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14
I. SURGERY
DAMAGE TO THE BILE DUCTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY. REVIEW
Doskhanov M.O.1, Baimakhanov B.B.1, Chormanov A.T.1,
Baimakhanov Zh.B.1, Kaniev Sh.A.1, Skakbayev A.C.1,
Izmet Zh.I.2, Sharmetova K.K.2, Ussen L.S.2, Madekhanova D.E.2
'JSC «A.N. Syzganov National Scientific Center for Surgery», Almaty, Kazakhstan 2NC JSC «S.D. Asfendiyarov National Medical University», Almaty, Kazakhstan
Abstract
This article provides a review of the literature on bile duct injuries after laparoscopic cholecystectomy. Laparascopy is considered the gold standard in the treatment of gallstone disease. This technique has a number of positive advantages: minimally invasiveness, quick rehabilitation, a shorter hospital stay, a good cosmetic effect, and a low lethal outcome. Along with these advantages, the number of complications also increased: damage to the bile ducts, hepatic vessels, bile leakage, formation of strictures, defects in drainage of the biliary tract and improper treatment of the cystic duct, insufficient drainage of the abdominal cavity.
Today, many aspects of surgical treatment and prevention of bile duct injuries remain controversial and are still considered relevant. The main reasons for this complication are: lack of experience of the surgeon, inattention, ignorance of the main options and possible anomalies of important anatomical structures in the area of the hepatic hilum and hepato-duodenal ligament, technical errors.
6т жолдарыньщ лапароскопияльщ холицистэктомиядан кешнп закымдалуы. Эдебиет шолуы
МРНТИ 76.29.39
https://doi.org/10.35805/BSK2021III017
DoskhanovM.O.
orcid.org/0000-0002-8578-8567
Baimakhanov B.B.
orcid.org/0000-0002-9839-6853
Chormanov A.T.
orcid.org/0000-0003-3513-1935
Baimakhanov Zh.B.
orcid.org/0000-0003-1887-7866
Kaniev Sh.A.
orcid.org/0000-0002-1288-0987
Skakbayev A.C.
orcid.org/0000-0003-0372-068X
Izmet Zh.I.
orcid.org/0000-0002-3132-3924 Ussen L.S.
orcid.org/0000-0002-5113-7926
Madekhanova D.E.
orcid.org/0000-0002-4328-861X
Corresponding author: Izmet Zh. I. - 7th year intern physician, NC JSC "S.D. Asfendiyarov National Medical University", Almaty, Kazakhstan
E-mail: jansila_96@mail.ru
Conflict of interest
The authors declare that they have no conflicts of interest
Keywords
iatrogenic trauma to the bile ducts, damage to the bile ducts, laparo-scopic cholcystectomy
Досханов М.О.1, Баймаханов Б.Б.1, Чорманов А.Т.1, Баймаханов Ж.Б.1, Каниев Ш.А.1, Скакбаев А.С.1, Исмет Ж.И.2, Шарметова К.К.2, Усен Л.С.2, Мадеханова Д.Е.2
1«А.Н. Сыз?анов атында?ы Улттык, ?ылыми хирургия орталь™» АК, Алматы к,., Казахстан 2«С.Ж. Асфендияров атында?ы Улттык, медицина университетi» Ке АК, Алматы к., Казакстан
Ацдатпа
Осы макалада вт жолдарынын лапароскопиялык, холицистэктомиядан кей1нп закымдалуы туралы эдебиетке шолу усынылЕан. Лапараскопия втжолдарында тас байланатын ауру турлерн емдеудеп ен непзп стандарт болып табылады. Бул эдЫн б1ркатар артыкшылыктары бар: инвазившкт1н аз мвлшерде болуы, тез калпына келу, ауру-ханада аз €ана уакыт жату, косметикалык эсер1 жаксы, вл1м жаЕдайынын вте аз кездесу1. Осы артыкшылыктармен катар аскынулардын саны да вст1: втжолдарынын,бауыр тамырларынын закымдануы, втжумысынын нашарлауы, вт жолдарынын тарылуы, вт жолдарын айдаудагы акаулар жэне вт кабы айналымын дурыс вндемеу, ¡ш куысын xeTKrniKrn турде айдап шыЕару.
Бупнп танда хирургиялык емдеуд1н квптеген аспектшер1 жэне вт жолдары жаракаттарынын алдын алу бупнп танга дей1н даулы мэселе болып келед1. Осы аскынулардын непзп себептер1: хирургтын тэж1рибес1нщ жеткш1кс1з болуы, укыпсыздык, бауыр какпалары мен бауыр-дуоденальды байлам аймаЕындаЕы манызды анатомиялык тузшмдерд/н непзп нускалары мен мумкн болатын ауыткуларын блмеу, техникалык кател1ктер.
Хат алысатын автор: Исмет Ж.И. - 7 курс дэркер-интерн, «С.Ж. Асфендияров атындары Улттык медицина университет» Ке АК,, Алматы к., Казакстан.
E-mail: jansila_96@mail.ru
Мудделер кактыгысы
Авторлар мудделер кактырысынын жокгыгын мeлiмдейдi
Туйш сездер
вт жолдарыныц ятрогенД жаракаты, вт жолдарыньщ закымдануы, лапароскопиялык холицистэктомия
Повреждение желчных протоков после лапароскопической холицистэктомии. Обзор литературы
Автор для корреспонденции: ИсметЖансила - врач-интерн 7 курса, НАО «Национальный медицинский университет имени С.Д. Асфендиярова», г. Алматы, Казахстан. E-mail: jansila_96@mail.ru
Конфликт интересов
Авторы заявляют об отсутствии конфликта интересов
Ключевые с лова
ятрогенная травма желчевыводящих протоков, повреждение желчевыводящих протоков, лапароскопическая холицистэктомия
Досханов М.О.1, Баймаханов Б.Б.1, Чорманов А.Т.1, Баймаханов Ж.Б.1, Каниев Ш.А.1, Скакбаев А.С.1, Исмет Ж.И.2, Шарметова К.К.2, Усен Л.С.2, Мадеханова Д.Е.2
1АО «Национальный научный центр хирургии им. А.Н. Сызганова», г. Алматы, Казахстан 2НАО «Национальный медицинский университет им. С.Д. Асфендиярова», г. Алматы, Казахстан
Аннотация
В данной статье представлен обзор литературы о повреждениях желчных протоков после лапароскопической холицистэктомии. Лапараскопия считается золотым стандартом при лечении желчнокаменной болезни. Данная методика имеет ряд положительных преимуществ: малоинвазивность, быстрая реабилитация, более короткий срок пребывания в стационаре, хороший косметический эффект, низкий летальный исход. Вместе с данными преимуществами возросло и число осложнений: повреждение желчных протоков,печеночных сосудов, желчеистечение, образование стриктур, дефекты дренирования желчных путей и неправильная обработка пузырного протока, недостаточное дренирование брюшной полости.
На сегодняшний день многие аспекты хирургического лечения и профилактика травм желчных протоков остаются спорными и по сей день считается актуальным. Основные причины данного осложнения: отсутствие опыта хирурга, невнимательность, незнание основных вариантов и возможных аномалий важных анатомических образований в зоне ворот печени и печеночно-дуоденальной связки, технические ошибки.
The urgency of the problem
Gallstones constitute a significant health problem in developed societies, affecting 10% to 15% of the adult population [1]. With an increase in the incidence of cholelithiasis, the number of surgical interventions on the gallbladder and bile ducts is increasing everywhere. The frequency of damage to the bile ducts during open cholecystectomy remains stable and amounts to 0.05-0.2% [2]. The widespread use of laparoscopic interventions contributed to an increase in iatrogenic injuries by 2-10 times to the level of 0.08-2.7 (Table 1) [3]. Also, the results of surgical treatment of injuries of the bile ducts indicate a high frequency of complications (48.7%), mortality (13-25%) and unsatisfactory long-term results (20-30%) [4]. Scarring of anastomoses reaches 8.4-28.3% [5]. latrogenic injury of the biliary tract have increased in incidence in the first decade with the introduction of laparoscopic cholecystectomy. Athough a number of factors have been identified with a high risk of injury (and number of technical steps have been emphasized to avoid these injury, the incidence of the bile duct injury has reached at least double the rate observed with open cholecystectomy [6]. The aim of this work is to identify and assess the significance and degree of iatrogenic and biliary complications during laparoscopic cholecystecto-my on the basis of the literature data, as well as to pay attention to the factors that increase the likelihood of complications and techniques to avoid these complications.
Material and methods
The article was analyzed from 2015 to 2020 in electronic databases (Cochrane, PubMed) of evidence-based medicine. 138 articles were found. The analysis of the condition of 815 patients (age from 21-70) was carried out. The average age is 46.32 ± 4.64 years. The disease was detected more often in women than in men [7]. According to autopsy data, the detection of stones in the gallbladder is 20-25% [8, 9].
Risk factors for bile duct injury after laparoscopic cholecystectomy
In the works of authors Fedorov, R. Martin and R. Rossi have identified several groups of risk factors for complications during LCE as dangerous anatomy (various structures of the extrahepatic bile ducts, arteries and the presence of pronounced fatty tissue in the gates of the liver and hepato-duodenal ligament), dangerous pathological findings (acute cholecystitis, stone in Hartmann's pocket, short cystic duct, thickened walls of the gallbladder, dilated common bile duct, chronic scars of the gallbladder, bleeding into Calot triangles, adhesions in the abdominal cavity), dangerous surgery (mobilization of the gallbladder body from the liver, maximum mobilization Kahlo's triangle closer to the wall of the gallbladder, intraoperative cholangiography or laproscopic ultrasound, mobilization of the gallbladder from the bottom, performing subtotal cholecys-tectomy with pronounced cicatricial process and if it is not possible to mobilize it, conversion) [23,24].
Authors, educational institutions, departments The Title of an article Researh year Number of patients Incidence rate
Institute of Gastroenterology of the Academy of Medical Sciences of Ukraine, Dnipetrovsk National University [10]. Iatrogenic complications of laparoscopic cholecystectomy 1993-2003 3864-LCh 46- IBDD 1,19%
Khalidov O.Kh., Gudkov A.N., Dzhaddzhiev A.B., Kartsev A.G., Fomin V.S., Dmitrienko G.P. [7]. Extrahepatic bile duct injury during laparoscopic cholecystectomy 2007-2017 1787- LCh 8- IBDD 0,45%
Filistovich V., Turchina S., Maslennikov S., Filistovich A. [11]. Severe damage to the external bile ducts in laparoscopic cholecystectomy 2004-2008 21- IBDD
Kubachev K.G., Fokin A.M. [12]. Iatrogenic damage to the extrahepatic bile ducts in laparoscopic cholecystectomy 2001-2016 113- IBDD 39,8%
N. A. Maistrenko, P. N. Romashchenko, A. S. Pryadko, A. K. Aliev [4]. Substantiation of surgical tactics for iatrogenic injuries of the bile ducts 1988-2005 254- IBDD
Takeyuki Misawa, Ryota Saito, Hiroaki Shiba, Kyonsu Son, Yasuro Futagawa, Takuya Nojiri, Kumiko Kitajima, Tadashi Uwagawa, Yuichi Ishida, Yuji Ishii and Katsuhiko Yanaga [13]. Analysis of bile duct injuries (Stewart-Way classification) during laparoscopic cholecystectomy 1990-2005 5750- LCh 34- IBDD 0,59%
Andrea Frilling, Jun Li, Frank Weber, Nils Roman FruEhauf, Jennifer Engel, Susanne Beckebaum, Andreas Paul, Thomas ZoEpf, Massimo Malago, Christoph Erich Broelsch[14]. Major Bile Duct Injuries After Laparoscopic Cholecystectomy: A Tertiary Center Experience 1998-2003 40- IBDD
J. Li, A. Frilling, S. Nadalin, A. Paul, M. Malago and C. E. Broelsch [15]. Management of concomitant hepatic artery injury in patients with iatrogenic major bile duct injury after laparoscopic cholecystectomy 1998-2005 40-IBDD 17 %
S. C. Schmidt J. M. Langrehr U. Settmacher P. Neuhaus[16]. Chirurgische therapie von gallengangverletzungen nach laparoskopischer cholezystektomie . welchen einfluss auf den langzeitverlauf hat die gleichzeitige verletzung der arteria hepatica dextra ? 1990-2002 54- BDD
A Paczynski , T Koziarski, E Stanowski, J Krupa [17]. Damage to extrahepatic bile ducts during laparoscopic cholecystectomy--own experience 1991-2000 6873- LCh 9- IBDD
Mohammad Ibrahim Khalil, Haridas Saha, Azmal Kader Chowdhury, Imarat Hossain[18]. Bile duct injuries following laparoscopic cholecystectomy 2013-2015 336- LCh 2- BDD 0,6%
V.F. Kulikovsky, A.L. Yarosh, A. Karpachev, Coman A.V. Soloshenko, S.B. Nikolaev, E.P. Bitenskaya, N.A. Linkov [19]. Bile leakage after cholecystectomy. Experience with minimally invasive treatment methods 2010-2016 5038- LCh 31- BDD 0,6%
Тable 1.
Literature data
G E Chinnery , JEJ Krige , PC Bornman , M M Bernon , S Al - Harethi , S Hofmeyr , M A Banderker , S Burmeister , S R Thomson [20]. Endoscopic management of bile leaks after laparoscopic cholecystectomy 1991-2011 113- BDD
J.M. Kurbanov [21]. Experience in surgical treatment of complications of laparoscopic colicystectomy 2003-2012 421- LCh 3- BDD 0,7%
Sitnikov V.A., Styazhkina S.N., Ibragimova D.R., Kasimova [22] latrogeny as a cause of postcholicystectomy syndrome 1978-2018 87-BDD
LCh*- laparoscopic cholecystectomy IBDD*- iatrogenic bile duct damage BDD*- bile duct damage
The technical reasons contributing to iatrogenic injuries during cholecystectomy include: Features of the anatomy of the extrahepatic biliary tract; factors complicating the performance of cholecystectomy; violation of the technique of performing operations on the biliary tract. In the anatomy of the biliary tract, there is a wide variety of anatomical options. A practical surgeon is obliged to remember these options, to be able to understand them in a timely manner during the operation and to avoid possible complications. On average, in every fifth to sixth operated patient, the surgeon may encounter difficulties in identifying the place of fusion of the cystic and hepatic ducts (VN Chernyshev, 2001). And this is one of the reasons for the high frequency of iatrogenic injuries of the bile ducts. [22]
Also the risk factors for damage to the biliary tract include old age (increases the risk of damage by 2.5 times), female sex (increases the risk by 26%), late hospitalization of patients [22].
The Laparoscopic damage to the bile ducts has rather large consequences. In recent years, the introduction of new technologies has again made the issue of compliance with the principles of safe surgery and prevention of complications urgent.
Prevention of bile duct injury during and after laparoscopic cholecystectmy
The prevention of damage to the bile ducts is a complex of measures (techniques, diagnostic methods) carried out directly during the performance of laparoscopic cholecystectomy and aimed at preventing damage to the bile ducts. It is based on strict adherence to the principles of a safe technique for performing endoscopic interventions, the correct sequence of the stages of laparoscopic cholecystectomy, taking into account the peculiarities of anatomy and pathological changes, and an understanding of the mechanisms of complications [25].
The risk of complications dictates the need for a complex of preventive measures to prevent complications and optimize intraoperative processes. Safe laparoscopic cholecystectomy involves understanding anotomic landmarks, these include: Calot's triangle, Callo's lymph node, Rouvier's groove, umbilical fissure with the round ligament lying in it, the fourth segment of the liver, pericho-ledochial venous plexuses [26].
The main requirement when performing laparo-scopic cholecystectomy is a thorough preparation of tissues in the area of the Calot triangle and the lower third of the gallbladder bed, as well as conversion or "change of hand" after "idle time" when manipulating the gallbladder neck for more than 30-40 minutes. An important factor in the analysis of the technique and interpretation of the intraoperative situation is the video recording of the entire operation with the subsequent discord of errors and possible shortcomings. If the listed requirements are met, the risk of postoperative complications will be minimized [7].
Intraoperative ultrasound is a screening method for laparoscopic operations, playing the role of the surgeon's "hand", and allows to reduce the number of intraoperative complications. The use of IOUS is advisable in cases of an unclear topographic picture, with various anatomical variants of the bile ducts and great vessels The high resolution of IOUS in determining structures both in hepaticoholedo-chus and outside it proves the effectiveness of this diagnostic method, and speaks of the advisability of using echography during laparoscopic and traditional operations [27].
Fluorescence cholangiography significantly reduces the time to reach the "safety critical" in LCE and avoids damage to the bile ducts compared to standard laparoscopy. PC can be successfully used to assess the patency of the IVS in certain situations (suspicion of transient choledocholithiasis, signs of parenchymal jaundice in combination with cholelithiasis, for example, jaundice in liver cirrhosis or chronic hepatitis) [28].
The classification of bile duct injury after laparoscopic cholecystectomy
Currently, there are many classifications of damage to the bile ducts. Abroad, the Bismuth classification (Fig. 1) is especially popular, which classifies damage to the extrahepatic ducts according to the level of their damage [26].
However, most of the developed classifications do not determine the choice of surgery, which significantly reduces their value for a practical surgeon. The classification developed by E.I. Halperin, according to the type of damage, according to the author himself, makes it possible to fill this gap [26].
In 1986 E.I. Galperin et al. Proposed a classification for determining the type of damage and narrowing of the bile ducts, which is very close to the classifications of N. Bismuth and S. Strasberg. V.N. Chernyshev and V.E. Romanov (2001) combined the classification of N. Bismuth and S. Strasberg into a single one (Fig. 1), which they used in their studies [29].
Type I - stricture of hepaticoholedochus with the presence of its unaffected area below the confluence of the hepatic ducts more than 2 cm long;
Type II - stricture of hepaticoholedochus with a free area of the common hepatic duct less than 2 cm long;
Type III - complete cicatricial damage to the common hepatic duct with a free zone of confluence of the lobar hepatic ducts;
V type - complete cicatricial obliteration of the common hepatic duct with the transition to the lo-bar hepatic ducts;
Type V - high or low cicatricial stricture of the hepatic cholecule with atypical anatomy of the biliary tract.
In 2002 E.I. Galperin published a refined classification of postoperative cicatricial strictures of the hepatic ducts.
The Stewart-Way classification included both complex lesions of the biliary tract and vascular lesions. Based on the Stewart-Way classification (Fig. 2), bile duct trauma is divided into four classes:
Class I injuries occur when the common hepatic duct is mistaken for the cystic duct, but the error is recognized before the common hepatic duct is divided.
Class II injuries involve damage to the common hepatic duct due to clamps or cauterization used too close to the duct. This often happens when vision is limited due to inflammation or bleeding.
Class III injury, the most common type, occurs when the common bile duct is mistaken for the cystic duct. The common duct is transected and the variable portion, including the junction of the cystic and common ducts, is excised or removed.
Class IV injuries involve damage to the right hepatic duct, either because this structure is mistaken for the cystic duct or because it is damaged during dissection [13].
The intraoperative signs of damage to the bile ducts can be: the appearance of bile in the operating field, with an unclear source of bile leakage, the appearance of additional tubular structures in the area of the Calot triangle, expansion of the alleged cystic duct stump during the operation. Any suspicion of injury requires intraoperative cholangiography or conversion. Each removed (gallbladder) should be carefully examined for additional tubular structures before surgery is completed [30].
Bile leakage can sometimes be associated with unrepaired biliary hypertension caused by choledo-cholithiasis, stenosis of the large duodenal papilla.
Type Characteristic of strictures
+2 Medium and low - common hepatic duct (AKI) more than 2 cm
+1 High - TPI is 1 - 2 cm
0 Bifurcation - OPP is 0-1 cm
-1 Transbifurcation - the connection of the lobar hepatic ducts (PP) is preserved
-2 Ductal - lobe PP are disjointed
-3 Segmental - lobar RA (more often right) cicatricial changes, preserved segmental RA
Figure 1.
Anatomical types or classification
Table 2.
Classification of postoperative cicatricial strictures of the bile ducts (E.I. Galperin, 2002)
Figure 2.
Diagnosis of injuries of the bile ducts after laparo-scopic cholecystectomy during surgery
Less than 50% of duct injuries are detected intraoperative^, usually due to bile leakage [31].
Intraoperative recognition usually requires immediate surgical intervention as this gives the best results; however, during surgery, <25-30% of bile duct lesions are recognized, and not all surgeons perform intraoperative cholangiography. If the surgeon is inexperienced, an intra-abdominal drain should be placed and the patient immediately transferred to a large hepatobiliary center [32].
Intraoperative ultrasonography (IUS) visualizes the transverse andthe longitudinal planes of not only the biliary structures, but also the portal vein, as well as the hepatic arteries by introducing a linear ultrasound probe [33].
If in open cholecystectomy the main mechanisms of trauma are transection, excision and liga-tion, then in laparoscopic cholecystectomy clipping and diathermic necrosis of the bile duct wall are added to them [34,35]. Currently, monopolar elec-trocoagulation remains the main type of dissection in laparoscopic cholecystectomy [36].
Surgical tactics for detecting damage to the bile duct during surgery
In case of intraoperative detection of damage to the bile ducts, it is necessary to immediately perform corrective surgery or, if reconstructive surgery is impossible, external drainage is performed [24].
As a rule, with small marginal lesions, plastic closure of the duct at the site of injury with interrupted sutures with absorbable atraumatic sutures (vicryl, polysorb 4-0) is sufficient in combination with external drainage of the bile ducts through the cystic duct stump or, most often, using a T-shaped drainage. In the case of a dislocation of the clip and the failure of the cystic duct stump in the absence of hypertension in the biliary system and obstructions to the main bile outflow, sanitation of the abdominal cavity and reclipping can be performed with relanarosonia. With complete confidence in
parietal or complete clipping of the bile duct without violating the integrity of its wall, relaparoscopy with the removal of the clip and external drainage of the biliary tract through the cystic duct cult is also advisable [25].
If a traumatic injury to the bile ducts is detected (during the transection or excision of a segment), 3 options for subsequent actions are possible: external drainage of the biliary system, performing a restorative (biliary-biliary anastomosis end-to-end, prosthetics of the defect) or reconstructive surgery (biliodihistic anastomosis). Surgeons with little experience, in our opinion, should confine themselves to external drainage of the biliary tract, and drain or bandage the distal common bile duct to avoid leakage of pancreatic juice into the abdominal cavity. Subsequently, the patient should be transferred to a specialized department to perform reconstructive surgery [31].
In case of damage to the bile ducts, in many cases, the operation of choice is the imposition of a biliodihistic anastomosis according to Roux, he-paticojejunostomy with transhepatic frame drainage according to Pradery-Smith or Goetze-Saypol-Ku-rian, and hepaticojejunostomy according to Nerr-Couinaud. The frequency of good and satisfactory results in the treatment of patients with biliary tract injury when using biliodigistive anastomoses ranges from 46 to 94%. Restoration of the common bile duct on a T-shaped drainage of the "end-to-end" type in 50-60% of cases leads to unsatisfactory results [37].
For restoration or reconstruction of damaged bile ducts, the optimal period should be considered 3-5 days, surgical reconstruction in the volume of the Roux loop is accompanied by success in more than 90% of observations within the next 5 years after surgery [38].
With an average level of damage, the incision is extended in the direction of the left lobar duct. In cases of high lesions for access to the left lobar
Injury (1) Localization (L) Experience surgeon Recommended operation
Intersection, Intra- and extrahepatic XC(SS) Reconstructive
Excision Extrahepatic X(S) Drainage of the main bile ducts as the first stage of the operation *
Partial (edge) thermal, clipping X (S) Reconstructive, usually on a frame drainage
Intrahepatic XC(SS) Reconstructive, usually on a frame drainage
X (S) Drainage connection to the damage site *
Table 3.
Classification of "fresh"
injuries of the main bile
ducts (PLC-ILS), which
determines the choice of
surgery
(E.I. Galperin,
A.Yu. Chevokin, 2010)
duct, it is necessary to bring down and dissect the portal plate according to the Hepp-Couinaud technique [25].
In the surgical treatment of high lesions of he-paticoholedochus (from "0" to "-3") with the involvement of confluence, planar resection of the parenchyma of the hepatic hilum is performed, the unification of the lobar ducts into one trunk, followed by the formation of a bihepaticojejunostomy [12].
Based on the analysis of the experience of surgical treatment of patients with iatrogenic injuries of the biliary tract, it was shown that hepaticoje-junostomy was resorted to with high injuries and strictures of the bile ducts and the length of the duct stump at least 30 mm, with high injuries and the residual length of the extrahepatic bile ducts less than 10 mm used hepaticojejunostomy with transhepatic frame drainage according to Pradery-Smith or Goetze-Saupol-Kurian, which allowed the authors to achieve positive results in more than 80% of cases [39].
In case of biliary tract injuries of type IY according to Bismuth, it is possible to use two variants of the operation: the first is the formation of anastomosis separately with each of the lobar ducts, the second is a single anastomosis with a fork formed by stitching the adjacent walls of the lobar ducts according to the method of Shalimov A [25].
In 2009 E.I. Galperin and A. Yu. Chevokin proposed the classification of ILS "fresh" lesions. In 2010, it was supplemented with the heading "Surgeon's Experience" - the classification of PLC - ILS [29].
Diagnosis of damage to the bile ducts in the postoperative period and surgical tactics
Postoperative diagnosis is based on the clinical picture (manifested in the form of three possible options: bile outflow syndromes, obstruction syndromes or a combination of obstruction and bile outflow), laboratory test results (serum biliru-bin level, transaminases, shift of the leukocyte formula to the left, etc.). non-invasive (ultrasound, CT, cholespintigraphy, fistulography through a safety drainage or drainage of the common bile duct) and invasive (retrograde cholecystopancreatography;
percutaneous transhepatic cholangiohepatography and laparoscopy) instrumental methods [31].
Symptoms will be nonspecific and may include fever, pain, and mild hyperbilirubinemia (2.5 mg / dL) due to biloma or biliary peritonitis. Bile leakage may be suspected if bile is produced by percutaneous abdominal drainage or abdominal drainage from cholecystectomy. In the case of injuries associated with occlusion of the common bile duct without intraperitoneal bile flow, the main symptoms will be jaundice with or without abdominal pain [40].
In severe early postoperative cases, patients present with sepsis due to cholangitis or fluid accumulation in the abdomen. If a bile leak is suspected, ultrasound and / or computed tomography of the abdomen will reveal peritoneal fluid, biloma, or abscess. In case of accumulation of perihepatic fluid, drainage can be applied percutaneously. Generally, broad-spectrum parenteral antibiotics are given against common biliary tract pathogens. When percutaneous drainage is applied and ongoing biliary drainage is observed, active bile flow is confirmed [40].
Damage to the bile ducts after laparoscopic cholecystectomy is recognized by the release of bile into the abdominal cavity, which causes peritonitis and creates a favorable environment for bacterial reproduction [26]
Bile leakage, jaundice, biliary peritonitis are the diagnostic triad of damage to the extrahepatic ducts in the postoperative period. Surgical tactics in this case are built after a complete diagnosis of the anotomic structure of the bile ducts, the level and nature of the damage [26].
Radiological examination determines the damage to the bile ducts and its severity, its length and severity, for planning therapeutic treatment. Abdominal ultrasound is the first diagnostic tool to detect any liver congestion, common bile duct dilatation, and any associated vascular lesions [41].
Computed tomography of the abdomen is the primary test that detects the possible presence of focal intra- or focal lesions, accumulation of perihepatic fluid, ascites, obstruction of the biliary tract with upstream dilation, or long-term consequences of prolonged bile stricture such as croupous atrophy of the liver or signs of secondary biliary cirrho-
sis. Computed tomography can also identify any associated vascular lesion, such as the right hepatic artery [42].
Magnetic resonance cholangiopancreatography (MRCP) is the gold standard for the complete morphological assessment of the biliary tract because it offers detailed information about the integrity of the biliary tract [43]. Magnetic resonance cholangiopancreatography can also be performed with a contrast medium (a gadolinium-based contrast medium, gadoxetic acid and its salt, gadoxetate disodium), and it is much more informative in bile leakage than conventional magnetic resonance cholangiopancreatography [44]. The use of contrast media during magnetic resonance cholangiopancreatography allows active bile leakage to be detected by direct contrast imaging, extravasation of material in the fluid collection in addition to demonstrating the anatomical location of the leak and the type of bile duct injury. In the same way, hepatobiliary scintigraphy can confirm the presence of an active bile duct with progressive accumulation of the radioactive tracer within the abdominal cavity, but this test is much less reliable [45].
If bile leakage occurs in the postoperative period, the tactics of treatment depend on the adequacy of the outflow of bile from the abdominal cavity and the cause of complications. If earlier, with bile leakage, many surgeons performed relaparotomy, in recent years, laparoscopic interventions have been performed, during which the source of bile leakage is eliminated (clipping of the bile ducts in the bed of the bladder or the cystic duct stump) or is limited to sanitation of the abdominal cavity and its additional drainage [31].
Reconstructive surgery of damaged bile ducts is performed no earlier than 2 months later. It is more difficult and more difficult to perform biligiodiges-tive anastomosis in patients with complete external biliary fistulas, especially with high confluence and resolution [46].
Damage to the aberrant gallbladder is one of the rarest type of iatrogenism in laparoscopic cholcystectomy, manifested by bile leakage of varying intensity. in most cases, these complications regress on their own, which is associated with the small diameter of the aberrant duct, which is quickly obliterated. Reoperations (suturing the stump of the duct or its restoration on a T-shaped drainage) are required only in cases of a long-term functioning bile fistula or the development of complications against the background of bile leakage [46].
Performing retrograde transpapillary stenting contributes to effective cessation of bile leakage and refusal to perform repeated surgical interven-
tions in case of failure of the cystic duct stump, in case of bile outflow from the gallbladder bed, as well as in case of marginal damage to the extrahe-patic bile ducts [47].
Liver resection for bile duct injuries after lap-aroscopic cholecystectomy
Liver resection is not required for isolated damage to the bile duct [48]. However, the presence of vascular damage worsens the clinical course of the patient, due to the development of complications such as liver necrosis and bile duct stricture [16,49,50]. Because the right hepatic artery runs close and parallel to the cystic duct, it is more vulnerable to injury [51,52] and can be easily ligated if the structures in the Calot triangle are not well defined [53]. Although occlusion of the right hepatic artery is usually well tolerated, as collateral arteries from the diaphragm and retroperitoneal space support the liver [16,54]. The development of intrahepatic abscess [18], ischemic necrosis of the right lobe of the liver [16], recurrent cholangitis and subsequent secondary biliary cirrhosis [16], as well as liver atrophy, require liver resection for successful treatment. The incidence of liver necrosis in patients with damage to the bile duct and arteries with or without abscess formation reaches 75%. Nearly half of these patients who underwent bilioenteric anastomosis to treat a damaged bile duct developed postoperative biliary leakage due to primary he-paticojejunostomy [55] or late ischemic peripheral bile duct stenosis [55]. Thus, patients with confirmed damage to the bile duct should be examined for concomitant hepatic artery damage, and if present, comprehensive treatment should be undertaken immediately [56]. Combined damage to the bile ducts and hepatic artery requires different types of liver resections to treat mainly secondary biliary cirrhosis [57].
Morbidity and mortality in bile duct injuries after laparoscopic cholecystectomy
In the postoperative period after Y-shaped he-paticojejunostomy according to Ruu, 80% of patients developed cholangitis and 20% jaundice. All were re-operated. The average follow-up period after surgery was 49 + 40 months. In the postoperative period, 16% of patients underwent another 2-3 surgical interventions, with a good result achieved in 89% of those operated [58].
The quality of life after the formation of a biliary anastomosis for iatrogenic damage to the biliary tract received disappointing results - their quality of life was significantly reduced (p <0.05). With complete intersection of the duct, in contrast to the marginal wound, poor long-term results of reconstruc-
tive operations were explained by impaired blood supply to the biliary tract and the development of ischemia, which apparently contributed to their postoperative scarring. The indicators of the quality of life of patients with biliodigestive anastomosis superimposed on the duodenum were significantly reduced. After the formation of the Roux-ened bi-hepaticojejunoanastomosis with the hepatic tran-shepatic drainage, the patients showed decreased indicators of physical functioning, pain intensity, vital activity, general health and role functioning, due to the general physical condition. It is noteworthy that low indicators of the quality of life of the operated patients were characteristic of this group during the period of hepatic transhepatic drainage functioning. After hepaticojejunostomy according to Brown with a "plug" according to Shalimov, the indicators of role functioning and vital activity were reduced on hepatic transhepatic drainage [59].
Combined injuries of the bile ducts and blood vessels account for more than half of the unsatisfactory treatment results and mortality. When the operation is performed by a surgeon who does not have sufficient experience in hepatobiliary surgery, mortality rises to 30%. At the same time, if the operation is performed in a specialized center, the successful result is recorded in 90% [60,61,62,63]. The effectiveness of the radiological approach with
References
1. Laura M. Stinton and Eldon A. Shaffer Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer Gut and Liver, Vol. 6, No. 2, April 2012, pp. 172-187 doi:10.5009/gnl.2012.6.2.172
2. Starkov Yu.G., Vyborny M.I., Dzhantukhanova S.V., Andreitseva OI, Khon E.I. Endoscopic treatment of surgical trauma of the right lobar bile duct. Experimental and clinical gastroenterology. 2018; 152 (4): 107-110.
3. Borisov AE Guidelines for surgery of the liver and biliary tract. In two volumes), St. Petersburg SPb: Scythia, 2003.- 488 p.
4. Maistrenko N.A., Romashchenko P.N., Pryadko A.S., Aliev A.K. Substantiation of surgical tactics for iatrogenic injuries of the bile ducts. ISSUES OF GENERAL AND PRIVATE SURGERY "Bulletin of Surgery" 2015 UDC 616.361-089-06.616.361-001-08.
5. Nalbandyan A.G., Anishchenko V.V., Kovgan Y.M., "Methods of percutaneous transhepatic and transdrainage stenting of post-traumatic strictures of the bile ducts." № 1 - 2015 14.00.00 medical sciences UDC 616.367-001-089.
6. Svab J., Peskova M., Krska Z., Gurlich R., Kasalicky M. Prevention,diagnosis and surgical treatment of injuries of the biliary trct during laparoscopic cholecystectomy. Treatment of papilla injures caused by invasive endoscopy. Part 2. Surgical treatment of biliary tract injures. Rozhledy v chirurgii: mesicnik Ceskoslovenske chirur-giske spolecnosti. 2005 April 84(4):182-90.
transhepatic stenting of the damaged bile duct is estimated at 40-85% [64].
After repeated operations in the long-term period, cicatricial strictures on the biliary tract develop in 20-30% of cases, and biliary cirrhosis and portal hypertension develop against the background of chronic cholangitis - complications leading to disability [65,66].
The immediate and long-term results of treatment of injuries of the main bile ducts (IVS) are unsatisfactory: the immediate mortality rate is 8-10%, and in the later stages 13-17% [67,68].
Conclusion
The analysis of the literature showed that the prevention, timely diagnosis and treatment of damage to the bile ducts during and after laparo-scopic cholecystectomy remains an unresolved issue. Timely diagnosis of damage to the bile ducts and surgical tactics at different stages give good long-term results. In the absence of experience in reconstructive operations, the intervention must be limited to external drainage of the ducts with the subsequent referral of the patient to a specialized hospital. Reconstructive and restorative surgeries for gallbladder injuries should be performed using precision techniques with the presence of atraumatic absorbable suture materials.
7. Khalidov O.Kh., Gudkov A.N., Dzhaddzhiev A.B., Kartsev A.G., Fomin V.S., Dmitrienko G.P. "Damage to the extrahepatic bile ducts in laparoscopic cholecystectomy." Annals of Surgical Hepatol-ogy, 2017, Volume 22 No. 4 DOI: 10.16931 / 19955464.2017446-52
8. Galperin E.I., Vetsheva P.S. - M., 2009. Guidelines for surgery of the biliary tract-569 p.
9. Ivashchenko A. V. "Some questions of the epidemiology of gallstone disease in young patients in the light of 20 years of experience in laparoscopic surgery" / A. V. Ivaschenko // Klin. surgery. - 2012-№ 10 UDK 616.366-003.7-053.81:616.381-072.1089-036.22.
10. Institute of Gastroenterology, AMS of Ukraine, Dni-petrovsk National University. "Iatrogenic complications of laparoscopic cholecystectomy". https:// medic.ua/bolezn/yatrogenny-e-oslozhneniya-lapa-roskopiche/
11. Filistovich V., Turchina S., Maslennikov S., Filistovich A. "Severe injuries of the external bile ducts during laparoscopic cholecystectomy." http://www.sibmed-port.ru/article/1090-tjazhelie-povrezhdenija-naru-zhnih-zhelchnih-protokov-pri-laparoskopicheskoy-holetsistektomii/
12. Kubachev K.G., Fokin A.M. "Iatrogenic damage to the extrahepatic bile ducts in laparoscopic cholecystectomy"Takeyuki Misawa, Ryota Saito, Hi-roaki Shiba, Kyonsu Son, Yasuro Futagawa, Takuya
Nojiri, Kumiko Kitajima, Tadashi Uwagawa, Yuichi Ishida, Yuji Ishii, and Katsuhiko Yanaga. «Analysis of bile duct injuries (Stewart-Way classification) during laparoscopic cholecystectomy» T. 22, № 3, 2017 UDK 616,366-089.87.
13. Takeyuki Misawa, Ryota Saito, Hiroaki Shiba, Kyo-nsu Son, Yasuro Futagawa, Takuya Nojiri, Kumiko Kitajima, Tadashi Uwagawa, Yuichi Ishida, Yuji Ishii, and Katsuhiko Yanaga. «Analysis of bile duct injuries (Stewart-Way classification) during laparoscopic cholecystectomy^ Journal of Hepato-Biliary-Pancre-atic Surgery, 13(5), 427-434. doi:10.1007/s00534-006-1099-z.
14. Andrea Frilling, Jun Li, Frank Weber, Nils Roman FruEhauf, Jennifer Engel, Susanne Beckebaum, Andreas Paul, Thomas ZoEpf, Massimo Malago, Christoph Erich Broelsch. «Major Bile Duct Injuries After Laparoscopic Cholecystectomy: A Tertiary Center Experience» Journal of Gastrointestinal Surgery volume 8, pages 679-685 (2004). DOIhttps://doi. org/10.1016/j.gassur.2004.04.005.
15. Li J., Frilling A., Nadalin S., Paul A., Malago M. and Broelsch C. E. «Management of concomitant hepatic artery injury in patients with iatrogenic major bile duct injury after laparoscopic cholecystectomy» British Journal of Surgery, 95(4), 460-465. doi:10.1002/ bjs.6022
16. Schmidt S.C., Langrehr J.M., Settmacher U., Neuhaus P. «Chirurgische Therapie von Gallengangver-letzungen nach laparoskopischer Cholezystektomie. Welchen Einfluss auf den Langzeitverlauf hat die gleichzeitige Verletzung der Arteria hepatica dextra?» ZentralblChir2004;129(6): 487-492 DOI: 10.1055/s-2004-832413
17. A Paczynski , T Koziarski, E Stanowski, J Krupa «Damage to extrahepatic bile ducts during laparo-scopic cholecystectomy--own experience». Medical science monitor 2001 May;7 Suppl 1:102-4.
18. Mohammad Ibrahim Khalil , Haridas Saha , Azmal Kader Chowdhury , Imarat Hossain «Bile Duct Injuries Following Laparoscopic Cholecystectomy» Journal of Science Foundation 2017;15(1):14-19 DOI: https:// doi.org/10.3329/jsf.v15i1.34778
19. Kulikovsky F., Yarosh A.L., Karpachev A.A., Coman Soloshenko A.V., Nikolaev S.B., Bitenskaya E.P., Linkov N.A., Av. "Bile leakage after cholecystectomy. Experience of using minimally invasive methods of treatment" Surgery. Journal them. N.I. Pirogov. 2018; (4): 36-40 DOI 10.17116 / hirurgia2018436-40
20. Chinnery G.E., Krige JEJ, Bornman P.C., Bernon M.M., Harethi S.Al., Hofmeyr S., Banderker M.A., Burmeister S., Thomson S.R. «Endoscopic management of bile leaks after laparoscopic cholecystec-tomy» » South African journal of surgery. 2013 Oct 25;51(4):116-21. DOI: 10.7196/sajs.1829
21. Dzh.M. Kurbanov "Experience of surgical treatment of complications of laparoscopic colicystectomy" SCIENTIFIC MEDICAL JOURNAL "VESTNIK AVI-CENNY" OF THE TAJIK STATE MEDICAL UNIVERSITY NAMED AFTER ABUALI IBNI SINO No. 3, JULY-SEPTEMBER 2013
22. Sitnikov V.A., Styazhkina S.N., Ibragimova D.R., Kasimova N.R. "Iatrogeny as a cause of postcho-licystectomy syndrome. Perm Medical Journal 2020 Volume XXXVII No. 2 DOI: 10.17816 / pmj37241-47
23. Martin R. F. Bile duct injuries. Spectrum, mechanisms of injury, and their prevention / R. F. Martin, R. L. Rossi // Surg Clin North Am. - 1994 Aug. - Vol. 74, N 4. - P. 781-803
24. Fedorov I.V., Slavin L.E., Chugunov A.N. Damage to the bile ducts during laparoscopic cholecystectomy. M., 2003.79 p.
25. Yu.V.Ivanov, D.V. Sazonov, D.P. Lebedev, O.E. Nechaeva Prevention and treatment of intraoperative damage to the extrahepatic bile ducts during laparoscopic cholecystectomy. Original Research Clinical Practice No. 4, 2011.
26. Almasud R., Osmanova A.O., Mikhailichenko V.Yu. Iatrogenic complications during laparoscopic cholecystectomy and their prevention .Scientific Review. Medical sciences. - 2020. - No. 4 - P. 7-11 doi: 10/17513 / srms.1120
27. Kurpilyansky, A.V. Intraoperative study of extrahepatic bile ducts, 2005 VAK RF 14.00.27
28. Malinovsky A.V., Mayorenko M.N., Chernov N.N. The first experience of using fluorescent cholangiography to assess the patency of extrahepatic bile ducts. Hirurgiya of Ukraine.- 2018.- No. 1.- P. 40-45. UDC 616.367-073.8: 681.3
29. Belokonev V.I. Surgical treatment of patients with injuries and strictures of the bile ducts., 22-24 p.
30. PA Askarov "Fresh" damage to the extrahepatic bile ducts. Samarkand State Medical Institute, Republic of Uzbekistan. ISSN 1681-2778. Spital surgery. L. Ya. Kovalchuk's magazine. 2018. No. 1 DOI 10.11603 / 2414-4533.2018.1.8854
31. N. A. Mizurov, A.G. Derbenev, V.V. Voronchikhin. Errors and Complications During Biliary Surgery 2010, "Health care of Chuvashia" 2010,1 issue
32. Seeras K, Qasawa RN, Kashyap S, et al. Bile Duct Repair. [Updated 2021 May 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih. gov/books/NBK525989/
33. Floyd W. vande Graaf*, Ina Zaimi, Laurents P. S. Stassen, Johan F. Lange 2018 Safe laparoscopic cholecystectomy: A systematic review of bile duct injury prevention International journak of sutgery 2018 Dec;60:164-172. doi: 10.1016/j.ijsu.2018.11.006. Epub 2018 Nov 12.
34. Romaschenko P.N., Maistrenko N.A., Pryadko A.S., Aliev A.K. Bile duct trauma and a systemic approach to their elimination Annals of Surgical Hepatology, 2019, volume 24, No.1 D0I:10.16931/1995-5464.2019171-82
35. Nichitailo M.E., Skums A.V. Surgical treatment of injuries and strictures of the bile ducts after cholecystectomy. Almanac of the Institute of Surgery. A.V. Vishnevsky. 2008 3 (3), 71-76.
36. Maistrenko N.A., Romashchenko P.N., Aliev A.K., Sibi-rev S.A. Acute damage to the bile ducts bulletin of the russian military medical academy founders: military medical academy named after CM. Kirov, LLC "Eco-Vector", Ministry of Defense of the Russian Federation (St. Petersburg) ISSN: 1682-7392eISSN: 2687-1424.
37. Kurbanov D.M., Rasulov N.I., Ashurov A.S. Complications of laparoscopic cholecystectomy. Novosti Khirurgii. 2014 May-Jun; Vol 22 (3): 366-373.
38. Kurbanov J.M. "Clinic, diagnosis and surgical treatment of complications of laparoscopic cholecystectomy and methods of their prevention" UDK 616.336003.7-089.87-072.
39. Pospelov D. Laparoscopic cholecystectomy. Tactics and results of treatment of the most dangerous complications / D. Pospelov // Ukr. honey. hour painting. 2012-06-06
40. Renz, B. W., B^ch, F., & Angele, M. K. (2017). Bile Duct Injury after Cholecystectomy: Surgical Therapy. Visceral medicine, 33(3), 184-190. https://doi. org/10.1159/000471818
41. Latteri S, Malaguarnera G, Mannino M, et al. Ultrasound as point of care in management of polytrauma and its complication. Ultrasound. 2017;20(2):171-177
42. Antonio Pesce, Stefano Palmucci, Gaetano La Greca, and Stefano Puleo «Iatrogenic bile duct injury: impact and management challenges» Clinical and Experimental Gastroenterology • February 2019 DOI: 10.2147/CEG.S169492
43. Palmucci S, Mauro LA, Coppolino M, et al. Evaluation of the biliary and pancreatic system with 2D SSFSE, breathhold 3D FRFSE and respiratory-triggered 3D FRFSE sequences. Radiol Med. 2010 ultrasonography in the diagnosis of extrahepatic biliary pathology. Radiol Med. 2010;115(3):467-482. D0I:10.1007/ s11547-010-0508-1
44. Palmucci S, Mauro LA, La Scola S, et al. Magnetic resonance cholangiopancreatography and contrast-enhanced magnetic resonance cholangiopancrea-tography versus endoscopic ultrasonography in the diagnosis of extrahepatic biliary pathology. Radiol Med. 2010.;115(5):732 -746 DOI: 10.1007/s11547-010-0526-z
45. Stewart L. Iatrogenic biliary injuries: identification, classification, and management. Surg Clin North Am.2014;94(2):297-310.
46. Nazirov F.G., Devyatov A.V., Babadzhanov A.H., Baibekov R.R. Damage to aberrant bile ducts during laparoscopic cholecystectomy . Shoshilinch tibbiyot axborotnomasi, 2019, XII (5) UDK. 611.365-002003.6-017.
47. Sokolov A.A., Artemkin E.N., Kudishkinan I.N., Save-lyev V.S. "Bile flow in the early stages of postcholecystectomy: diagnosis and treatment» Topical issues of endoscopy, St. Petersburg, 2010.
48. Perini RF, Uflacker R, Cunningham JT, et al. Isolated right segmental hepatic duct injury following laparo-scopic cholecystectomy. Cardiovasc Intervent Radiol 2005.28:185-195.
49. Madariaga JR, Dodson SF, Selby R, et al. Corrective treatment and anatomic considerations for laparo-scopic cholecystectomy injuries. J Am Coll Surg 1994. 179:321-325.
50. Nishio H, Kamiya J, Nagino M, et al. Right hepatic lobectomy for bile duct injury associated with major vascular occlusion after laparoscopic cholecystectomy. J Hepatobiliary Pancreat Surg 1999-6:427-430.
51. Stewart L, Robinson TN, Lee CM, et al. Right hepatic artery injury associated with laparoscopic bile duct injury: incidence, mechanism, and consequences. J Gas-trointest Surg 2004-8:523-530; discussion 530- 521.
52. Way LW, Stewart L, Gantert W, et al. Causes and prevention of laparoscopic bile duct injuries: analysis of 252 cases from a human factors and cognitive psychology perspective. Ann Surg 2003. 237:460-469.
53. Scott-Conner CE, Hall TJ. Variant arterial anatomy in laparoscopic cholecystectomy. Am J Surg 1992 163:590-592.
54. Mays ET, Wheeler CS. Demonstration of collateral arterial flow after interruption of hepatic arteries in man. N Engl J Med 1974. 290:993-996.
55. Koffron A, Ferrario M, Parsons W, et al. Failed primary management of iatrogenic biliary injury: incidence and significance of concomitant hepatic arterial disruption. Surgery 2001.130:722-728; discussion 728- 731.
56. Sekido H, Matsuo K, Morioka D, et al. Surgical strategy for the management of biliary injury in laparo-scopic cholecystectomy. Hepatogastroenterology 2004.;51:357-361.
57. Slater K, Strong RW, Wall DR, et al. Iatrogenic bile duct injury: the scourge of laparoscopic cholecystectomy. ANZ J Surg 2002;72:83-88.
58. Treatment of failed Roux-en-Y hepaticojejunostomy after post-cholecystectomy bile ducts injuries / A. Benkabbou [et al.]Surgery. - 2013 Jan. - Vol. 153, N 1. - P. 95-102.
59. G. A. Pogosyan 1, A. Z. Vafin 1, A. N. Aidemirov 1,2, E. G. Mnatsakanyan 1,2, K. I. Delibaltov. Quality of life of patients after reconstructive surgery for iatrogenic injury and / or stricture of the bile ducts MEDICAL BULLETIN OF THE NORTH CAUCASUS 2014. V. 9. No. 1 DOI - http://dx.doi.org/10.14300/ mnnc.2014.09029
60. Akbarov M.M., Kurbaniyazov Z.B., Nishanov M.Sh., Rakhmanov K.E., Davlatov S.S. Features of surgical treatment of intraoperative injuries of the bile ducts // Problems of Biology and Medicine, 2013. .№2(73). C.383-384.
61. Davlatov S.S., Kurbaniyazov Z.B., Babazhanov A.S., Rakhmanov K.E., Amonov M.M. An improved method of plasmapheresis in the treatment of endotoxicosis in purulent cholangitis // Materials of the Republican scientific-practical conference "Actual problems of hepatology and HIV infection" dedicated to the World AIDS Day. Andijan, 2012.79-81 p.
62. Kurbaniyazov Z.B., Rakhmanov K.E., Davlatov S.S., Saidmurodov K.B., Zainiev A.F. Factor analysis of the results of surgical treatment of injuries of the bile ducts // National Surgical Congress in conjunction with the XX Anniversary Congress of ROEH 2017. Moscow. ISSN- 2075-6895. C. 383-384.
63. Kasimov S. et al. haemosorption In Complex Management of Hepatargia: The International Journal of Artificial Organs, 2013 T. 36. №8.
64. Saidullaev Z.Ya., Rustamov S.U. Surgery of iatrogenic injuries of the main bile ducts. https://cyberlenin-ka.ru/article/n/hirurgiya-yatrogennyh-povrezhdeniy-magistralnyh-zhelchnyh-protokov-obzor-literatury/ viewer.
65. Gal'perin EI, Vetshev PS. Mannual of bile duct surgery. Moscow: Vidar-M; 2006.
66. Johnson SR, Koehler A, Pennington LK, Hanto DW. Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy. Surgery. 2000. 2000;128(4):668-77.
67. Shapovalyants, C.G., Orlov, S.Yu., Mylnikov, A.G., Pankov, A.G., Budzinskiy, S.A., & Matrosov, A.L. (2005). Endoskopicheskoye lecheniye "svezhikh" povrezhdeniy zhelchnykh protokov.
68. Akbarov, M., Askarov, P., & Kurbaniyazov, Z. (2017). Optimization of surgical treatment of "fresh" injuries of the main bile ducts. European Multi Science Journal, (10).
