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EVALUATION OF LIPID SPECTRUM AND FATTY ACID CHANGES IN PATIENTS WITH PAINLESS MYOCARDIAL ISCHEMIA Niyazova Ya.M.1, Abduvalieva G.T.2, Soliev A.K.3
1Niyazova Yarkina Mirzakhamdamovna - Assistant;
2Abduvalieva Gavkhar Tulkinovna - Assistan; 3Soliev Alisher Kadirovich - Candidate of Medical Sciences, Assistant, DEPARTMENT OF GENERAL PRACTITIONERS № 1, ANDIJAN STATE MEDICAL INSTITUTE, ANDIJAN, REPUBLIC OF UZBEKISTAN
Abstract: this scientific article mainly studied the lipid spectrum and fatty acid metabolism in patients diagnosed with painless ischemia of the myocardium. A total of 37 patients were examined and divided into 2 groups. Group I -control group (healthy, group II - patients with painless myocardial ischemia. The results showed significant changes in the lipid profile and an increase in fatty acids in patients with painless myocardial ischemia. Painless ischemia of the myocardium was characterized by acute disturbances of lipid metabolism in patients diagnosed with: U, elevated AI and decreased. Keywords: atherosclerosis, lipid spectrum, fatty acids.
ОЦЕНКА ИЗМЕНЕНИЙ ЛИПИДНОГО СПЕКТРА И ЖИРНЫХ КИСЛОТ У БОЛЬНЫХ БЕЗБОЛЕЗНЕННОЙ ИШЕМИЕЙ МИОКАРДА Ниязова Я.М.1, Абдувалиева Г.Т.2, Солиев А.К.3
1Ниязова Яркина Мирзахамдамовна - ассистент;
2Абдувалиева Гавхар Тулкиновна - ассистент;
3Солиев Алишер Кадырович - кандидат медицинских наук, ассистент, кафедра врачей общей практики № 1, Андижанский государственный медицинский институт, г. Андижан, Республика Узбекистан
Аннотация: в этой научной статье в основном изучается липидный спектр и метаболизм жирных кислот у пациентов с диагнозом безболезненной ишемии миокарда. Обследовано 37 пациентов, разделенных на 2 группы. I группа - контрольная (здоровые), II группа - пациенты с безболезненной ишемией миокарда. Результаты показали значительные изменения липидного профиля и увеличение жирных кислот у пациентов с безболезненной ишемией миокарда. Безболезненная ишемия миокарда характеризовалась острыми нарушениями липидного обмена у пациентов с диагнозом: U, повышенный AI и пониженный. Ключевые слова: атеросклероз, липидный спектр, жирные кислоты.
UDC 616.12-008.1-072.7
Introduction: Cardiovascular pathology associated with atherosclerosis has been a pandemic since the middle of the twentieth century and has been one of the leading causes of morbidity and mortality. (Avvaliani V.M. et al., 2015).
Dyslipidemia may be of varying severity for patients in different subgroups, which is explained by the genetic characteristics of the patients and the associated co-morbidities. The development of UIC depends on the interaction of various genetic factors and the environment. In recent years, the problem of UIC has gained not only medical but also social significance due to the increase in the number of diseases, mortality, loss of ability to work of various ages and professions (Abdurahimov AA, Mamutov R.Sh. 2001; Akimova EV, Kuznetsov V.A., Gafarov V.V., 2006; Alekseev V.G., Ivanov K.I., Konstantinov V.V., 2011).
As you grow older, the absolute risk of contracting HIV increases. Old age is one of the direct risk factors for UIC (Jamolov TN, 1984). UIC is the leading cause of death from heart disease in 88% of cases in men older than 65 years and in 80% of women in this age group. According to the World Health Organization (WHO), in 1988 the number of elderly people over the age of 60 on Earth was 488 million. In 2005, the figure was 622 million. (Gilyarevskiy S.R., 2001). In many cases, UIC can develop due to the combined effects of risk factors, including an increase in the amount of low-density lipoproteins (PZLP) in the serum. Hereditary factors account for around 50% of the diversity of PZLP (Dobordjginidze L.M., 2000; Gratsiansky N.A., 2000). To study the metabolism of fatty acids in atherosclerosis, it is important to identify PNJN, MJK, NJK.
The lack of data in the study of the relationship between simultaneous lipid metabolism and fatty acid metabolism in modern medicine in atherosclerosis has aroused interest in our scientific work.
Objective: To study the relationship between lipid spectrum and fatty acid metabolism disorders in patients with painless myocardial ischemia.
Examination materials and examination methods: The controlled patients were always under medical supervision. The duration of the disease ranged from 1 to 18 years. Patients ranged in age from 29 to 59 years and 37 were screened. Patients also underwent clinical laboratory tests, ECG, X-ray examinations. Patients were divided
into 2 main groups during the examination. Group I - control group (15) healthy, group II - identified patients with painless myocardial ischemia (37). The spectrum of lipids is modern biochemical studied using an express analyzer ("Reflotron-Roche"). PZLP XS and ultra-low-density lipoprotein (LDL) cholesterol were determined according to W. Friedwald's formula PZLP XS, mmol / l = UXS- YUZLP XS- O'PZLP XS, UPZLP XS = mmol / l = 0.45 x TG. Additional PZLP XS / YUZLP XS comparison and atherogenicity index recommended by A. Klimov were determined according to the formula: AI = (UXS-YUZLP XS) / YUZLP XS.
In our study, when we examined changes in lipids in patients diagnosed with painless ischemia of the myocardium, it was found that total cholesterol (UXO) ranged from 3.0-5.4 mmol / l in healthy individuals. In group II patients, UXS - 60%; TG - 58.3%; PZLP - an increase of 69.1%; YUZLP - decreased by 15.9%; the atherogenic index was found to vary by 82% relative to the control group. Plasma sugar levels were found to be 47% higher in control group II than in control group, meaning that, according to numerous data, MAO activity may be qualitatively modified in concomitant pathologies due to overexpression of fat metabolism processes. In particular, in Group II, NJK increased by 31.5% compared to control. The amount of MNJK increased by 39.2% compared to the control. PNJK decreased by 19% compared to group I. These indicators can serve as a basis for us to predict the aggravation of pathological processes in cases of atherosclerosis. A study of serum MAO activity found a 57.5% decrease in patients with painless myocardial ischemia compared to healthy ones.
Analysis: Dyslipidemia and dyslipoproteinemia A are the main biochemical phenotypes. The lipid spectrum of the blood includes determination of UXS, TG, YUZLP XS, PZLP XS, O'PZLP XS, atherogenic index. The results obtained are characterized by a sharp disturbance of lipid metabolism in patients with A: UXS, PZLP XS, an increase in AI and a decrease in YUZLP XS. The incidence of hypercholesterolemia and hyperlipoproteinemia has been reported to increase concomitantly with increasing age of patients. It is known that dyslipidemia is a disorder of a large spectrum and is a direct cause of cardiovascular disease. When comparing the performance of patients in groups I and II, the absolute rates of patients with atherosclerosis were slightly higher, in which the main biochemical markers of Ani maximally elevated UXS -1.8-fold, PZLP -1.6-fold AI 1.5-fold higher than I-group.
Conclusion: Thus, the results obtained are characterized by a sharp disturbance of lipid metabolism in patients with painless ischemia of the myocardium: UXS, PZLP XS, AI elevation and YUZLP XS decrease. Significant increases in fat metabolism in patients lead to early development and aggravation of oxidative stress, as well as a sharp decline in antioxidant protection. We believe that our study will explain the causes of early development of atherosclerosis, at least for a while, and will allow early diagnosis of UIC and prevention of its complications.
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