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CORRECTION OF BLOOD HYPERTENSION BY HERBAL MEANS Mejidova U.M.1, Babayeva S.M.2, Magerramova S.H.3, Gasimova G.N.4, Veliyev P.M.5, Veliyeva M.N.6 Email: Medzhidova662@scientifictext.ru
'Mejidova Ulkar Mirzaga gizi - Master of Philosophy of Biological Sciences, Assistant-professor of Pharmacology; 2Babayeva Svetlana Mamed gizi - Master of Philosophy of Biological Sciences, Assistant-professor; 3Magerramova Sevinj Huseynbala gizi - Master of Philosophy of Pharmaceutical Sciences, Assistant Professor; 4Gasimova Gulnara Nisan gizi - Master of Philosophy of Pharmaceutical Sciences, Senior Teacher, PHARMACOLOGY DEPARTMENT, AZERBAIJAN MEDICAL UNIVERSITY; 5Veliyev PervizMustafa ogli - Doctor of Philosophy of Medical Sciences, Colonel, TREATMENT- PROPHYLAXIS ORGANIZATIONAL DEALS OF MEDICAL SERVICE, MINISTRY OF EMERGENCY SITUATIONS OF THE REPUBLIC OF AZERBAIJAN; 6Veliyeva Mahbuba Nabi gizi - Doctor of pharmaceutical Sciences, Professor, Head of Department, PHARMACEUTICAL TECHNOLOGY AND PHARMACY ORGANIZATION DEPARTMENT AZERBAIJAN MEDICAL UNIVERSITY, BAKU, REPUBLIC OF AZERBAIJAN
Abstract: at present increasing relevance is acquired by a problem of correction of arterial hypertension and also lipid balance correction with complications and without complications which arise refer to inactive life and also stresses and neuroses and so on. Many scientists of the world had been elaborated enough preparations, which are successfully used in practice of treatment as therapists, neuropathologists.
Various preparations having high biological activity at their introduction to a macroorganism influence not only the pathology center, but also healthy fabrics that irreparable harm can be sometimes done. Pharmaco-therapeutic activity of herbal natural means, tincture infusion of a peel of a lemon andflowers of laurels noble, for correction of cardiovascular activity and lipid disorders at patients had been investigated. Taking into account the aforesaid at the Department of Pharmaceutical Technology and Pharmacy Organization of Azerbaijani Medical University scientific research, to concern development and creations of remedies on the basis of natural raw materials of Azerbaijan including usage of alcohol infusion of a peel of a lemon with flowers of laurels noble is being conducted.
Data on development of natural alcohol infusion lemon peel infusion with flowers of laurels of noble, received from herbs offlora the Azerbaijan are for the first time provided in the scientific article. Detaily studied the usage process of tincture infusion of a peel of a lemon with flowers of laurels noble in cases of patients, which were being suffered by arterial hypertension and lipid disorders in organism. It is investigated, therapeutic efficiency at arterial hypertension by neurogenic etiology. It is possible to offer for recommendation tincture of a lemon peel infusion with flowers of laurels noble administration as a correction therapy at patients, which suffer by arterial hypertension of mild cases of clinical severities. Keywords: flowers of laurels noble, alcohol extraction of a peel of a lemon, CVS-cardio-vascular system, sedative, herbal means, lipid disorders.
КОРРЕКЦИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ РАСТИТЕЛЬНЫМИ
СРЕДСТВАМИ
Меджидова У.М.1, Бабаева С.М.2, Магеррамова С.Г.3, Гасымова Г.Н.4, Велиев П.М.5, Велиева М.Н.6
'Меджидова Улькар Мирзага гызы - кандидат фармацевтических наук, доцент; 2Бабаева СветланаМамед гызы - кандидат биологических наук, доцент; 3Магеррамова Севиндж Гусейнбала гызы - кандидат фармацевтических наук, доцент; 4Гасымова Гюльнара Нисан гызы - кандидат фармацевтических наук, старший преподаватель,
кафедра фармакологии, Азербайджанский медицинский университет; 5Велиев Первиз Мустафа оглы - кандидат медицинских наук, полковник, лечебно-профилактический отдел медицинский службы МЧС Азербайджана; 6Велиева Махбуба Наби гызы - доктор фармацевтических наук, профессор, заведующий кафедрой, кафедра фармацевтической технологии и организации фармации, Азербайджанский медицинский университет. г. Баку, Азербайджанская Республика
Аннотация: в настоящее время все большую актуальность приобретает проблема коррекции артериальной гипертензии с осложнениями и без осложнений, а самое важное коррекция липидного обмена, которая возникает в связи с малоподвижным образом жизни, а также стрессами и неврозами и т.д. Многими учеными мира разработано достаточное количество препаратов, которые успешно используются в практике лечения как врачей-терапевтов, так невропатологов и врачей других специальностей.
Различные синтетические препараты, обладающие высокой биологической активностью, при введении их в макроорганизм влияют не только на очаг патологии, но и на здоровые ткани, чем иногда может быть нанесен непоправимый вред.
Исследована фармакотерапевтическая активность натурального растительного средства, спиртового настоя кожуры лимона с цветками лавра благородного, для коррекции сердечнососудистой деятельности у пациентов.
В научной статье впервые приводятся сведения по разработке натурального настоя спиртового настоя кожуры лимона с цветками лавра благородного, полученного из лекарственных растений флоры Азербайджана. Подробно изучено применение настойки кожуры лимона с цветками лавра благородного у больных. Исследована терапевтическая эффективность при артериальной гипертензии, при нарушении сна, фобиях, также при нарушении липидного обмена у больных неврогенного характера.
Ключевые слова: цветки лавра благородного, спиртовой экстракт кожуры лимона, атеросклероз, седативное, растительное средство, липопротеиды высокой и низкой плотности.
Atherosclerosis - is the reason of cardiovascular diseases, such as coronary heart disease (CHD), myocardial infarction, heart failure, brain stroke, violation of blood circulation of extremities and abdominal organs.
Atherosclerosis - as also chronic focal damage of arteries which characterized by adjournment and accumulation in an internal cover (endothelium) of a vessel of fat-containing proteins and the cholesterol delivered by them, is also followed by growth of connecting fabric and formation of so-called atherosclerotic plaques is considered to be, and as a rule it leads to narrowing of a gleam of an artery and the chronic slowly increasing insufficiency of blood supply of body is caused.
It is necessary to take into account a possibility of sharp obstruction (occlusion) of a gleam of a vessel blood clot, or contents of the broken-up ateromatozic plaque.
Thus, that problem of atherosclerosis demands further investigations for the purpose of identification of the most effective approaches of diagnostics and treatment [5. С. 58-62].
Unfortunately, to be provided in domestic literature data that atherosclerotic plaques had been found even in vessels at small children. Among aged people, the prevalence of atherosclerotic defeat of vessels reaches up to 100%.
For adjournment of fats in an artery wall, conditions are necessary: micro- damage of a wall of an artery, delay of speed of current of blood to this place. As a rule, more often, it occurs in places of a branching of a vessel. The vascular cover is being became swells, loosened and weakened in a tone. Duration of this stage is various.
In development of a disease, cholesterol, which it is necessary to investigate theoretically, takes place. Cholesterol - it is known from literature the major lipid. The human body contains about 140 g of this substance. Performs various physiological functions; formation of bilious acids, D3 vitamin, sex hormones and corticosteroids.
The cell, as a rule, at all mammals contains cholesterol in an organism and needs in maintenance of a configuration (so-called cholesterol function in formation of a phospholipid membrane). Cholesterol in cell membranes has also relation to its temperature stability.
Most of all cholesterol is available in cortical substance of adrenal glands; in a brain and nervous tissue; it is less - in vessels, a liver, kidneys, a spleen, marrow; the smallest quantity - in skeletal muscles and connecting fabric. Depending on food and a way of life from about, 300 to 500 mg of cholesterol, which is soaked up for, needs of an organism daily come to a human body. Daily requirement - about 1.4 g, but if it is not enough, then synthesizes an organism itself (mainly in a liver) how many it is required. That is that food cholesterol is not a factor of development of atherosclerosis at all.
In plasma, cholesterol circulates freely, in the form of complexes with proteins and lipids - in so-called lipoproteids by means of which its transport is realized. As is well-known in literatures of a lipoproteids are being divided into atherogenous fractions (lipoproteids of low density - LDL and lipoproteids of very low density - LPONP) and not atherogenous (lipoproteids of high density -LPVP). The problem of atherogenous lipoproteids is a delivery of cholesterol in cells and tissures
where it is required; the task not atherogenous is to collect excess cholesterol for the purpose of its utilization. It should be noted that collecting goes also from walls of arteries that is at atherosclerosis of LPVP show obviously curative action! Growth of that fraction is the factor promoting health and longevity. Therefore in a popular speech of LDL and LPONP call in literature, as a rule, bad cholesterol, and LPVP - good is being considered.
The blood picture - so-called violation of hormonal and mineral structure has huge value. It is indisputable, that is value of so-called risk factors of development of atherosclerosis. Risk factors: smoking, excess body weight, high level of cholesterol in blood, high pressure, stresses, an inactive way of life [11. 53].
So, during medical examination of staff of the Ministry of Emergency Situations of the Republic of Azerbaijan, one of major factors is an arterial hypertension which was being noted-24.6%, diabetes made-6.67% from total number of all factors and diseases, which was the reason of formation of big portion of cholesterol [5. C. 58-62].
There are well-known methods corrections of risk factors at patients with excess formation of cholesterol [5. C. 58-62].
Treatment of atherosclerosis - as a rule, is a difficult problem. There are no preparations which can solve the problem at once. Each patient can have features of a course of disease. Therapy of atherosclerosis demands long time, almost during of life, demanding considerable economic expenses [5. C. 58-62].
' ■ 24,6%
10,21%
7,950/0
_ 6,67%
5,64% 5,39% - 5.51%
_ 5,0%
Fig. 1. Diagram. Comparative percentage diseases analyses of staff at the Ministries ofEmergency Situations refer to medical examination ofstafffor period of2019 year. 1 -Hypertonia, 2-nd stage of obesity, 3 -steoxondrosis, 4 - Diabetes, 5 - Otorinolaringologic diseases, 6 - Chronic gastritis, 7 - Rheumatic active phase, 8 -
Others, 9 - Others, 10 - Others
The objective of the article was identification of pharmacotherapeutic activity of herbal means, alcohol infusion of a peel of a lemon and flowers of laurels noble, for correction of cardiovascular activity and lipid disbalances at patients suffered by atherosclerosis.
Flowers of laurels noble - (laurels noble) - natural antiseptics, has anti-inflammatory properties and renders effect of anesthesia, possess sedative action, and improve a dream. As a part of laurels noble there are fat oil, organic acids, tannins and essential oil, [12].
The lemon peel - the dried peel of a lemon is rich with flavonoids, ascorbic acid, food fibers, vitamins, minerals, pectin, essential oil, coumarins and phytoncides. [12].
Materials and methods: As object of a research served tincture of a lemon peel, with flowers of laurels noble being elaborated by us, reffer to a technique of two-phase extraction by water and 60% ethyl alcohol. Objects of a research were 3 patients with arterial hypertension. On the basis of data the investigated persons were being divided into 2 groups:
Table 1. Distribution of investigated patients in groups
The studied patients with arterial hypertension Group of patients
Control group Comparative group
Patients without complications 2 3
Patients with complications 2 3
Total number 4 6
р<0,05.
All examined patients were aged from 40 up to 50 years. In investigation process of patients are being included: collecting the anamnesis, clinical examination, carrying out laboratory tools and blood method tools, urine and computer brain researches also biocemical tools related with lipid fractions.
By us, it is offered, tincture infusion of a peel of a lemon with flowers of laurels noble as sedative, anesthetic, strengthening walls of vessels, hypotensive mean and as mean for improvement of night sleep for therapy of patients with arterial hypertension with complications of an ischemic stroke in case of middle clinical severity.
Appointed preparation, tincture infusion of a peel of a lemon with flowers of laurels noble was being administrated in a dosage of 50 ml 1-2 times a day after a meal during a monthly course of treatment at patient of control group.
The control group of patients, before accepted previously treatment, in the subsequent and they fully refused from the treatment in a hospital. The investigation process of the blood test and urine were carried out by a usual method.
Biochemical blood test was being carried out in particular: the fraction of cholesterol and lipids and also sugar on a hungry stomach was being investigated. Brain researches were being checked by computer.
Hemodynamic parameters were being used as necessary part of clinical examination. The tonometry method with a usage of the Sphygmo Cor device (Australia) for definition of the indicators.
Researches of indicators were conducted. Statistical data processing was carried out with a usage of Student criteria. (Calculated average size - X, an average quadratic deviation - and an error of average size -t. For determination of the statistical importance of distinctions t-Student's criterion was calculated).
Results and discussions: Material data of investigation was, tincture infusion of a peel of a lemon with flowers of laurels noble being developed by us at Department of Pharmaceutical Technology and Management of the Azerbaijan Medical University in the Republic of Azerbaijan which was received on the basis of flowers of herbs.
Blood test. Blood test of investigated patients was carried out. It was noted the raised speed of erythrocytes sedimentation as usual. Special pathological changes were not revealed.
Table 2. Dynamical process of clinical findings at investigated patients with hypertension of mild case related with application of tincture infusion of a peel of a lemon with flowers of laurels of noble per os during a month
Duration of investigation process CABP мм^. CDBP мм^.
Initially 150,5±0,3 99,2±0,2
After a month therapy with spirit infusion usage of a peel of a lemon with flowers of laurels noble. 140,1± 0,2 85,2± 0,5
* р =0.05.
Coagulogramm test also was being carried out but special disorders were not observed. Coagulation test refer to Movaris's method was being out but the results were normal. No special pathological disorders were found. The investigated result of sugar on a hungry stomach was normal. Results fraction of cholesterol were being normal and calcium maintenance in blood was normal also.
However, the obtained results of triglycerides of investigated patients were raised up normal almost twice. That data is very disputable.
Clinical findings. It was being offered by us tincture infusion of a peel of a lemon with flowers of laurels noble for correction of arterial hypertension and sedative mean which was administrated by per os after a meal.
During administration of tincture infusion of a peel of a lemon with flowers of laurels noble at investigated patients was observed the tendency for normalization of arterial blood pressure approximately from 160/90 mm.Hg to 140/90 mm Hg. It was noted sedative effect, improvement duration of sleeping process the night (approximately within 5-6 hours), some patients noted the dreams in process of sleeping, the cheerfulness after sleeping process, the little anesthetizing clinical effect in head, tremor of hands was decreased and decreased the sign of phobia symptom in several patients.
In several patients the feeling of mobility and appetite improvement were noted. Sometimes, the condition of short-term increasing of arterial blood pressure after long deep sleeping in the night was observed. Above mentioned situation was possible to correct with administration of intramuscular solution of papaverin hydrochloride injection. Positive dynamic findings related with investigation of ECG were noted particularly with - T improved. The physical and mental dependence data were not observed.
Conclusions. Thus, it is possible to offer for recommendation tincture of a lemon peel infusion with flowers of laurels noble administration as a correction therapy at patients which suffer by arterial hypertension of mild cases of clinical severities. Side-effects were not observed.
References / Список литературы
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АНАЛИЗ РЕГИСТРА НЕФРОБИОПСИЙ КЫРГЫЗСКОЙ
РЕСПУБЛИКИ Айыпова Д.А.1, Бейшебаева Н.А.2, Узакбаев К.3, Калиев Р.Р.4 Email: Aiypova662@scientifictext.ru
'Айыпова Динара Аалыевна — научный сотрудник, отделение нефрологии, Национальный центр кардиологии и терапии им. Академика М. Миррахимова; 2Бейшебаева Насира Адылбековна — кандидат медицинских наук, заведующий отделением,
отделение нефрологии, Национальный центр охраны материнства и детства; 3Узакбаев Камчыбек — профессор, доктор медицинских наук, директор,
Национальный центр охраны материнства и детства; 4Калиев Рысбек Рысмамбетович — доктор медицинских наук, профессор,
кафедра факультетской терапии, Кыргызская государственная медицинская академия им. И.К. Ахунбаева, г. Бишкек, Кыргызская Республика
Аннотация: цель исследования: создать единый регистр нефробиопсий Кыргызской Республики (РНКР). Установить взаимосвязь между морфологическими и клиническими проявлениями гломерулопатий.
Материалы и методы: В исследование включено 237 больных, которым было выполнено исследование образцов почечной ткани, полученной прижизненной чрезкожной биопсией с 2015 по 2018 гг. Всем пациентам проводился комплекс общеклинических, биохимических, иммунологических, инструментальных и морфологических исследований.
Заключение: Наиболее распространенными вариантами поражения клубочков у взрослых были мембранный гломерулонефрит (MGN) (36,7%) и нефропатия иммуноглобулина A(IgAN) (30,2%), тогда как у детей доминировали IgA нефропатия (IgAB) и болезнь минимальных изменений (БМИ), которая отмечена у 20,4% и 19,3%, соответственно.
Ключевые слова: ключевые слова: заболеваемость, почечная биопсия, эпидемиология, регистр.
