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Незважаючи на те, що в щурiв iз ЦД в обидва термши постiшемiчного перiоду вмiст РНК зростав на тлi посилення проапоптично! активносл, це зро-стання, особливо в тзньому термiнi спостере-ження, за абсолютними показниками було значно меншим, нiж у тварин без ЦД.
Висновок. У тварин без дiабету активащя проапоптично! активностi у вщповвдь на шемш-репе-рфузiю супроводжуеться паралельним зростанням процесiв синтезу в клггинах гiпокампа. За умов дiа-бету в пiзньому постiшемiчному перiодi активнiсть процесiв синтезу значно нижча, шж процесiв апоп-тозу.
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1. Скибо Г.Н. Использование различных экспериментальных моделей для изучения клеточных механизмов ишемического поражения мозга / Г.Н. Скибо // Патология. - 2004. - Т.1, №1. - С. 2230.
2. Пирс Э. Гистохимия / Э. Пирс М.: Изд-во ин. лит, 1962. - 962 с.
3. TranyK C.C. EKcnpecia öwkib Hif-1a, p53 Ta Bcl-2 b ro^OBHOMy M03Ky 3a yMOB gBo6iHHoi' KapoTHg-Hoi' imeMü'-penep$y3ii Ha rai цyкpoвoгo gia6eTy b caM^B-^ypiB / C.C. TKanyK, O.M. HeHbKOB // K^iHiHHa Ta eKcnepuMenraibHa naTOnoria. - 2010. -T.IX, №2(32). - C.111-113.
4. Diabetes mellitus: a risk factor for ischemic stroke in a large biracial population / J.C. Khoury, D. Kleindorfer, K. Alwell [et al.] // Stroke. - 2013. -Vol.44, №6. - P. 1500-1504.
5. Identifying Target Risk Factors Using Population Attributable Risks of Ischemic Stroke by Age and Sex / T.H. Park, Y. Ko, S.J. Lee [et al.] // J. Stroke. -2015. - Vol.17, №3. - P. 302-311.
6. Kolesnik Y.M. Image analysis system for quantitative immunofluorescence measurement / Y.M. Kolesnik, A.V. Abramov // Microscopy and Analysis. - 2002. - № 5. - P. 12-16.
7. Konig J. F. The rat brain. A stereotaxis atlas of forebrain and lower part of the brain stem / J. F. Konig, P. A. Klippel. - Baltimora: The Williams and Wilkins Company, 1963.- 162 p.
DYNAMICS OF THE HEALTH AND DEMOGRAPHIC INDICES OF THE POPULATION OF THE DISTRICT OF PLOVDIV
Shopov Dimitar Georgiev
MD, PhD, Chief Assistant Prof. Department of Social Medicine and Public Health Medical University - Plovdiv, Bulgaria Mihaylova Vanina Krasteva PhD, Assoc. Prof. Department of Preventive Medicine, Faculty of Public Health, Sofia; Chief Assistant Department of Healthcare Management, Faculty of Public Health,
Medical University, Plovdiv, Bulgaria
Summary:
The geo-demographic situation on the territory of the district of Plovdiv experiences the influence of multiple factors. Among them are, on the one part, the historical and cultural, socio-economical and demographic development of the country, and the specific influence of the marriage, divorce, birth and death rates, migration, gender and age, ethnic, religious and educational structures of the population, specific to this territory.
The present article analyzes the health and democratic indices of the population in the district of Plovdiv over a 6-year period from 2010 to 2015 inclusive. The following facts have been established:
S The process of demographic aging continues.
S Plovdiv district is in a state of depopulation.
S Children's mortality rate in the district of Plovdiv is still high, compared with the data for the country.
S The main causes of death in the district of Plovdiv are diseases of the circulatory system and neoplasms.
S Plovdiv district ranks second according to morbidity rate and fourth according to sick rates from malignant neoplasms.
S Plovdiv district occupies the first place according to the number of hospital beds per capita.
S The procurement of medical specialists in the district of Plovdiv exceeds the average for the country.
Key words: population, demographic indices, birth rate, death rate, natural increase in population, malignant diseases
Introduction:
Demography is a science of the population. In the contemporary stage of its development, demography has many specialized methods of input data processing, obtained mainly in the governmental statistics system.[1;2]
The results of the demographic analysis show the trends of the demographic development in its different aspects - regarding birth rate, death rate, marriage rate, divorce rate, migrations, etc.[4] The interpretation of those results in connection with the development of other social spheres, the drawing of realistic prognoses, conclusions and recommendations towards the social practice and policy - all this requires the knowledge of the main theories of the population within the soci-ety.[5;7]
The development of the demographic science and practice does not stop on the level of demographic analysis, it relates to social problems which in any case comprise the demographic process, the important decisions determining the road of life of each person, form the so called demographic behaviour.[9;11] On the basis of demographic data and computations conclusions about important tendencies in the social development can be drawn, certain socially significant processes can be foreseen and emerging or forthcoming tensions and conflicts can be overcome.[12] The studies in the social sphere, the development of economic projects and larger-scaled undertakings usually start with clarification of the demographic situation.[13]
Objective of the present article is the study of some demographic indices of the population in Plovdiv district.
Materials and methods:
The subject of observation is Plovdiv district. The logical unit is the population of Plovdiv district. The survey is retrospective over a 6-year period from 2010 to
The long-lasting tendency of prevailing of the relative share of women (52%) over men (48%) is still preserved.
The age structure of the population in Plovdiv district corresponds to the general specification of the Re-
2015 inclusive. Quantitative and qualitative indices have been used for the analysis. The primary information has been derived from the annual reports of the National Statistical Institute, the Ministry of Health and the Regional Health Inspection of Plovdiv. For the statistical processing of the collected primary information the variational, alternative and non-parametric analyses have been used. The computer processing of the collected data base involved the use of the statistical package SPSS version 19 and MicrosoftExcel
Results and discussion:
Plovdiv district is located in the central part of Southern Bulgaria, occupying an area of 5972.9 sq.m., equal to 5.4% of the territory of the Republic of Bulgaria. It is one of the regions most favoured by nature. The district has a convenient transport geographic location, has a high natural, economic and human potential, favourable bioclimatic resource, high-productive cultivated lands, thermal mineral water, very rich cultural heritage. The favourable geographic location of the district is supplemented by the availability of an established infrastructure for transport access. The territory of the district comprises the southern slopes of the Balkans, the Pazardzhik-Plovdiv field, the forest massive of Sredna Gora and the Northern Rhodopes, mountain river valleys and rivers. In a climatic aspect the region is not homogeneous - in the flat areas it is transitional continental and in the high areas - mountainous.
The population of Plovdiv district as of 31 December 2015 amounts to 673283 people and constitutes 9.41% of the population of the country. As of 31 December 2015, the population of Bulgaria was 7 153 784 people.
There is a decrease in the population in the district -from 696300 in 2010 to 673283 in 2015 (Chart 1).
Chart 1
public of Bulgaria (Chart 2). The process of demographic aging continues. Within the 6-year period of observation the following facts have been reported:
> Children and juveniles have a relatively permanent number in the observed period of time.
> The number of people within the age range 2064 reduces: from 443342 in 2010 to 411816 in 2015 -31 526 people less. (4.67% of the total number of the population).
The people living in the cities within the district constitute 74.9% while those in the villages - 21.5%.
The tendency of birth rate in the district of Plovdiv marks a downward trend: from 10.3%o in 2010 to 9.9 %o in 2015. The birth rate is significantly influenced by the share of women at childbearing age, which decreases.
The total mortality rate in the district has an upward tendency from 13.9%o in 2010 to 14.7%o in 2015. The male mortality rate is 15,9%o and as a permanent tendency it is higher than the female mortality rate - 13,7%o.
The main reason for the deaths during the analyzed period of time (2010-2015) in the district of Plovdiv remains the diseases of the blood circulation organs, with intensity of 935.7 per one hundred thousand
> The relative share of elderly people aged 65 and more increases from 124 055 in 2010 to 136690 in 2015 - 12635 people more (1.87% of the total number of people).
Chart 2
The unfavourable dynamics of births and deaths leads to decrease in the natural growth of the population which has a permanently negative value in the analyzed time period (2010-2015 inclusive). Last year the natural growth rate in the district was (-4.8) (Table 1).
Table 1
people of the population in 2015, marking an upward trend during the observed time span (Table 2).
The deaths due to new formations with intensity of 270.6 per one hundred thousand people in 2015 occupy the second place.
The list of causes of death is supplemented by: diseases of the digestive system, diseases of the respiratory system, external causes of morbidity and mortality, signs and deviations of the standard, found during clinical tests, not classified anywhere else.
Table 2
per 100
Causes of death, International classification of diseases - 000
X revision, people
2010 2011 2012 2013 2014 2015
Class II Neoplasms (C00-D48) 268,4 279,6 291,8 293,1 279,4 270,6
Class IX Diseases of the circulatory system (I00-I99) 879,7 900,1 935,8 846,2 883,6 935,7
Class X Diseases of the respiratory system (J00-J99) 42,3 33,3 32,8 46,1 59,5 52,6
Class XI Diseases of the digestive system (K00-K92) 51,1 44,9 48,4 56,3 60,3 70,3
Class XX External causes of morbidity and mortality (V01-Y98) 60,1 44,7 34,1 29,9 47,1 52,8
Age group
ШШШ
2010 2011 2012 2013 2014 2015
ii 0-19years 128903 124376 123850 123632 123814 124777
■ 20-64years 443342 426614 424008 421903 417000 411816
■ 65+years 124055 129894 131002 132662 134737 136690
Natural growth in population rate Total death rate Death rate in men Death rate in women
2010 -3,6 13,9 15,3 12,6
2011 -3,8 13,8 15 12,6
2012 -4,5 14,3 15,6 13
2013 -4 13,6 14,9 12,4
2014 -4,3 14,1 15,2 13,1
2015 -4,8 14,7 15,9 13,7
