specified dosage leads to depression at sick with GP of symptoms and indicators of endogenic intoxication [3, 22-25].
It is obvious that local application of sorbents for treatment of diseases of a parodont especially significantly at patients with vasicular disease at whom endogenic intoxication is one of the main pathogenetic mechanisms of development of a basic disease.
Section 4. Medical science
In this regard establishment of an optimum exposition of enterosgel local application for treatment of a parodontal disease at patients with vasicular disease is actual.
All above defined is considered as the purpose of researches: development of an optimum regimen of local use of enterosgel for treatment of a parodont.
Materials and methods
Obj ect of studying were 30 people with the verified diagnosis ofan exacerbation ofan akantolic vesicular disease and a periodontal disease. The group ofcomparison was made by10 people ofa comparable floor and age who don't have dermal pathology and clinical implications of an inflammatory and destructive lesion of a parodont.
Prior to treatment all patients were trained in rules of hygiene of an oral cavity, refusal of smoking is recommended. Mechanical therapy was carried out: excision of plaques, curettage of parodontal pockets (PP); elimination of the factors leading to microtraumatizing of a parodont. Then under a protective retentive bandage on area of the struck pockets enterosgel was imposed. Various methods of a local exposition of enterosgel are studied. Depending on an exposition regimen all patients are divided into 3 groups: 1st group (10 people) the preparation for 1 hour was imposed; 2nd group (10 people) — on 2 hours and the 3rd group (10 people) imposed a preparation for 3 hours. A basis oflocal therapy is elimination of the etiological factor associated with tooth plaques, promoting the striking effect on a tissue.
In this regard before applying of enterosgel the total of microorganisms in the separated PP (Total bacterial count — TBC in 1 ml.), and also balance of gram — negative and gram — positive microorganisms in smears from the separated PP was studied by the standard methods in microbiological researches.
As markers of endogenic intoxication concentration of Middle Molecules (MM) 260 and MM 280 was estimated by a spectrometer method [1, 138-140]. The quantity of MM was calculated on Kalkar's method [2, 52-54].
Crevicular fluids for researches were received via using methods applied by Zakharova N. and Ivanova I. [9, 1-3].
Results of statistical researches processed through computer programs as "Microsoft Excel" and "Statistics". Correlation between parameters was defined by coefficient of correlation of Student. Differences were considered reliable at P < 0.05.
Results and discussion
The analysis of the obtained data revealed increasing of the maintenance of microorganisms in the separated PP at all examined patients. The total of microorganisms exceeded indicators of conditionally healthy faces on 3 and more orders (> 1000 times). In bacterial structure of the separated PP at sick with GP the imbalance of gram-negative and gram-positive forms with prevalence ofgram-neg-ative rods which specific gravity in the compared groups fluctuated Table 1. - Dynamics of the bacterial structure
within 60.8-63.6 %. Microbiological researches showed value of gram-negative microflora in a lesion of a parodont. Our researches will be compounded with data of other authors who proved value of gram-negative microflora in development ofpathology ofa parodont. In the PP a huge variety of microorganisms accumulates, thus the leading role is assigned to the gram-negative bacteria pathogens starting processes of a destructive lesion [7, 213-238; 8, 498-510].
Appreciable depression ofthe general microbial content of the PP at all studied exposition regimens is established. So, at an exposition within 1 hour of TBC decreases by 15 830 times; within
2 hours — by 25 700 times and during 3 hours — by 25 400 times.
It is necessary to notice that after Enterosgel's exposition the ratio of the studied forms of microorganisms that consisted in depression of specific gravity of gram-negative forms significantly changed positively. Thus, after an exposition within 1 hour specific gravity of gram-negative rods decreased by 1.76 times; gram — negative coccuses — by 1.57 times; and specific gravity of gram — positive forms on the contrary grew in 3.16 and 4.03 times, respectively.
Maximum efficiency of restoration of balance of bacterial flora is installed in the separated PP when using an exposition 2 and
3 hours. So, specific gravity of gram — negative rods went down in 3.32 and 3.23 times respectively at 2 and 3rd hour of exposition; the corresponding depressions for gram — negative coccuses made — by 1.75 times and 1.91 times; and augmentation of gram — positive rods and coccuses — in 4.58-4.70 and 3.44-3.75 times, respectively.
In groups of comparison to an exposition of enterosgel essential augmentation ofMM 260 and MM280 is registered (by 2.64-2.13 times). Local application of enterosgel within 1 hour led to depression of MM 260 for 21.43 % (P < 0.01) and MM280 — for 22.39 % (P < 0.01). Results of expositions within 2-3 hours didn't tap essential differences in MM sorption; depression of concentration of MM 260 made 46.55-47.37 %; MM 280 — 48.48-48.53 %, respectively.
The syndrome of endogenic intoxication accompanies many diseases and pathological states, defining their severity of progression and the forecast [5, 22]. It is obvious that depression of markers of endogenic intoxication in a periodontal can render an essential contribution in cupping of local inflammatory and destructive process gives the chance of rational correction of the taped disturbances by preparations of sorption action.
Including of local sorption therapy in complex treatment of a periodontal disease promotes essential decrease of a microbial content of the parodontal pockets, restores balance of gram-negative and the gram-positive microorganisms, significantly reduces the level of endogenic intoxication.
Taking into account efficiency of restoration of PP microbial associations and fall of indicators of endogenic intoxication the exposition of enterosgel for a period of 2 hours is optimum. a microflora of separated parodontal pockets
of
Group Term of exposition Research period TBC in m. k./1 ml Balance of gram-negative and gram-positive forms, %
rods coccus
Negative positive negative positive
Conditionally healthy, n = 20 - - 1.2-10 3 ± 0.05-10 3 8.0 40.5 9.0 42.5
1st group, n = 10 1 hour Before treatment 8.31-10 8 ± 0.35-10 3 63.6 7.4 22.8 6.2
After treatment 5.25-10 4 ± 0.21-10 4 ° 36.2 24.3 14.5 25.0
2nd group, n = 10 2 hours Before treatment 8.25-10 8 ± 0.37-10 4 60.8 8.0 21.7 9.5
After treatment 3.21-10 3 ± 0.11-10 3 * 18.3 36.6 12.4 32.7
3rd group, n = 10 3 hours Before treatment 8.33-10 8 ± 0.31-10 8 61.4 7.7 22.0 8.9
After treatment 3.28-10 3 ± 0.06-10 3 * 19.0 36.2 11.5 33.3
Note: ° — P < 0,05 in relation to size before treatment; * — P < 0.05 in relation to the 1stgroup.
Value of lymphocytes antigen-binding indicators to the cellular antigen of the different organs in patients with congenital...
Table 2. - Dynamics of middle molecular peptides in separated parodontal pockets (g/l)
Group Term of exposition Research period MM260 MM280
Healthy, n = 20 - - 0.22 ± 0.01 0.32 ± 0.01
1st group, 1 hour Before treatment 0.56 ± 0.02 0.67 ± 0.01
n = 10 After treatment 0.44 ± 0.01* 0.52 ± 0.02*
2nd group, 2 hours Before treatment 0.58 ± 0.02 0.66 ± 0.03
n = 10 After treatment 0.31 ± 0.01* 0.34 ± 0.01*
3 rd group, 3 hours Before treatment 0.57 ± .02 0.68 ± 0.03
n = 10 After treatment 0.30 ± 0.01* 0.35 ± 0.01*
Note: * — P < 0.05 in relation to size before treatment.
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3. Maksimovskiy Y. M., Sargsyan M. A., Voloshin E. V. Influence of detoxification therapy using enterosgelya the duration of remission of chronic generalized periodontitis in appointing him to the immunomodulator "Imudon"//Dentistry for all. - 2004. - № 4. - P. 22-25.
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9. Zakharova N. B., Ivanova I. A. Profile of cytokines in gingival fluid in periodontal diseases. Standardization of pre-analytical phase of research//Vector-Best News. - 2009. - № 4(54). - P. 1-3.
Ibadov Ravshan Alievich, Head of Department of Intensive Care in the Republican Specialized Center of Surgery of the name Acad. V. Vahidov, Doctor of Medical Sciences
E-mail: tmsravshan@mail.ru.
Ahmedova Khalida Yuldashevna, Deputy Director in the Scientific Research Institute of Epidemiology Microbiology
and Infectious Diseases, Doctor of Medical Sciences E-mail: Akhmedova1957@mail.ru Abralov Hakimjan Kabuljanovich, Head of the Department of Surgery of congenital heart defects in the Republican Specialized Center of Surgery of the name Acad. V. Vahidov, doctor of Medical Sciences
E-mail: hakim1970@yandex.ru Alimdjanova Nelya Yunusovna, doctor-intern of resuscitation and intensive care in the Republican Specialized Center of Surgery of the name Acad. V. Vahidov
E-mail: sk.riko999@mail.ru
Value of lymphocytes antigen-binding indicators to the cellular antigen
of the different organs in patients with congenital heart failure, complicated pulmonary hypertension on stages of the surgical treatment
Abstract: On 52 patients between the ages of 3 to 14 with congenital heart failure, complicated pulmonary hypertension on 3rd degree are learned dynamic of Antigen binding lymphocytes (ABL), specific to sensibility to the Tissue Antigen (TA) of brain, heart, lungs, and kidneys depend on different methods of insertion. By adding to traditional treatment of iPDE-5 showed noticeable decrease of the ABL to TA of the lungs, endocardium, and myocardium in patients the
