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DOI - https://doi.org/10.14300/mnnc.2019.14108 ISSN - 2073-8137
CORRECTIVE EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ON THE DAILY PROFILE OF BLOOD PRESSURE AND SOMNOLOGICAL CHARACTERISTICS IN ELDERLY PATIENTS WITH COMBINED CARDIAC PATHOLOGY
Osadchuk M. A., Vasil'eva I. N., Mironova E. D., Khudarova A. A., Korzhenkov N. P.
First Sechenov Moscow State Medical University (Sechenov University), Russian Federation
КОРРИГИРУЮЩЕЕ ВЛИЯНИЕ ИНГИБИТОРОВ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА НА СУТОЧНЫЙ ПРОФИЛЬ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ И СОМНОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ У ПАЦИЕНТОВ ПОЖИЛОГО ВОЗРАСТА С СОЧЕТАННОЙ КАРДИАЛЬНОЙ ПАТОЛОГИЕЙ
М. А. Осадчук, И. Н. Васильева, Е. Д. Миронова, А. А. Хударова, Н. П. Корженков
Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет), Российская Федерация
In recent years, a particular approach to the treatment of elderly patients with combined cardiac pathology has been gaining importance. It is aimed at adequate antihypertensive therapy and correction of chronologically occurring circadian biorhythms to study the curative effect of ramipril on the daily blood pressure (BP) profile and somnological characteristics of elderly patients with arterial hypertension (AH) and coronary artery disease (CAD). In an outpatient setting, 57 patients with the 1st and 2nd degree of stage III essential AH in combination with angina pectoris (AP) 1 and 2 functional class (FC) were examined. Patients underwent general clinical, laboratory examination, daily monitoring of blood pressure, somnological questionnaire survey. The study results allowed us to conclude that ramipril has a significant corrective effect on the regular BP profile and somnological characteristics in patients with combined cardiac pathology.
Keywords: arterial hypertension, coronary artery disease, daily blood pressure profile, circadian biorhythms, somnological disorders
В последние годы важное значение приобретает подход к лечению пациентов пожилого возраста с сочетанной кардиальной патологией, направленный на адекватную антигипертензивную терапию и коррекцию хронологически протекающих циркадных биоритмов. В проведенном исследовании изучалось влияние рамиприла на суточный профиль артериального давления и сомнологические характеристики пациентов пожилого возраста с артериальной ги-пертензией и ишемической болезнью сердца. В амбулаторно-поликлинических условиях обследовано 57 пациентов с эссенциальной артериальной гипертензией III стадии 1-й и 2-й степени в сочетании со стенокардией напряжения 1-го и 2-го ФК. Пациентам проводили общеклиническое, лабораторное обследование, суточное мониторирование артериального давления, анкетирование по сомнологическим опросникам. Результаты позволили сделать заключение о значимом корригирующем влиянии рамиприла на суточный профиль артериального давления и сомнологиче-ские характеристики у больных с сочетанной кардиальной патологией.
Ключевые слова: артериальная гипертензия, ишемическая болезнь сердца, суточный профиль артериального давления, циркадные биоритмы, сомнологические нарушения
For citation: Osadchuk М. А., Vasil'eva I. N., Mironova E. D., Khudarova А. А., Korzhenkov N. P. CORRECTIVE EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ON THE DAILY PROFILE OF BLOOD PRESSURE AND SOMNOLOGICAL CHARACTERISTICS IN ELDERLY PATIENTS WITH COMBINED CARDIAC PATHOLOGY. Medical News of North caucasus. 2019;14(3):448-453. DOI - https://doi.org/10.14300/mnnc.2019.14108
Для цитирования: Осадчук М. А., Васильева И. Н., Миронова Е. Д., Хударова А. А., Корженков Н. П. КОРРИГИРУЮЩЕЕ ВЛИЯНИЕ ИНГИБИТОРОВ АНГИОТЕНЗИНПРЕВРАЩАЮЩЕГО ФЕРМЕНТА НА СУТОЧНЫЙ ПРОФИЛЬ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ И СОМНОЛОГИЧЕСКИЕ ХАРАКТЕРИСТИКИ У ПАЦИЕНТОВ ПОЖИЛОГО ВОЗРАСТА С СОЧЕТАННОЙ КАРДИАЛЬНОЙ ПАТОЛОГИЕЙ. Медицинский вестник Северного Кавказа. 2019;14(3):448-453. DOI - https://doi.org/10.14300/mnnc.2019.14108
ABMP - daily (ambulatory) of blood pressure monitoring
ABMP profile- daily blood pressure monitoring profile
ACE inhibitor angiotensin-converting enzyme
AH arterial hypertension
AP angina pectoris
BP blood pressure
BP load Blood Pressure Load
CAD coronary artery disease
CHF chronic heart failure
CVD cardiovascular disease
DBP diastolic blood pressure
DBPV diastolic blood pressure variability
FC functional class
GBI hyperbaric index
HAI hypertension area index
HBI - hyperbaric index
HR - heart rate
HRV - heart rate variability
ISI - insomnia severity index
MBPRS - morning blood pressure rise speed
MBPSI - morning BP speed index
MBPSI of SBP - morning BP speed index
MH - morning hypertension
MI - myocardial infarction
NBP dip (dipping) - the degree of nocturnal blood pressure decrease
PBP - pulse blood pressure
SBP - systolic blood pressure
SBPV - systolic blood pressure variability
Cardiovascular disease (CVD), dominant in the structure of morbidity and general mortality worldwide, is the subject of global health close attention. The practical importance of studying this problem is also due to combined cardiac pathology high prevalence, among which the leading positions belong to СAD and AH [1]. Factors unity contributing to the occurrence of both CAD and AH indicates a certain similarity in their development, despite different time intervals from the factor's onset to their influence manifestation [2]. Besides, these diseases unifying aspect is the isomorphism of the pathogenetic process various parts, whose study in recent years has been the subject of many works [3].
An increase in the tone of the sympathetic nervous system and activation of the hypothalamic-pituitary-adrenal systems in patients with AH and CAD is manifested by circadian biorhythms desynchronosis, which contributes to somnological disorder development [4]. Moreover, chronic sleep disorders can significantly aggravate the CVD course [5]. In this regard, an individual approach to cardiac patients' treatment is gaining importance, aimed not only at compensating for the underlying disease, but also correcting circadian biorhythms.
Of course, a significant pharmacological revolution occurred in the 70s. XX century, when a group of scientists led by D. W. Cushman and M. A. Ondetti synthesized the first inhibitor of the angiotensin-converting enzyme (ACE inhibitor) - captopril. This event mainly influenced the further evolution of views on this class representatives' role in CVD treatment. For a long time, the only indication for ACE inhibitors use was hypertension. Subsequently, the first randomized CAPPP (The Captopril Prevention Project) test demonstrated the effective captopril ability to influence the reduction in complications and mortality frequency in patients with hypertension [6].
Later the results of numerous studies presented not only useful antihypertensive qualities of this drug group but also proved its beneficial effect on cardiovascular continuum in general. Thus, the GISSI study had an ACE inhibitors positive effect on the prognosis of patients with acute myocardial infarction (Ml) by reducing mortality while taking lisinopril [7]. The SMILE study results showed reducing mortality and the risk of developing chronic heart failure (CHF) in MI patients zofenopril treatment. The SMILE-4 study result was a standardized death rate decrease in men over 76 with chronic heart failure when taking this drug [8]. Over time, the prognostic effect on cardiovascular outcomes in patients with CVD has been proven for other ACE inhibitors [9-11]. And no one doubts that ACE inhibitors are deservedly the first-line drugs in the treatment and prevention of socially significant diseases, which, of course, include CHF, AH, and CAD.
In the Russian guidelines for the management of patients with stable angina, perindopril and ramipril are preferred as drugs with proven anti-ischemic efficacy [12]. Ramipril, having the ability to influence all cardiovascular continuum parts and prevent cardiovascular complication development, significantly reduces death risk in both young [13] and older people [14]. Based on this, ACE inhibitors should be considered the essential component of the complex therapy of patients with combined cardiac pathology, regardless of age. Because of the preceding, this study aimed to study the corrective effect of ramipril on the daily blood pressure profile (ABMP), its circadian biorhythms, and somnological characteristics in elderly patients with a combination of AH and CAD.
Material and Methods. On an outpatient basis, 57 elderly patients with the 1st and 2nd degree of stage III essential AH in combination with CAD were examined (19 men, 38 women; average age - 70.6±7.2 years). Most patients (86.6 %) had the 2nd AP FC, and 7.5 % of patients had an MI history. The average duration of hypertension was 9.3±1.7 years and coronary heart disease - 4.6±1.1 years.
Exclusion criteria: patients with symptomatic AH, grade III AH, unstable AP, valvular heart disease, MI or stroke for less than six months, severe rhythm disturbances, and decompensated concomitant diseases.
In addition to general clinical and laboratory examination, all patients underwent 24-hour blood pressure monitoring (ABPM) with the use of the BPLab complex of hardware-software BP monitoring (Russia). The study results assessment was carried out, taking into account the ABPM parameters linear analysis in consent with European recommendations [15]. The mean, maximum, and minimum systolic BP (SBP) and diastolic BP (DBP) values, their variability, and pulse BP (PBP) per day were determined. Quantitative assessment of the «pressure load» value was carried out by the BP load, hyperbaric index (HBI). Given the available biphasic daily fluctuations in all patients' BP, the degree of nocturnal BP decrease (NBP dip) was evaluated. Its maximum values determined the standard parameters of the morning BP rise in the morning hours, morning hypertension (MH) values, it's rate, as well as the combined «index of morning hours» (MBPSI). Daily ECG monitoring (ECG DM) was performed for 24 hours when antianginal drugs had been canceled a day before the study using a BTL-08 ECG HOLTER electrocardiograph (Great Britain). The number of myocardial ischemia episodes with ST-segment deviation and their average duration was taken into account. To identify possible sleep disorders, the somnological questionnaire «Subjective assessment of sleep characteristics» (A. M. Wayne, Y. I. Levin) was used [16]; somnological disorders severity was assessed using the «Insomnia Severity Index» (ISI) (C. Morin) [17].
According to the clinical recommendations for stable AP diagnosis and treatment [12], all patients were prescribed standard-essential therapy, including acetylsalicylic acid (class I recommendations with evidence level A), atorvastatin (class I, level A) at an average dose of 15.8±0.6 mg/day and metoprolol succinate (class I, level A) at a dose of 50.4±11.6 mg/day.
The preliminary treatment results were evaluated after two weeks. The criterion for the anti-ischemic therapy effectiveness was a reduction in the frequency of angina attacks per week and the patient's need for nitroglycerin. The criterion of antihypertensive therapy efficacy was a decrease in blood pressure (office) <140/90 mm Hg, and more from the initial level. The criterion of blood pressure normalization in people of the older age group (from 65 to 79 years) was the SBP level of up to 130-139 mm Hg. (with good tolerance not<120 mm Hg), and the DBP level of up to 70-79 mm Hg. In the absence of the desired effect, patients who did not have significant improvement within two weeks (n=41) were divided into two groups using random selection. Patients of the 1st group (n=21) continued essential therapy with an increase in the dose of p-blocker to the maximum tolerated (61.8±12.5 mg/ day). In patients of the 2nd group (n=20), the ACE inhibitor ramipril was added to the particular treatment regimen (average dose of 7.9±1.8 mg/day). Patients dynamic monitoring was carried out over ten weeks.
The results of statistical processing were carried out using STATISTICA 10.0 (StatSoft, USA). When performing the calculations, standard descriptive statistics methods were used; the mean value (M) and the standard deviation (SD) were estimated. Quantitative values were presented in the form of a record M±SD with indicating frequency and percentage. Taking into account the available sample of a small volume, nonparametric statistical methods were used. The reliability of the indicators' dynamics was assessed using the Wilcoxon test, intergroup differences according to the x2 criterion. The probability value p<0.05 testified to statistical significance.
Results and Discussion. According to the results obtained, after 10 weeks' regular treatment, an improvement in the clinical status of both groups representatives was observed, as evidenced by changes in the AP FC of individuals participating in the study. In the 1st comparison group, the number of patients with FC I AP increased by 39.9 % (from 28.6 % to 47.6 %; p=0.06), the duration of ST segment depression according to the Holter ECG decreased to 1.3±0.08 min (A=-35.6 %; p=0.09), the need for nitroglycerin decreased from 2.39±0.19 to 1.25±0.17 per week (A=-47.7 %; p=0.03). In representatives of the 2nd group, the dynamics was more pronounced. The number of patients with FC I AP increased to 60.0 % (A=-58.3 %; p=0.04), the duration of ST segment deviation was reduced to 1.2±0.03 min (A=-44.6 %; p=0.06), and the application frequency of short-acting nitrates per week - from 2.37±0,22 to 0.94±0.14 (A=-60.3 %; p=0.01).
By the end of the observation period clinical blood pressure studies had showed a significant decrease in representatives of all SPB and DBP groups. In patients of the 1st group, SBP (office) decreased by 9.7 % (from 150.1±3.8 to 135.5±2.7 mm Hg; p=0.001), DBP - by 9.4 % (from 89.3±2.0 to 80.9±1.7 mm Hg; p=0.001), while in persons of the 2nd group - by 16.1 % (from 150.6±5.1 to 126.3±2.1; p=0.0001) and 15.0 % (from 90.3±1.8 to 76.8±1.5 mm Hg; p=0.0001), respectively. 47.6 % (n=10) of the 1st group patients and 71.4 % (n=15) of the 2nd group ones, who took ramipril, reached the target blood pressure values.
A statistically significant decrease in the daily ambulatory BP monitoring (ABPM) values detected in patients of both groups, regardless of the chosen therapy, indicated a reduction in pressor load during treatment (Table 1). However, ramipril therapy was accompanied by significant dynamics in pressure loading parameters (according to the x2 criterion; p<0.05), thereby providing a significant contribution to the positive prognosis of patients with high cardiovascular risk.
Тable 1
ABMP indicators' dynamics during therapy
Indicators 1st group (n=21) 2nd group (n=20)
Initially After 10 weeks P Д Initially After 10 weeks P Д
Daily SBP, mm Hg 143.9±2.5 131.6±2.7 0.003 -9.0 % 143.8±4.5 123.7±2.2 0.0001 -14.0 %
Daily DBP, mm Hg 87.2±1.8 78.4±1.5 0.003 -10.1 % 89.9±1.5 76.6±1.1 0.004 -14.8 %
Daily HR, beats/min 74.8±2.2 64.5±1.4 0.001 -13.7 % 72.9±1.8 63.9±1.3 0.0001 -12.3 %
Daily PBP, mm Hg 59.8±1.3 53.1±2.1 0.004 -11.2 % 61.2±2.0 51.9±1.4 0.0003 -15.2 %
Mean daily BP, mm Hg 104.7±2.7 96.3±2.1 0.03 -8.6 % 105.9±2.6 94.7±1.4 0.001 -10.6 %
Daily SBPV, mm Hg 15.9±0.8 14.0±0.7 n/d -11.6 % 16.2±0.8 14.1±0.6 0.06 -13.1 %
Diurnal SBPV, mm HG 16.0±0.7 14.1±1.0 n/d -11.8 % 16.1±0.9 14.2±0.7 n/d -11.8 %
Nocturnal SBPV, mm Hg 15.7±0.8 13.9±0.9 n/d -11.4 % 15.8±1.0 13.6±0.7 0.09 -13.9 %
Daily DBPV, mm Hg 13.3±0.6 12.2±0.4 n/d -8.3 % 13.1±0.7 11.3±0.9 n/d -13.7 %
Daily HRV, beats/min 8.9±1.0 7.3±0.2 0.04 -18.0 % 8.8±0.9 7.4±0.6 0.04 -15.9 %
Daily HBI of SBP, % 239.2±34.6 189.2±28.2 0.001 -20.9 % 240.5±36.9 159.0±39.7 0.0003 -33.9 %
Daily HBI of DBP, % 102.0±33.5 83.8±12.4 0.003 -17.8 % 103.2±24.6 64.4±9.8 0.0001 -37.6 %
Daily BP load of SBP, % 69.6±5.3 46.1±6.2 0.001 -33.7 % 70.4±4.2 36.9±3.6 0.001 -47.6 %
Daily BP load of DBP, % 56.7±5.2 40.4±5.8 0.05 -28.7 % 56.9±5.3 30.1±3.9 0.001 -47.1 %
MBPSI of SBP, mm Hg/min2 895.7±92.2 739.5±85.9 0.04 -17.4 % 894.0±102.1 608.2±96.4 0.002 -32.0 %
MBPSI of DBP, mm Hg/min2 414.5±69.7 326.6±65.4 0.03 -21.2 % 415.5±67.3 299.8±62.2 0.003 -27.8 %
a.m. SBP rise, mm Hg 50.3±4.5 43.3±2.6 0.04 -13.9 % 50.3±3.9 39.8±3.1 0.04 -20.9 %
a.m. DBP rise, mm Hg 35.6±2.7 33.8±2.0 n/d -5.1 % 35.4±2.8 30.2±2.9 n/d -14.7 %
a.m. SBP rise rate, mm Hg 19.1±1.2 16.2±0.9 0.03 -15.2 % 19.1±1.8 14.1±0.9 0.01 -26.2 %
a.m. DBP rise rate, mm Hg 19.6±2.1 17.2±1.8 n/d -12.2 % 19.4±2.3 15.2±1.6 0.01 -21.6 %
Note. The data are presented in M±SD; A and p are indicated in comparison with the initial data.
The pulse blood pressure (PBP) role in CVD development being determined, its exceeded value, initially found in all patients, indicated vascular wall rigidity and increased hyperbaric load, as a result of the reflection wave appearance. The ramipril ability to suppress vascular endothelial cell proliferation was first demonstrated in the SECURE study [18], whose results showed a 37 % slower atherosclerosis progression when using ramipril. Later, the AIREX study revealed ACE inhibitors' ability to reduce cardiovascular complications and standardized death rate indicators (A=-36,0 %) through its angioprotective property [19]. Therefore, patients with an initially high PBP should be prescribed pathogene-sis-based therapy affecting systemic hemodynamics parameters to improve their prognosis.
Due to elderly patients' impaired regulatory mechanisms, special attention was also given to the highspeed BP characteristics -the magnitude and speed of the morning rise. It is known that MH is an integral indicator, which depends primarily on the BP increase time and magnitude, and neither BP daily rhythm nor its mean values have an effect on it. Therefore, the correlation between the morning BP rise and the variability of the mean daily SBP, DBP, PBP values, and myocardial mass index [20], established in some studies, is surprising. The MH in both groups had upper threshold values; the morning BP rise speed significantly exceeded the normative limit. And only in patients of the 2nd group taking ramipril, by the end of the observation period, the speed and magnitude of the morning BP rise had significantly decreased (p<0.05).
Taking into account cardiovascular events increase in the early hours, we also considered the positive dynamics of the combined integral morning hours index as a criterion for normalizing BP during the therapy course: morning BP rise speed index (MBPRSI)=d / dt (BP) x BP x heart rate (mm Hg) 2xmin-2). It should be noted that in both comparison groups there was a significant change in this indicator values, more significant for patients of the 2nd group (with intergroup comparison A=-32.0 %; p<0.05), which showed ACE inhibitors corrective effect on morning risk factors cardiovascular complications, as well as sleep quality characteristics.
The successful tactics of treating patients with AH and CAD lie in its ability to influence the regular physiological circadian activity of neurohumoral systems, thereby forming an entirely new - chronobiological - approach to the treatment of patients with high cardiovascular risk. It is known that several neurohumoral systems are involved in BP circadian rhythm formation, which determines the synchronized blood pressure fluctuations pattern during the day [21]. The circadian body rhythms mismatched with the environmental ones are called external desynchronosis, which occurs even in a healthy person (during air travel). Internal desynchronosis manifests itself in a violation of the natural relationships between various body systems' daily biorhythms. As described by B. S. Alyakrinsky, it is observed in multiple
diseases and involutive states [22]. Therefore, special importance was attached to the analysis of the circadi-an BP rhythm according to the dynamics of the NBP dip (Table 2). The positive therapy effect on blood pressure variations was determined mainly by the transition of «non-dipper» and «night-peaker» to the «dipper» group, whose number increased to 75.0 % in the 2nd group (p<0.05). A detailed ABMP profile analysis revealed a high prevalence of pathological blood pressure profiles in older women (22 people), which indicates a more significant internal circadian biorhythms desynchronosis and explains the higher incidence of various sleep disorders in them compared to men.
Table 2
Recent studies show the connection of circadian biological rhythms desynchronosis and sleep disorders with various psychosomatic diseases [23]. Besides, night rest duration decreases to 5 hours a day or less causes an increase in mortality, especially in people of an older age group. The most common type of sleep disturbance is insomnia - a syndrome characterized by impaired initiation, duration, and consolidation of sleep resulting in impaired daily activities. Insomnia is associated with numerous social and medical consequences and is widespread in the general population [24]. According to A. V. Golenkov and M. G. Poluektov's research results, the frequency of sleep disorders that occur in the elderly and senile in the Russian Federation, reaches 32.9 % [25]. The initial questionnaire of patients who took part in the study showed various sleep disorders high incidence (70.7 %), despite the sufficient duration of its total time (8.32±1.74 hours). Borderline sleep changes (>19 points) were detected in 31.0 % of patients, and signs of severe insomnia (<less than 19 points) were detected in 69.0 %. Elderly patients with a combination of AH and CAD most often had difficulty falling asleep (53.7 %), too early morning awakening (48.8 %), respiratory failure in sleep (34.5 %), and coughing with interruption (31.0 %). With BP daily profile normalization during therapy, subjective sleep characteristics improved, especially in patients taking ACE inhibitors (Table 3): the time to fall asleep decreased (A=-19.4 %; p=0.001), morning awakening quality improved (A=-24.2 %; p=0.001). Also, ramipril therapy effectiveness was manifested by a statistically significant decrease in insomnia severity index by 22.3 % (p=0.04) and by 19.0 % (p=0.03)
The dynamics of daily BP rhythm indicators according to nocturnal SBP dipping in patients of both groups during therapy
BP profile 1st group (n = 21) 2nd group (n = 20)
Initially 10th week P Initially 10th week P
SBP dipper, % 38.1 57.1 0.04 30.0 60.0 0.01
non-dipper, % 33.3 23.8 0.07 50.0 25.0 0.02
over-dipper, % 4.8 4.8 1.0 0 0 1.0
night-peaker, % 23.8 14.3 0.046 20.0 15.0 0.7
DBP dipper, % 47.6 66.7 0.02 45.0 75.0 0.04
non-dipper, % 42.9 28.5 0.04 40.0 15.0 0.03
over-dipper, % 0 0 1.0 5.0 5.0 1.0
night-peaker, % 9.5 4.8 0.8 10.0 5.0 0.7
Circadian index 1.22±0.03 1.24±0.02 0.12 1.21±0.03 1.24±0.03 0.09
Note. The data are presented in % and M±SD.
overall assessment dynamics of subjective sleep and blood pressure profile synchronization with rami-characteristics, which can be explained by daily rhythm pril.
Table 3
Subjective assessment dynamics of sleep characteristics and Insomnia Severity Index during therapy
on somnological questionnaires
Analyzed parameters, score 1st group (n = 21) 2nd group (n = 20)
Initially After 10 weeks Initially After 10 weeks
Time of falling to sleep 2.6±0.8 2.9±0.5* 2.5±0.7 3.1±0.5*
Sleep duration 2.9±0.5 3.0±0.9 2.8±0.7 3.1±1.0
Number of awakenings 2.9±0.7 3.2±0.5* 2.9±0.6 3.2±0.8
Sleep quality 3.0±0.9 3.2±0.6 3.1±0.9 3.2±0.8
Number of dreams 2.5±0.5 2.6±0.8 2.8±0.8 2.8±0.5
Morning awakening quality 3.0±0.9 3.2±1.2 2.9±0.9 3.6±0.7*#
Total score 15.7±3.1 18.0±2.5* 15.8±2.9 19.5±3.0*#
Insomnia Severity Index 18.4±4.0 16.9±3.3 18.8±3.7 14.6±2.6*
Note: * - p<0.05 for intragroup dynamics; # - p<0.05 for differences between groups 1 and 2.
Conclusions. Thus, the results of this study made it possible to conclude a significant corrective ramipril effect on the daily BP profile and somnological characteristics in patients with AH in combination with CAD. Ramipril
Disclosures:
The authors declare no conflict of interest.
organoprotective properties allow not only to slow down AH and CAD progression, but also to implement a completely new - chronobiological - approach to the treatment of elderly patients with high CVR.
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About authors:
Osadchuk Mikhail A., MD, PhD, DSc, Head of the Department of polyclinic therapy;
tel.: +79160712626; e-mail: [email protected]; ORCID - 0000-0003-0485-6802
Vasil'eva Inna N., MD, Associate Professor of the Department of polyclinic therapy; tel.: +79851999214; e-mail: [email protected]; ORCID - 0000-0001-8335-1380
Mironova Ekaterina D., Clinical resident physician of the Department of polyclinic therapy; tel.: +79152094094; e-mail: [email protected]; ORCID - 0000-0003-3268-2408
Khudarova Anastasia A., Clinical resident physician of the Department of polyclinic therapy; tel.: + 79264574345; e-mail: [email protected]; ORCID - 0000-0002-0689-793
Korzhenkov Nikolay P., MD, Department of polyclinic therapy;
tel.: + 79154842748; e-mail: [email protected]; ORCHID - 0000-0003-1702-7923
© Group of authors, 2019 UDC 61:616.61
DOI - https://doi.org/10.14300/mnnc.2019.14109 ISSN - 2073-8137
HEART REMODELING AND QUALITY OF LIFE IN PATIENTS
WITH CHRONIC KIDNEY DISEASE ON RENAL REPLACEMENT THERAPY
Urazlina S. E., Zhdanova Т. V., Zueva Т. V., Kuznetcova Е. V. Ural State Medical University, Ekaterinburg, Russian Federation
РЕМОДЕЛИРОВАНИЕ СЕРДЦА И КАЧЕСТВО ЖИЗНИ У ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК, ПОЛУЧАЮЩИХ ЗАМЕСТИТЕЛЬНУЮ ПОЧЕЧНУЮ ТЕРАПИЮ
С. Е. Уразлина, Т. В. Жданова, Т. В. Зуева, Е. В. Кузнецова
Уральский государственный медицинский университет, Екатеринбург, Российская Федерация
The correlation between structural and hemodynamic parameters of the heart and Quality of life (QOL) parameters have been studied in chronic kidney disease (CKD) patients on hemodialysis (HD), continuous ambulatory peritoneal dialysis (CAPD) and kidney transplant recipients (KTR). Patients were divided into three groups according to the type of RRT. CKD stage 3 patients were in the control group.
The significant correlation has been founded between the values of the myocardial mass index (LVMI), end-diastolic size (LVEDS), end-diastolic volume (LVEDV), end-systolic size (LVESS), end-systolic volume (LVESV), ejection fraction (LVEF) of the left heart ventricle and QOL among patients on RRT with minimal structural and functional changes in the heart. A negative correlation has been founded between LVMI, LVEDS, LVEDV and physical health component (PF). A decrease in LVEF, as well as an increase in LVESS and LVESV, was associated with the deterioration in both indicators of physical (PF, RP) and psychological health (SF).
Keywords: quality of life, renal replacement therapy, structural changes in the left heart ventricle
У больных с хронической болезнью почек (ХБП), находящихся на лечении гемодиализом (ГД), постоянным амбулаторным перитонеальным диализом, и у реципиентов аллотрансплантации почки (АТП) наблюдалась взаимосвязь структурных и гемодинамических показателей сердца с параметрами качества жизни (КЖ) при достигнутых целевых клинико-лабораторных значениях заместительной почечной терапии (ЗПТ). В исследование включены пациенты с ХБП 5, выделенные в подгруппы по методу ЗПТ В контрольную группу вошли пациенты с ХБП 3.
При минимальных структурно-функциональных изменениях сердца у больных, получающих ЗПТ, выявлена достоверная взаимосвязь между значениями индекса массы миокарда левого желудочка (ИММЛЖ), конечно-диасто-
