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DORSOPATHIES: ROUTINE CHECKUPS AS A PROCEDURE NECESSARY FOR EARLY DIAGNOSTICS, RISK FACTORS AND COMORBIDITIES IDENTIFICATION
Denisov IN1, Zaugolnikova TV1, Popova TS1,2 Morozova TE1
1 Department of General practice,
Sechenov First Moscow State Medical University (Sechenov University), Moscow
2 First Doctor clinic, Moscow
Early detection of dorsopathies is an urgent task for primary care physicians, since such conditions can combine with other chronic noncommunicable diseases (NCD) and adversely affect the course all comorbidities, consequently disimproving the quality of life of patients and increasing the frequency of their requests for medical assistance. This study aimed to determine the value of routine checkups in the context of detection of dorsopathies, NCD, and identification of risk factors (RF). We have retrospectively analyzed the patient records database of a rural outpatient clinic in the Tver region (years 2015 to 2017). The prevalence of dorsopathies and NCD RF were the subjects investigated. Fisher's exact test and Spearman's rank correlation coefficient (SRCC) were applied for the purposes of statistical processing of the results. We discovered that dorsopathy most often was a comorbidity to arterial hypertension and gastrointestinal tract diseases; it was strongly related to the NCD (SRCC = 0.506), age (SRCC = 0.383), slightly less so — to hypodynamia (SRCC = 0.146), type of the patient's occupation (intellectual or physical labor) (SRCC = 0.07). Routine checkups improve the rate of detection of dorsopathy: the more patients undergo such examinations, the more cases of dorsopathy are diagnosed. Thus, it is necessary to increase the number of working people attending the checkups in order to detect dorsopathies early and prevent them effectively.
Keywords: preventive medical examination, dorsopathy, risk factors, comorbidity, village resident.
Acknowledgment: authors of the study express their gratitude to L.V Tyazhelova, head physician of the Mokshino outpatient clinic (Konakovo district, Tver region) for assistance in collecting material for the article and providing a room to work with the papers
gg Correspondence should be addressed: Tatyana S. Popova Severny Boulevard, 7B, Moscow, 127566; bluesfinks@mail.ru
Received: 06.09.18 Accepted: 05.11.18
DOI: 10.24075/brsmu.2018.065
ДОРСОПАТИИ: АКТУАЛЬНОСТЬ ПРОФИЛАКТИЧЕСКИХ ОСМОТРОВ ДЛЯ РАННЕЙ ДИАГНОСТИКИ, ВЫЯВЛЕНИЯ ФАКТОРОВ РИСКА И КОМОРБИДНЫХ ЗАБОЛЕВАНИЙ
И. Н. Денисов1, Т. В. Заугольникова1, Т. С. Попова1,2 Т. Е. Морозова1
1 Кафедра общей врачебной практики,
Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет), Москва
2 ООО Клиника «Первый доктор», Москва
Лечебно-профилактические мероприятия по ранней диагностике дорсопатий являются актуальной задачей врачей первичного звена здравоохранения. Это обусловлено тем, что сочетание дорсопатий с другими хроническими неинфекционными заболеваниями (ХНИЗ) формирует коморбидность, которая неблагоприятно влияет на их течение и исходы, увеличивает обращаемость населения за медицинской помощью, ухудшает качество жизни пациентов. Целью работы было определить значение профилактических осмотров в диагностике дорсопатий, сопутствующих ХНИЗ, и выявлении факторов риска (ФР). Проведен ретроспективный анализ базы данных амбулаторных карт пациентов сельской амбулатории Тверской области за 2015-2017 гг. Исследовали распространенность дорсопатий и ФР ХНИЗ. При статистической обработке применяли точный критерий Фишера и коэффициент ранговой корреляции Спирмена (КРКС). Было показано, что дорсопатия чаще всего сочеталась с артериальной гипертензией и заболеваниями желудочно-кишечного тракта, имеет сильную корреляционную связь с сопутствующими ХНИЗ (КРКС = 0,506); возрастом (КРКС = 0,383); более слабую с гиподинамией (КРКС = 0,146) и слабую с видом деятельности пациента (интеллектуальным или физическим трудом) (КРКС = 0,07). Профилактические осмотры улучшают диагностику дорсопатии — число выявляемых случаев заболевания растет с увеличением количества обследуемых в рамках профилактических осмотров пациентов. Таким образом, необходимо шире проводить профилактические осмотры для работающего населения с целью раннего выявления дорсопатии и эффективной ее профилактики.
Ключевые слова: профилактические осмотры, дорсопатия, факторы риска, коморбидность, жители села
Благодарности: главному врачу Мокшинской амбулатории Конаковского района Тверской области Л. В. Тяжеловой за содействие при сборе материала для статьи и предоставление помещения для работы с документацией.
gg Для корреспонденции: Татьяна Сергеевна Попова
Северный бульвар, д. 7Б, г Москва, 127566; bluesfinks@mail.ru
Статья получена: 06.09.18 Статья принята к печати: 05.11.18
DOI: 10.24075/vrgmu.2018.065
World Health Organization (WHO) announced prevention and treatment of noncommunicable chronic diseases (NCD) a priority project of the second decade of the 21st century, one aimed at improving the quality of life of the world's population [1]. There are two directions to the project: 1) healthy lifestyle education and promotion and 2) early detection of NCDs, learning the relevant risk factors (RF) and their timely correction. It is the healthcare systems of the countries that ensure progress in the second direction, with primary care physicians — district doctors, general practitioners (family doctors) — playing a special role: 30-40% of their working time should be dedicated to activities aimed at prevention [2].
Diseases of the musculoskeletal system and connective tissue (DMSCT) are common; there are over 150 different conditions and syndromes belonging to the group, most of which usually cause pain and musculoskeletal system dysfunction. In the developed countries, the average age of people living in densely populated areas increases, which makes DMSCTs a frequently registered trigger of disability. In 2000, WHO launched The Bone and Joint Decade 20002010, the goal of which was to increase the awareness of the existing problem throughout the world. Some of the initiatives undertaken within the decade implied studying medical, social and economic load born by the society in connection with the musculoskeletal system disorders, comprehensive understanding of RF affecting development and progression of musculoskeletal pathologies, as well as comorbidities [3]. According to the data published in 2016, every third European citizen complaining of pain in muscles, bones and joints, has limited ability to move the limbs, with the share of people affected ranging from 18% in Ireland to 46% in Croatia [4]. Lower back pain is the most common complaint (11% of all patients). People 55 years of age and older suffer pain twice as often. Women have the condition more often than men: 37% and 27%, respectively [4].
Demographic changes (population ageing) and lifestyle-related RFs of NCDs allow forecasting the further spread of the pathologies belonging to this group. DMSCT are often accompanied by the cardiovascular diseases. Such comorbidities are always a complicated case, which is one of the reasons of the increased mortality rate among patients suffering them [5, 6].
This study aimed to determine the value of routine checkups in the context of early detection of dorsopathies, NCDs and their risk factors (RF).
METHODS
The subject of this research were reports made at Mokshino rural outpatient clinic and covering two districts (general practitioners) of Konakovo district of the Tver region. Namely, we studied the main indicators for 2011-2016: annual reports (forms 30, 12), "Outpatient medical history records" (UF #025/u); "Routine checkup control records" (UF #030/u);
"Additional checkup registration records (working citizen)" (UF #131/u-DD-10) and other record forms related to preventive and additional medical examinations of working population. We have retrospectively analyzed the 2015-2017 patient records database. 1203 records containing a dorsopathy diagnosis were selected for the purposes of analysis of age-related specifics of comorbidities' development. Inclusion criteria: men and women aged 18 years and older, diagnosed with dorsopathy, signed the informed consent.
Exclusion criteria: age below 18, no dorsopathy in the anamnesis. Time of first complaints, dorsopathy diagnosis date, presence of RF and comorbidities peculiar to these patients were analyzed.
The study protocol #10-16 of 11/09/2016 was approved by the local ethics committee of Sechenov University. Dividing the patients into groups and categories, we used the classification developed by WHO: young (18-44 years), middle-aged (44-60 years), senior (60-75 years), old-aged (75-90 years), long-livers (90+ years).
Diagnostic criteria recommended by Appendix #2 to the Order #1006n of 03.12.2012 issued by the Ministry of Health of Russia were referred to when determining the RF and pathological conditions and diseases.
Statistical processing
Planning the study, we determined the size of the sample to be taken from the Mokshino outpatient clinic's database with the help of the Sample Size modules of COMPARE 2 3.85 and DESCRIBE 3.18 programs of WinPEPI© 11.65 software package (author and copyright holder — J. H. Abramson). Fisher's exact test was applied in the context of statistical processing of the results. Investigating the relations between dorsopathy, RF, other NCDs, we used SRCC. The statistical significance threshold was set at 5%.
RESULTS
The number of patients diagnosed with dorsopathies grows proportionally to the number of those undergoing routine checkups, even with the number of visits to the outpatient clinic and the number of patients registered at the clinic decreasing (by 2.6% (159 people) and 1.6% (35 people), respectively) (see Table, Fig. 1 and 2).
Figure 3 shows the presence of NCDs RFs in lives of 1203 rural residents (540 men and 663 women). The most common RFs for men were smoking (73%) and hypercholesterolemia (17.3%). The predominant RF for women was excess body weight (39.8%).
Arterial hypertension (AH) was the most widely-spread condition: 516 patients (42.9% of all examined, 42,892.76 cases per 100,000 people) suffered from it, including 207 men (38.3% of all men examined) and 309 women (46.6% of all women examined). The gender differences are statistically significant
Table. Routine checkups and detected cases of dorsopathy in numerical terms, adults, Mokshino outpatient clinic, 2011-2016
Indicators Reporting period, year
2011 2012 2013 2014 2015 2016
Number of people registered 2237 2216 2217 2206 2217 2202
Number of visits to the clinic 6122 6640 5587 5963 6784 5963
Number of routine checkups 1033 1128 1033 1493 1776 1493
Diagnosed dorsopathies (# of people) 257 253 281 299 327 347
Number of dorsopathy patients in follow-up care at the end of the reporting year 257 263 280 299 324 345
(p = 0.004). From the point of view of prevalence, dorsopathy was next to arterial hypertension: it was detected in 347 patients (28.8% of all examined ), which translates into 28,844.56 cases per 100,000 people; they were 147 men (27.2% of all men examined) and 200 women (30.2% of all women examined). Here, gender differences were not statistically significant (p = 0.004). Gastrointestinal tract diseases (except for gastric ulcer and duodenal ulcer) followed dorsopathies: such were detected in 141 patients (11.7% of all examined, 11,720.69 cases per 100,000 people), including 44 men (8.1% of all men examined) and 97 women (14.6% of all women examined). The gender differences are statistically significant (p = 0.004; Fig. 4). In 2016, dorsopathy was diagnosed in 82 young people (18-44 years old), which is 23.9% of all dorsopathy patients; in the middle-aged group (44-60 years), there were 127 cases (36.6%), and in the senior (60-75 years) and further groups dorsopathy diagnosis was announced to 137 (39.5%) persons.
In different years from 2011 to 2016, 99.1 to 100% of dorsopathy patients were observed by the Mokshino outpatient clinic's general practitioner (see Table).
In 31.7% of patients, dorsopathy was the only disease; in 28.5%, it combined with one other disorder, in 40% dorsopathy had two comorbidities (percentages of the total number of dorsopathy patients).
Two most frequent comorbidities were arterial hypertension (191 cases, 55.0% of all dorsopathy patients) and gastrointestinal tract diseases except for gastric ulcer and duodenal ulcer (67 cases, 19.3% of all dorsopathy patients). Less common diseases diagnosed together with dorsopathy were coronary heart disease (33 cases, 9.5% of all dorsopathy
patients), obesity (27 cases, 7.8% of all dorsopathy patients), diabetes mellitus (20 cases, 5.8% of all dorsopathy patients), gastric ulcer and duodenal ulcer (17 cases, 4.9% of all dorsopathy patients), chronic diseases of the respiratory system (15 cases, 4.3% of all dorsopathy patients). Women suffer the aforementioned comorbidities (except for the coronary heart disease) more often than men. Significantly more women had diabetes mellitus and obesity as comorbidities of dorsopathy than men: 8.0% against 2.7% with diabetes, 12.5% against 1.4% with obesity, respectively. Coronary heart disease was detected in patients with dorsopathy in equal proportions gender-wise (9.5%).
SRCC values for dorsopathy and NCDs' RF peculiar to the population group of rural residents studied are shown on Fig. 2 (2016). NCDs and age (SRCC values of 0.506 and 0.383, respectively) correlate with dorsopathy more often than any other factor. Hypodynamia's correlation is weaker (SRCC = 0.146), that of the type of the patient's occupation (intellectual or physical labor) — even less so (SRCC = 0.07). As for the inverse correlation ties, the strongest was with simple absence of any comorbidity (SRCC = -0.406), a weaker one — with alcohol abuse (SRCC = -0.006). In the studied sample of dorsopathy patients (347 people), gender differences were not statistically significant (p = 0.004).
DISCUSSION
In 2016, DMSCTs (as described by ICD 10: M00-M99, dorsopathy included) incidence in Russia was 2,953.2 cases per 100,000 people nationwide and 9,402.5 cases per 100,000
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2000 3000 4000 5000 6000 Number of visits to the outpatient clinic, adults Fig. 2. Dot diagram reflecting distribution of the number of dorsopathy patients and number of visits to the Mokshino outpatient clinic (adults, 2011-2016)
rural residents. In the Central Federal District, the figure was 8,707.4 cases per 100,000 rural residents. In the Tver region in 2016 — 11,179.5 cases per 100,000 rural residents [7]. Thus, dorsopathy incidence as registered by the Mokshino outpatient clinic in 2016, which is 28,844.56 cases per 100,000 people, is 3.1 times higher than the statistically average incidence of DMSCTs detected in residents of the rural areas of Russia; as for the Central Federal District's rural population, the Mokshino figure is 3.3 times greater. The number of rural residents beyond employable age has grown by 2.5% in the period between 2004 and 2013 in Russia, and continues to grow [8]. Tver region is one of the national leaders by the number of such residents living there (in %); in the Central Federal District, it ranks 2nd (as of January 1, 2016) with 32.4% people living outside of cities being beyond working age [9]. Population ageing can be the explanation of high incidence of dorsopathy in the studied population group: out data indicates that age and dorsopathy have the strongest intercorrelation (SRCC = 0.383; Fig. 4).
Dorsopathy incidence as registered by the Mokshino outpatient clinic in 2016, which is 28,844.56 cases per 100,000 people, is 2.6 times higher than Tver region average as reported by Rosstat (DMSCTs, rural population). [7]. Such figures call for further research of the disease and identification of the causes of its spread in this population.
At the international level, there is no single generally accepted dorsopathy definition and assessment routine. Most
often, it is looked for in the context of examinations following complaints of chronic pain in the musculoskeletal system (pain persistent for at least three months of the past 12 months). The largest replicated cross-sectional studies with identical questions aimed at researching the prevalence of chronic pain in musculoskeletal system are the studies conducted in 19951997 (n = 92,936) and 2006-2008 (n = 94,194) in Norway, which enlisted adults aged 20 and over; these studies revealed that through the 11 years, the incidence of such diseases has grown significantly, with senior women (50 y.o. and older), smoking and overweight people facing a particular risk. Disorders of musculoskeletal system were spreading especially quickly among people 20-29 y.o. during those 11 years. The difference in incidence of such diseases as it grew through time was statistically significant for both genders; behind this growth was hypodynamia associated with extensive use of computers and mobile phones [10]. The data from this study coincide with the results we obtained from the Mokshino rural outpatient clinic in 2016.
In the Republic of Belarus, the prevalence of dorsopathy was 8,008.5 ± 4,804.6 cases per 100,000 people (depending on the region) in 2001 [11]. Even with the maximum registered in Belarus, which is 12,813.1 cases per 100,000 people, is 1.7 times smaller than the incidence according to the Mokshino rural outpatient clinic records of 2011, which is 21,366.34 cases per 100,000 people.
Smoking Excess body weight
Hypercholesterolemia Alcohol abuse
Hypodynamia Occupational hazards
Drug abuse
0.01%
10.0% I Men
20.0% 30.0% ■ Women
40.0%
50.0%
60.0%
70.0%
80.0%
Fig. 3. Risk factors peculiar to 1203 rural residents, broken down gender-wise. 100% equals 540 men 663 women: HD — hypodynamia, HCL — hypercholesterolemia, AA — alcohol abuse, EBW — excess body weight
AH
Dorsopathy DGT (except UD) CHD
Chronic diseases of the urinary system Ulcer disease Chronic respiratory diseases ACA
Postinfarction cardiosclerosis Obesity Diabetes mellitus Oncologic diseases Other diseases
0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0% 35.0% 40.0% 45.0% 50.0% I Men Ш Women
Fig. 4. Noncommunicable chronic diseases diagnosed in 1203 rural residents. 100% equals 540 men 663 women: AH — arterial hypertension, DGT (except UD) — diseases of the gastrointestinal tract, CHD — coronary heart disease, ACA — acute cerebrovascular accident, PCS — postinfarction cardiosclerosis, DM — diabetes mellitus, CDUS — chronic diseases of the urinary system, CRD — chronic respiratory diseases, UD — ulcer disease
DGT (except UD) Obesity
Fig. 5. SRCC values for dorsopathy and other factors peculiar to the population group of rural residents studied: AH — arterial hypertension, HD — hypodynamia, AA — alcohol abuse, DGT (except UD) — diseases of the gastrointestinal tract, CHD — coronary heart disease, EBW — excess body weight, NNCD — numerous noncommunicable chronic diseases, ANCD — absence of noncommunicable chronic diseases, DM — diabetes mellitus, CDUS — chronic diseases of the urinary system, CRD — chronic respiratory diseases, UD — ulcer disease
An interesting study was conducted by American researchers: they aimed to determine the trabecular bone structure tensor [12]. The study proves there is an association between DMSCTs and hypodynamia; in the population group we studied, the SRCC between the two was 0.146. Citing the Wolff's law, the researchers have experimentally proven the need for moderate loads on musculoskeletal system as a prerequisite for correct development of the bone structure.
A recommended component of the secondary routines to prevent dorsopathies are special "schools" for people suffering back pain [13]. There, the patients should learn of the importance of moderate locomotor activity, minimization of NCDs RF in their lives [14, 15], treatment of comorbidities and physiotherapy. Such schools are open in many countries, e.g. in Australia [16].
CONCLUSIONS
Dorsopathy is the 2nd most common NCD found in the rural areas of the Tver region; the disease does not differentiate between types of occupations (heavy physical work and intellectual labor). The study shows that the number of
patients diagnosed with dorsopathies grows proportionally to the number of those undergoing routine checkups, even with the number of visits to the outpatient clinic decreasing; thus, routine checkups is an effective tool for primary and secondary prevention of dorsopathy.
Dorsopathy is strongly correlated to comorbidities (NCDs), age; less so — to hypodynamia and even less so — to the type of the patient's occupation. Significantly more women had diabetes mellitus and obesity as comorbidities of dorsopathy than men. Coronary heart disease was detected in patients with dorsopathy in equal proportions gender-wise.
General practitioners treating dorsopathy patients in a rural outpatient clinic are recommended to set up schools for patients suffering back pain, where they should learn of the importance of moderate locomotor activity, minimization of NCDs RF in their lives, treatment of comorbidities and physiotherapy. Curricula given to general practitioners should include specifics of observation and treatment of senior patients living in rural areas, as well as the effect sedentary lifestyle resulting from computerization of society has on the development of dorsopathy.
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