CC BY
20
тезисы 15-го юбилейного съезда ногр... | abstracts 15th anniversary congress "gssr".
Lactobacillus rhamnosus, Lactobacillus acidophilus DDS-1 and Bifidobacterium bifidum during one month; Group II: PPIs and probiotics once daily and alkaline hydrocar-bonate-chloride sodium mineral water Essentuki-4200 ml trice daily during one month; Group III: PPIs and probiotics once daily and chloride sodium mineral water Minsk-4 200 ml trice daily during one month; Group IV: probiotics and PPIs once daily during one month. Therapeutic success was confirmed by a negative histological examination and Breath HELIK-Test, performed in 4-12 weeks after therapy.
Findings. In Group I dyspeptic complaints disappeared in 74 %, and decreased in 20 %. Disappearance of dyspeptic complaints was 78 %, 76 % and 74 % in II, III and IV groups respectively. Decrease of dyspeptic complaints was 20 %, 22 % and 24 % in II, III and IV
groups respectively. The eradication rates were 82 %, 80 %, 78 % and 68 % in I, II, III and IV groups, respectively. Healing of duodenal ulcer was noted in 84 %, 86 %, 84 % and 78 % of cases, in I, II, III and IV groups, respectively. Intragastric and intraduodenal pH was significantly increased in all groups, especially in II. After treatment in II, III and IV groups significantly decreased alanine transaminase, asparagines transaminase, blood bilirubin, alkaline phosphatase, cholesterol and triglycerides.
Conclusions. Adding probiotics to standard triple therapy improves efficacy of eradication. The combined use of PPIs, probiotics and alkaline hydrocarbon-ate-chloride sodium mineral water is a highly-effective alternative therapy in patients with Hp-associated duodenal ulcer.
129. Elaboration of optimal Helicobacter pylori erai
Rustamov M. N.
Belarusian State Medical University, Minsk, Belarus
Purpose: to investigate the efficacy of proton pump inhibitors (PPIs), probiotics and different mineral water in patients with Helicobacter pylori (Hp) -positive duodenal ulcer and to elaborate the optimal Hp eradication regimens in such patients.
Material and methods. In this study 250 Hp-positive patients with duodenal ulcer were randomized into 5 groups, 50 patients in each. Hp infection was confirmed by a histological examination of samples obtained from the antrum and corpus of stomach during endoscopy and non-invasive Breath HELIK-Test. Intragastric and intraduodenal pH-metry, blood analyses also were performed. The following eradication regimens were recommended: Group I: 10-days twice daily oral administration of PPIs in standard dose, amoxicillin 1000 mg, clarithromycin 500 mg, then 20-days twice daily PPIs; Group II: the same treatment plus once daily oral administration of probiotics, containing Lactobacillus bulgaricus DDS-14, Lactobacillus rhamnosus, Lactobacillus acidophilus DDS-1 and Bifidobacterium bifidum during one month; Group III: PPIs and probiotics once daily and alkaline hydrocarbonate-chloride sodium mineral water Essentuki-4 200 ml trice daily during one month; Group IV: PPIs and probiotics once daily and chloride sodium mineral water Minsk-4 200 ml trice daily during one month; Group V: probiotics and PPIs once daily during one month. Therapeutic success was confirmed by a negative histological examination and Breath HELIK-Test, performed in 4-12 weeks after therapy.
Findings. 82 % of patients had pain syndrome and 70 % — dyspeptic complaints. In 50 % of patients of group I increased the frequency of dyspeptic complaints and in 42 % of them such complaints appeared
regimens for patients with duodenal ulcer
for the first time. In Group II dyspeptic complaints disappeared in 74 %, and decreased in 20 %. Disappearance of dyspeptic complaints was 78 %, 76 %, 74 % in III, IV and V groups respectively. Decrease of dyspeptic complaints was 20 %, 22 %, 24 % in III, IV and V groups respectively. The eradication rate of Helicobacter pylori were 70 %, 82 %, 80 %, 78 % and 68 % in I, II, III, IV and V groups, respectively. Healing of duodenal ulcer was noted in 82 %, 84 %, 86 %, 84 % and 78 % of cases, in I, II, III, IV and V groups, respectively. Intragastric and intraduodenal pH was significantly increased in all groups, especially in III. After treatment in group I significantly increased alanine transaminase, asparagines transaminase, alkaline phosphatase, and triglycerides, which must be noted as drug-related side effects of clarithromycin-based triple therapy. In group II such changes did not happen. In III IV and V groups significantly decreased alanine transaminase, asparagines transaminase, blood bilirubin, alkaline phosphatase, cholesterol and triglycerides.
Conclusions. Standard clarithromycin-based triple eradication therapy causes or increases the frequency of dyspeptic complaints related with antibiotics has low efficacy and hepatotoxic effect. Adding probiotics to standard triple therapy improves efficacy of eradication. The combined use of PPIs, probiotics and alkaline hydrocarbonate-chloride sodium mineral water is a highly-effective alternative therapy in patients with Hp-associated duodenal ulcer. This regimen may especially be helpful in patients with a history of gastrointestinal adverse effects with antibiotics, comorbid patients with diseases of the hepatobiliary system and the metabolic syndrome.
130. Effect of probiotics different groups to reparations colonic mucosa in patients with acute infectious and post-infectious colitis
Shcherbakov I. T., Leontiev N. I., Grachev N. M., Solovyov A. I., Khrennikov B. N.
Moscow Institute of Epidemiology and Microbiology G. N. Gabrichevskogo, Russia, e-mail: [email protected]
Objective: to examine the state of the colonic mucosa and Post-colitis treated with a combined therapy of (CM) in patients with acute intestinal infections (AII) probiotic preparations of different groups.
экспериментальная и клиническая гастроэнтерология | выпуск 117 | № 5 2015
информация | information
Material and methods. We observed 137 patients with various diseases (shigellosis — 18, salmonellosis — 26, campylobacteriosis — 28, rotavirus gastroenteritis — 31 and chronic post-infectious colitis — 34) treated with different (mono- and bi-component) pro-biotic preparations (bifikol, bifiliz, bifidumbakterin forte, laktobakterin and hilak forte) in the complex basic therapy. The diagnosis is made based on a comprehensive clinical and laboratory research: endoscopy (sigmoidoscopy with biopsy CM), histological, histo-chemical, morphometric (24 objective indicators) and microscopy (detection of Campylobacter in biopsies according rationalization proposals from 1990) and statistical (determination of the coefficient of reliability t>2 confidence interval and p<0,05; p<0,01 and p<0,001).
The Results. The results showed a marked positive effect of probiotics on repair processes in the CM in patients with different diseases. Application Bifikol patients shigellosis, salmonellosis Bifiliz patients, in patients with campylobacteriosis bifidumbacterin, lak-tobakterina and Hilak forte in patients with rotavirus gastroenteritis decreased the inflammatory changes (p<0.01), cellular infiltration of surface and pit epithelium (p <0.05), accelerated repair processes in the CM (p<0,05). In addition, bifidumbakterin provided sani-fying influence in the CM patients campylobacteriosis.
Conclusions. The inclusion of probiotic preparations ofdifferent groups in the complex therapy ofpatients with acute and chronic diseases ofthe gastrointestinal tract has a positive effect on the repair processes, reduces inflammatory changes and has sanifying impact on the weave.
131. The dependence of the level of health on chronobiological type of person
Shemerovskii K. A., Mefodovskiy M. A.
Federal Institute of experimental medicine, St. Petersburg, Russia, e-mail: [email protected]
Methods. Biological chronotype: Larks (L), Doves, (D), Owls (O) was determined by the Ostberg test. Health, Activity and Mood were determined by the test SAN. Just tested 63 persons: 22 men and 41 women, 16-17 years. Regular circadian bowel rhythm was detected at frequency 7 times a week, irregular one at 1-6 times a week.
Results. The level of health in L: D: O was 76 %:75 %:73 % of optimal. Breath test in L was on average 62 s, in D — 56 s and in O — 48 seconds. Morning
bowel acrophase was detected in 20 % of Larks, in 16 % of Doves and in 0 % of Owls. The morning (physiological) acrophase was identified in 36 % of individuals with a regular bowel rhythm. The morning acrophase met in 10 % of individuals with irregular bowel rhythm.
Conclusions. 1. The level of health depends on chronobiological type ofperson: in Larks it was higher than in Owls. 2. The higher the level ofhealth, the more likely is the morning acrophase bowel rhythm.
132. Features genetic polymorphism HLA-antigens of Crohn's disease in adults Russian population Moscow region
Stavtsev D. S.1, Astrelina T. A.2, Azova M. M.3, Lebedeva L. L.1, Pukhlikova T. V.1, Chumak A. A.1, Knyazev O. V.4
1 Blood transfusion station of the Department of Health of the City of Moscow; 2State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; 3Peoples' Friendship University of Russia; 4Moscow Clinical Research Center, Moscow, Russia.
Aim: to study HLA-antigens of predisposition to the development and protection for Crohn's disease in adults russian population Moscow region.
Material and methods. The study included 53 samples of peripheral blood ofpatients with Crohn's disease in Moscow region. The control group was represented by 1,700 samples of umbilical cord blood is healthy newborns. Revealing HLA antigens at low level performed by SSO method on DynalRELI 48 processor. The results were using PCR-SSP method (Ivitrogen) with ambiguous interpretation.
Results. Were found the positive and negative associations of groups of HLA alleles with clinical form, the course of Crohn's disease and response to steroid treatment, in particular revealed that, predisposition
to the development for Crohn's disease in women and with sensitivity to steroid treatment in this disease associated allele group C*12, to the characteristic restricting markers such as Crohn's disease include the B 38 and A*11 markers nonrestricting, nonpenetrating noninflammatory type groups are alleles B*56 and C*14 and C*14 is also associated with the risk of Crohn's disease in men, characteristic markers of protection to the development of the disease crown with chronic relapsing and severe clinical course are DQB1*02 and DQB1*03, respectively.
Conclusion. These results demonstrated the need for studies of gene polymorphism HLA-system, not only in relation to the disease in general, but in selected patients with clinical groups.
133. Immunogenetic markers inflammatory bowel diseases in adults Russian population Moscow region
Stavtsev D. S.1, Astrelina T. A.2, Azova M. M.3, Lebedeva L. L.1, Pukhlikova T. V.1, Chumak A. A.1, Knyazev O. V.4
'Blood transfusion station of the Department of Health of the City of Moscow; 2State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; 3Peoples' Friendship University of Russia; 4Moscow Clinical Research Center, Moscow, Russia.
Aim: to study immunogenetic markers ofpredisposition bowel diseases (IBD) in adults Russian population to the development and protection for inflammatory Moscow region.
