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Abdullayeva Charos Abdudjalilovna, Yarmuhamedova Gulnora Khabibovna, Kamilova Umida Kabirovna, Madaminova Sayyora Abdujalilovna, Abduhalikov Oybek Ziyodulla ogli, Tashkent Institute of Postgraduate Medical Education, The Republican Specialized Scientific and Practical Medical Center of Therapy and Medical Rehabilitation, Tashkent Medical Academy,
Tashkent Medical College E-mail: [email protected]
ESTIMATION OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS
Abstract: In the development of CHF (chronic heart failure) attach importance to the violation of the diastolic function of the heart. Decreased myocardial compliance leads to an increase in the end-diastolic pressure, which can be detected at an early stage of heart failure even before the onset of systolic dysfunction. The mechanical properties of the myocardium, which are characterized by elasticity, compliance and stiffness, affect LV (left ventricle) filling processes: hypertrophy, fibrosis or myocardial infiltration increase its stiffness, which leads to a sharp increase in LV filling pressure. LV compliance decreases with dilatation [3, 5]. Violation of active relaxation is one of the earliest manifestations of myocardial dysfunction in most cardiovascular diseases. Fibrosis of the ventricular myocardium (increase in the content of collagen in them) is the most important risk factor for worsening heart function. Clinico-anatomical comparisons and experimental data on hypertensive rats show that the severity of fibrosis and the development of collagen in the myocardium corresponds to the severity of heart failure [1, 2]. Fibrosis is a determinant of myocardial stiffness and diastolic dysfunction, it also favors systolic dysfunction and arrhythmogenicity. Fibrosis is initially an adaptive process for necrosis after a heart attack, ischemia, and inflammatory processes in the myocardium.
Keywords:
The aim of the study. To study left ventricular remod- diastolic LV dysfunction have an important clinical signifi-eling processes in patients with postinfarction cardioscle- cance, since they indicate the degree of severity of diastolic rosis complicated by chronic heart failure. disorders contributing to the formation of CHF.
Materials and methods of research. We examined 219 Evaluation of the diastolic function indices showed
men with PICS, complicated with CHF, aged 40-60 years that in patients with CHF, the normal E/A values can (mean age 53.42 ± 6.2 years). Patients according to TSH be observed with increased values of the isovolumic re-according to the New York classification of cardiologists laxation time (IVRT) and the delay of the early diastolic are divided into the following FC of CHF: 31 (18.8%) filling (DT) of the left ventricle, which should be taken patients with I FC, 92 (36.6%) patients with II FC and into account when diagnosing.
96 (44.6%) patients with III FC CHF. Depending on the The analysis of the obtained results revealed the
severity of diastolic disturbances, three types of LV filling following types of diastolic LV disturbances: of 219 paare distinguished: delayed relaxation, pseudonormaliza- tients with CHF, relaxation disorders were determined in tion and restriction. Detection and analysis of variants of 48.4% of cases, pseudonormalization in 23.7%, restrictive
ESTIMATION OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS
changes in 15.1% of cases and normal diastolic function values in 12.4% (28) patients.
Patients, depending on the severity of diastolic dysfunction of the left ventricle, were divided into 3 groups:
1 (n = 106) - with relaxation disturbance, II (n = 52) -with pseudonormal type, III (n = 33) - with restrictive type of filling. To evaluate the relationship between left ventricular contractility and diastolic left ventricular dysfunction, 191 patients with CHF were divided into
2 groups: a group with preserved left ventricular systolic function (ejection fraction > 50%) and a group with a reduced ejection fraction < 50%).
An analysis of the prevalence of different types of diastolic left ventricular dysfunction showed that severe diastolic left ventricular function - pseudonormal and restrictive type - was significantly more frequent in the group of patients with reduced left ventricular systolic function. The analysis of the main indices of myocardial contractility and LV geometry in the examined patients, depending on the type of diastolic dysfunction, revealed that the volume parameters of the left ventricle - the end-diastolic volume and the end-systolic volume in the group with pseudonormal and restrictive type - were significantly higher in comparison with group of patients with disturbed relaxation. The PV index was also significantly lower in the group of patients with a restrictive type of LV diastolic dysfunction.
The diastolic function of the LV depends on both the relaxation of the myocardium and its mechanical properties. Relaxation of the myocardium of the LV is an active process, depending on the functioning of the sarcoplasmic reticulum of cardiomyocytes. As a rule, the basis of such CHF is the violation of diastolic LV function, i.e. his inability to adequately fill without increasing the average pulmonary venous pressure.
The results of epidemiological studies in recent years have shown that in 30-50% of patients with a clinically confirmed diagnosis of CHF, systolic cardiac function is preserved and an average of 3 to 20 people per thousand of the population have asymptomatic left ventricular dys-
function. According to the European Society of Cardiology (EOK), systolic dysfunction of the myocardium (without clinical signs of CHF) can reach 5-6% in the population, which makes up another 20 million in Europe with a population of about 900 million [7]. According to F. T. Ageeva [4, 6], the prevalence of I-FC CHF is 4 times greater than II-IV FC and more than 55% of patients with HF have practically normal myocardial contractility and the number of such patients will increase steadily. An analysis of the prevalence of different types of diastolic left ventricular dysfunction showed that severe diastolic left ventricular function - pseudonormal and restrictive type - was significantly more frequent in the group ofpa-tients with reduced left ventricular systolic function. The analysis of the main indices of myocardial contractility and LV geometry in the examined patients, depending on the type of diastolic dysfunction, revealed that the volume and geometric parameters of the left ventricle in the group with pseudonormal and restrictive type were significantly higher in comparison with the group of patients with disturbed relaxation. The results are consistent with data from multicenter studies of PEP-CHF, CHARM, Aldo-DHF, which show the prognostic significant role of diastolic dysfunction in patients with CHF.
Postmyocardial LV leads not only to LV structural reorganization, accompanied by dilatation of the cavity, thinning of the wall, a decrease in the contractility of the myocardium, but also to a change in the geometric shape of the LV. LV remodeling in patients with CHF was characterized by a violation of the diastolic function of the heart, which manifested itself more in violation of relaxation. An analysis of the prevalence of different types of diastolic left ventricular dysfunction showed that severe diastolic left ventricular function - pseudonormal and restrictive type - was significantly more frequent in the group of patients with reduced left ventricular systolic function. With the progression of the disease, there was an increase in the number of patients with an eccentric type of remodeling, as well as a restrictive type of diastolic LV dysfunction.
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