CC BY
3*
ALT'23 The 30th International Conference on Advanced Laser Technologies
B-I-32
Diffuse reflection based sapphire instruments for tissue characterization during ablation and resection
I.N. Dolganova1*, A.K. Zotov1, I.A. Shikunova1, K.I. Zaytsev2, V.N. Kurlov1
1- Osipyan Institute of Solid State Physics RAS, Chernogolovka, Russia 2- Prokhorov General Physics Institute, Moscow, Russia
*e-mail: in. dolganova@gmail. com
Combining remarkable properties, such as high hardness, mechanical strength, biocompatibility, chemical inertness, thermal resistance, high thermal conductivity at cryogenic temperatures, and high optical transparency in visible and near infrared ranges, sapphire can be applied for manufacturing of medical instruments for laser therapy and diagnosis, as well as for tissue resection and cryodestruction [1-4]. Different techniques for sapphire shaped crystal growth [5-7] provide significant expansion of opportunities of thus made instruments, since enable manufacturing of small crystals, with internal capillary channels, used for the accommodation of optical fibers, which can be connected with light sources and detectors. Therefore, such crystals allow performance of diffuse reflectance measurement, which opens perspectives for in situ diagnosis using compact sapphire medical instruments.
This work describes application of diffuse reflectance measurements made by sapphire scalpel and probes for cryosurgery and tissue condition monitoring. The scalpel combines analysis of fluorescence and diffuse reflectance intensities detected right on the scalpel blade [8]. This analysis allows for finding of tumorous tissue and estimate its margins with the resolution around 2 mm. Sapphire cryoprobe was developed enabling the modality of spatially resolved frequency-domain or stable-state diffuse reflectance measurements [9]. This probe can be applied for monitoring of tissue freezing depth during cryosurgery as well as for estimation of tissue optical properties that serves as a marker of cryo-necrosis. Another compact sapphire probe was tested for monitoring of circulatory disorder in muscle tissue. Using diffuse reflected intensity this probe can detect the alteration of the extinction coefficient of damaged tissue. This instrument can be further used for intraoperational noninvasive monitoring of tissue transplantation.
The problems of manufacturing of these instruments, theoretical aspects of estimation of tissue properties and particular examples of the applications of these instruments are discussed in the present work.
This work was supported by the Russian Science Foundation (RSF), research project # 19-79-10212.
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