CC BY
7
n. fl. ®OMma O. ro. yceHKO, -3. C. Eepe3H^bKoro. KHB: EiömoTeKa «3gopoB'a yKpa'HH», 2018. 354 c.
3. Aggarwal G., Peden C. J., Quiney N. F. Improving Outcomes in Emergency General Surgery Patients: What Evidence Is Out There. Anesth. Analg. 2017. Vol. 125, No. 4. P. 1403-1405.
DOI: https://doi.org/10.1213/ANE.0000000000002190
4. Asim M., Alkadi M. M., Asim H., Ghaffar A. Dehydration and volume depletion: How to handle the misconceptions. World J Nephrol. 2019. Vol. 21, No. 1. P. 23-32. DOI: https://doi.org/10.5527/wjn.v8.i1.23
5. Carlisle J. B. Risk prediction models for major surgery: composing a new tune. Anaesthesia. 2019. Vol. 74. P. 7-12. DOI: https://doi.org/10.1111/anae.14503
6. Croskerry P., Cosby K. S. Patient Safety in Emergency Medicine. Philadelphia: Lippincott-Williams &Wilkins, PA, USA, 2016. 1279 p.
7. Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany / G. Marx et al. Eur J Anaesthesiol. 2016. Vol. 33, No. 7. P. 488-521.
DOI: https://doi.org/10.1097/EJA.0000000000000447
8. Miller T. E., Myles P. P. Perioperative Fluid Therapy for Major Surgery. Anesthesiology. 2019. Vol. 130. P. 825-832.
DOI: https://doi.org/10.1097/ALN.0000000000002603
9. Murray D. Improving outcomes following emergency laparotomy. Anaesthesia. 2014. Vol. 69. P. 300305. DOI: https://doi.org/10.1111/anae.12620
10. NELA Project Team. The Fifth Patient Report Of The National Emergency Laparotomy Audit. RCoA. London: UK, 2019. 59 p.
11. Patel N., Durland J., Makaryus A. N. Physiology, Cardiac Index. StatPearls. StatPearls Publishing; 2021. URL: https://www.ncbi.nlm.nih.gov/books/NBK539905/
12. Patel R., Cooper N., Paul Cramp P., Forrest K. Essential Guide to Acute Care. 3rd ed. Wiley-Blackwell, NJ, USA, 2020. 240 p.
13. Risk assessment tools validated for patients undergoing emergency laparotomy: a systematic review / C. M. Oliver et al. Br. Journal of Anaesthesia. 2015. Vol. 115, No. 6. P. 849-860.
DOI: https://doi.org/10.1093/bja/aev350
14. Tobias A., Ballard B. D., Mohiuddin S. S. Physiology, Water Balance. StatPearls. StatPearls Publishing; 2021. URL: https://www.ncbi.nlm.nih.gov/books/NBK541059/
15. Vivekanand K. H., Mohankumar K. Clinical Outcome of Emergency Laparotomy: Our Experience at tertiary care centre (A case series). Inter. Journal of Biomedical and Advance Research. 2015. Vol. 6, No. 10. P. 709-14.
CraTra Hagmm^a go pega^ii 05.03.2021
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UDC 616.89-008:616.8-009.836]-036-07 https://doi.org/10.26641/2307-0404.202L3.241966
Yu.V. Liashchenko, CLINICAL FEATURES OF SLEEP
LM Yuryeva DISTURBANCES IN ANXIETY DISORDERS
OF NEUROTIC AND ORGANIC GENESIS
Dnipro State Medical University V. Vernadsky str., 9, Dnipro, 49044, Ukraine flmnpoecbKuu dep^aenuu Medmnuu yuieepcumem eyn. B. Вeрнадсbкого, 9, flmnpo, 49044, YKpaina e-mail: [email protected]
Цитування: Медичт перспективы. 2021. Т. 26, № 3. С. 100-106 Cited: Medicniperspektivi. 2021;26(3):100-106
Key words: components of anxiety, neurotic disorders, sleep disorders, organic anxiety disorder Ключовi слова: компоненти тривоги, невротичнi розлади, порушення сну, органгчний тривожний розлад Ключевые слова: компоненты тревоги, невротические расстройства, нарушения сна, органическое тревожное расстройство
МЕДИЧН1ПЕРСПЕКТИВИ / MEDICNIPERSPEKTIVI
Abstract. Clinical features of sleep disturbances in anxiety disorders of neurotic and organic genesis. Liashchenko Yu.V., Yuryeva L.M. There is a bi-directional link between dyssomnia and psychological diseases. Sleep disorders can influence the severity of the underlying disease, complicate the process of treatment, and increase the risk of the recurrence further. Besides, there is an obvious dependence of the sleep disorder severity from the pathological anxiety. The aim of the research: to study clinical features and relationship of sleep disorders and anxiety in patients with anxiety disorders of neurotic and organic genesis. To achieve the objective, 120 patients with anxiety-depressive disorders, who were divided into 2 groups depending on the genesis of the disease were studied. The first group included patients with anxiety-depressive disorders, anxiety phobic disorder and generalized anxiety disorder. The second group included patients with emotionally labile and organic anxiety disorders. The research was done with the help of clinical-psychopathological method added with psychometric scales and with the method of statistical processing. According to the results, it was detected that the level of insomnia was reliably higher in patients with anxiety disorders of organic genesis than in the group of patients with neurotic disorders. After the analysis of the components of the pathological anxiety it was determined that the components of emotional discomfort and the assessment of the prospects of anxiety dominated in the group of neurotic genesis, but the asthenic and phobic components were more expressed in the group ofpatients with anxiety disorders of organic level. In addition, according to the results of the correlation analyses, it was determined the link of the degree of expression and the severity of insomnia. Understanding of the semantic character of the pathological anxiety and clinical display of sleeping disorders will give the possibility to create the relevant differential rehabilitation programs of the treatment of the patients with anxiety-depressive disorders with sleep disorders.
Реферат. Клшчш особливосп порушень сну при тривожних розладах невротичного та оргашчного генезу. Лященко Ю.В., Юр'ева Л.М. Мiж диссомтею та ncuxi4HUM захворюванням icnye двоспрямований зв'язок. Розлади сну можуть впливати на тяжккть nеребiгу основного захворювання, ускладнювати процес лiкування, а також тдвищувати ризик рецидиву в подальшому. Крiм того, кнуе чтка залежтсть тяжкостi порушень сну вiд патологiчноi тривоги. Мета до^дження - вивчення клiнiчних особливостей i взаемозв'язку порушень сну i тривоги у хворих на тривожш розлади невротичного й органiчного Тенезу. Для вирiшення поставлено'1' мети було проведено дослiдження 120 хворих з тривожно-депресивними розладами, як були розподiленi на двi групи залежно вiд генезу захворювання. У першу групу входили пацieнти з тривожно-депресивним розладом, тривожно-фобiчним розладом та генералiзованим тривожним розладом. Другу групу склали пащенти з оргатчним емоцшно-лабшьним та органiчним тривожним розладами. До^дження проводилося за допомогою клiнiко-психопатологiчного методу, доповненого психометричними шкалами, а також методу статистично'1' обробки. За результатами до^дження було виявлено, що в пацieнтiв з тривожними розладами органiчного рiвня вираженкть тсомни достовiрно вище порiвняно з групою хворих з невротичними розладами. Шсля проведення аналiзу компонентiв патологiчноi тривоги було встановлено, що в групi хворих невротичного генезу переважали компоненти емоцшного дискомфорту й тривожно'1' оцтки перспектив, а в груш хворих з тривожними розладами органiчного рiвня найбшьш вираженими були асте-нiчний та фобiчний компоненти тривоги. Також за результатами кореляцтного аналiзу був виявлений взаемо-зв'язок ступеня вираженостi компонентiв тривоги й тяжкостi тсомнП. Розумiння змктового характеру патологiчноi тривоги i miтчних проявiв розладiв сну дасть можливкть створити вiдповiднi диференцшоваш реабiлiтацiйнi програми л^вання хворих на тривожно-депресивт розлади з порушеннями сну.
Dyssomnia is one of the most common clinical manifestations correlating with the phenomenon of anxiety in neurotic disorders [5]. Studies from around the world show prevalence of sleep disturbances ranging from 1.6% to 56.0% [11].
A number of studies have examined the relationship between anxiety disorders and sleep disturbances, and the two-way relationship between them has been identified [10].
Insomnia is defined as a clinical syndrome that is characterised, on the one hand, by the presence of sleep disturbances in the form of problems with its onset, consolidation or quality, provided that these problems occur when a person has sufficient time for sleeping
and that they cause negative effects in the form of disturbances of daily activities of various kind [6].
In their turn, primary and secondary forms can also be highlighted in the group of psychogenic sleep disturbances. Insomnia, which occurs at the very beginning of neurotic decompensation, is considered to be primary, and insomnia, which is added to the already existing complex of neurotic disorders, is considered to be secondary. According to most authors, the disorders of the secondary psychogenic insomnia group are most widespread [7].
Collectively, present data demonstrate that insomnia is often a comorbid condition with anxiety
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and depression, and that sleep disturbances are more severe when such comorbidities are present [3, 9].
However, though many studies have been conducted in this area, most of them examined sleep disturbances in neurotic anxiety disorders. At the same time, in our opinion, dyssomnia in patients with anxiety disorders of organic genesis have not been sufficiently studied.
The aim of the study - examine the clinical features and the relationship between sleep disturbances and anxiety in patients with anxiety disorders of neurotic and organic genesis.
MATERIALS AND METHODS OF RESEARCH
To achieve the goal, 120 patients with anxiety disorders of various origins have been selected and divided into 2 groups depending on the level of the disease. The first group consisted of 38 (63.3%) patients with mixed anxiety-depressive disorder, 10 patients (16.7%) with phobic anxiety disorder, and 12 patients (20.0%) with generalised anxiety disorder. The second group consisted of 32 patients (53.3%) with organic emotionally labile disorder and 28 (46.7%) patients with organic anxiety disorder. The diagnosis has been determined in accordance with the ICD-10 criteria.
The research was conducted in accordance with the principles of bioethics set out in the WMA Declaration of Helsinki - "Ethical principles for medical research involving human subjects" and "Universal Declaration on Bioethics and Human Rights" (UNESCO).
The study has been conducted using clinical-psychopathological method, supplemented by the Insomnia Severity Index by Ch. Morin and the Integrative Anxiety Test (A.P. Bizyuk).
The Insomnia Severity Index makes it possible to determine the degree of insomnia intensity and to assess the intensity degree of its individual components [8].
Using Integrative Anxiety Test, the rate of trait and state anxiety can be estimated; also, its individual components can be analyzed, such as: emotional discomfort (ED), asthenic (AST) and phobic (PHOB) components, anxious evaluation of outcomes (EO) and social defense reactions (SD) [2].
The methods of descriptive and analytical biostatistics have been used for statistical processing of research material. Verification of compliance of the distribution of quantitative features with the normal law has been conducted using the Shapiro-Wilk test (SW-W). Considering mainly abnormal distribution of traits, non-parametric characteristics and criteria have been used: median (Me), interquartile range (25%; 75%) - 25 and 75 percentiles
respectively, Q1 and Q3 - the first and the third quartiles, respectively, to compare two independent samples - Mann-Whitney U test. The arithmetic mean and standard deviation - M (SD) have been used for normal distribution to describe the groups; and the Student's t test has been used to compare them. The assessment of statistical significance of relative indicators has been performed using the Pearson's chi-squared (x2) test. Spearman's rank correlation coefficient (rs) has been used to assess the relationship between traits. The critical value of the statistical significance level (p) for all kinds of analysis has been taken as <5% (p<0.05) [1, 4].
Statistical processing of the study results has been performed with the help of a personal computer using Microsoft Excel software (Microsoft Office 2016 Professional Plus, Open License 67528927), STATISTICA 6.1 (StatSoftInc., Serial No. AGAR909E415822FA).
RESULTS AND DISCUSSION
Among patients under study, women prevailed -101 female patients (84.2%) and 19 male patients (15.8%). This trend can be observed in both groups (p=0.803).
The age of patients ranges from 23 to 65 years and averaged 44.3 (12.4) years - M (SD). At the same time, in the group of patients with anxiety disorders of neurotic genesis (G1), young and middle aged persons predominated, the average age was 36.76 (9.95) years - M (SD), and in the group of patients with anxiety disorders of the organic genesis (G2) older patients predominated, the average age was 51.9 (9.73) years - M (SD).
When analyzing the features of sleep disturbances in both groups, the following results have been obtained (Insomnia Severity Index by Ch. Morin).
When assessing the indicators of difficulties with falling asleep, frequent and/or long awakening and performance decrement due to sleep deficit, no significant differences between the groups have been observed, and, in general, the indicators have been of a high level of severity.
The group of patients with anxiety disorders of organic genesis, has demonstrated the indicator of early morning awakening to be significantly (p<0.001) higher (Me - 3.0 points, interquartile range 2.5 -3.0 points) and correspond to the high level of severity in comparison with the group of neurotic patients (Me - 2.0 points, interquartile range 2.0 - 3.0 points), where this indicator have reached an average level.
The indicators of satisfaction with sleep in G2 patients (Me - 3.0 points, interquartile range 3.0 -3.0 points) and concern with poor sleep quality
(Me - 3.0 points, interquartile range 3.0 - 3.0 points) have been statistically significantly (p<0.001) higher than in G1 patients, whose satisfaction with sleep has been as follows: Me - 2.7 points, interquartile range 2.5 - 3.0 points, and concern with poor sleep quality, as follows: Me - 2.0 points, interquartile range 2,0 -3.0 points. At the same time, in general, these indicators in G2 patients has corresponded to the high severity degree, and in G1 patients, they have reached the average level.
The indicator of the decrease in the quality of life due to sleep deficit in G1 patients has been assessed as average (Me - 2.0 points, interquartile range 2.0 -3.0 points), and in G2 patients, it has been high (Me - 3.0 points, interquartile range 3.0 - 3.0 points). In this case, the differences between the groups are statistically significant (p<0.05).
In general, in both groups the indicators of the insomnia severity corresponded to the average severity. At the same time, the group of patients with anxiety disorders of organic genesis has demonstrated the indicator (Me - 20.0 points, interquartile range 18.0 - 21.0 points) to be significantly (p<0.001) higher than in the group with neurotic disorders (Me - 18.0 points, interquartile range 16.0 - 20.0 points).
As a result of our research, it was identified that in patients with anxiety disorders of organic genesis the indicator of insomnia severity was higher than in patients with neurotic disorders. Meanwhile the indicators of the early morning awakening, concern with bad dream and a decline of the quality of life in relation to bad dream were statistically significantly higher. We consider that these differences can be related to the duration of disease and the existence of the accompanying pathologies in a group of patients with anxiety disorders of organic genesis.
When studying the severity of anxiety and its individual components in both groups, the following results have been obtained (Integrative Anxiety Test A.P. Bizyuk).
The general indicator of state anxiety in G2 patients has been significantly (p - 0.014) higher than in G1 patients and has amounted to Me -9.0 stanine, interquartile range 8.0 - 9.0 stanine. G1 patients have demonstrated the indicator to be as such: Me - 8.0 stanine with interquartile range 8.0 -9.0 stanine. In general, both groups have demonstrated the component to be at a high level.
When assessing the individual components of state anxiety, it has been found that emotional discomfort in the group of neurotic patients is statistically significantly (p<0.001) higher (Me -8.0 stanine, interquartile range 8.0 - 9.0 stanine)
than in the group of patients with anxiety disorders of organic genesis (Me - 8.0 stanine, interquartile range 7.5 - 8.0 stanine). Moreover, both groups have demonstrated the component to be at a high level.
It should be noted that the group of patients with anxiety disorders of organic genesis has demonstrated the phobic component to be significantly (p -0.001) higher than in the group of patients with neurotic anxiety disorders and amounted to Me -8.0 stanine, interquartile range 7.0 - 9.0 stanine, and in G1 patients - to Me - 7.0 stanine, interquartile range 7.0 - 9.0 stanine. The phobic component of state anxiety has had a high degree of intensity in both groups.
The asthenic component in G2 patients (Me - 9.0 stanine, interquartile range 8.0 - 9.0 stanine) is higher in comparison with G1 patients (Me - 8.0 stanine, interquartile range 8.0 - 9.0 stanine) and is assessed as high. These differences tend to be statistically significant (p - 0.052).
The component of anxious evaluation of outcomes in both groups has been high, and social defense reactions have reached an average level. In addition, both indicators in the groups have been approximately the same.
When analysing trait anxiety, it has been found that this indicator is significantly (p<0.001) higher in G2 patients (Me - 7.0 stanine, interquartile range 5.0 - 7.0 stanine) than in G2 patients (Me -5.0 stanine, interquartile range 5.0 - 6.0 stanine) and has been assessed as average in both groups.
Statistically significant differences (p<0.001) were revealed between the groups in the following components: asthenic and phobic components, social defense reactions.
The asthenic component in G1 patients has been lower (Me - 7.0 stanine, interquartile range 6.0 - 7.0 stanine) and assessed as a tendency to the high level of severity, in comparison with G2 patients, where it has made up Me - 7.5 stanine and interquartile range 7.0 -8.0 stanine and pointed to a high level of severity.
In the group of patients with anxiety disorders of organic genesis, the phobic component has made up Me - 7.0 stanine and the interquartile range of 7.0 - 7.0 stanine and has been assessed as average, and in the group of neurotic patients, the indicator has been lower and has made up Me - 4.0 stanine and the interquartile range 1.0 - 6.0 stanine, which corresponds to a low level of severity.
The values of social defense reactions in G1 patients have been lower (Me - 2.0 stanine, the interquartile range 1.0 - 4.0 stanine) than in G2 patients - Me - 4.0 stanine, the interquartile range
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4.0 - 4.0 stanine. In general, in both groups the indicator has been assessed as low.
Components of anxious evaluation of outcomes assessment and emotional discomfort of the indicator of trait anxiety in both groups have been approximately the same, and no statistically significant differences have been found.
Thus, it was determined that a higher degree of expression of the indicators of state and trait anxiety was noted in a group of patients with anxiety disorders of organic genesis. All differences were
statistically significant. In this group of patients, the asthenic and phobia components dominated as in a structure of state and trait anxiety in comparison with the group of neurological genesis.
The results give the understanding of informative manner of pathological anxiety in patients with anxiety disorders of different genesis, and the possibility of more differential approach in the treatment of these disorders.
The quantitative average indicators of the insomnia severity, state and trait anxiety are shown in Figure.
Quantitative average indicators of insomnia severity the Insomnia Severity Index by Ch. Morin (in points), state and trait anxiety ITT by A.P. Bizyuk (in stanines) in the groups
The relationship between the indicators of the severity of the components of state and trait anxiety and indicators of the severity of insomnia has been established based on the correlation analysis results (Table).
The indicators of state and trait anxiety correlate with the severity of insomnia; the statistically significant relationships have been identified, most of them are of average level. Therefore, when the
level of anxiety increases, the severity of insomnia increases as well, and vice versa.
According to the results obtained, we can say that the sleep disorders and pathological anxiety can mutually complicate the course of each other and deteriorate the quality of patient's life. Consequently it is very important to pay a special attention to the correlation of the sleep disorders during the treatment of anxiety disorders of different genesis.
Correlation between the indicators of the severity of the components of state and trait anxiety and indicators of the severity of insomnia (Spearman's rank correlation coefficient rs)
Difficulties Frequent Early Satisfaction with sleep Performance Decrease in the quality of life due to sleep deficit Preoccupation Severity
Indicator with falling and/or long morning decrement due with poor of
asleep awakening awakening to sleep deficit sleep quality insomnia
IAT ED 0.042 0.007 -0.09 -0.053 0.202* -0.009 -0.212* -0.026
IAT AST 0.143 0.054 0.294* 0.215* 0.29* 0.291* 0.214* 0.324*
IAT PHOB 0.008 0.195* 0.279* 0.324* 0.238* 0.257* 0.291* 0.341*
IAT EO 0.027 0.096 0.135 0.195* 0.258* 0.212* 0.178 0.223*
IAT SD -0.037 0.083 0.253* 0.27* 0.173 0.179 0.20* 0.225*
IAT S-Anxiety 0.135 0.134 0.323* 0.329* 0.349* 0.413* 0.343* 0.433*
IAT ED -0.031 0.226* 0.176 0.162 0.326* 0.191* 0.083 0.249*
IAT AST 0.157 -0.045 0.384* 0.401* 0.232* 0.300* 0.359* 0.381*
IAT PHOB 0.174 0.139 0.406* 0.434* 0.208* 0.339* 0.512* 0.459*
IAT EO 0.061 0.213* 0.119 0.284* 0.277* 0.254* 0.154 0.262*
IAT SD 0.229* 0.135 0.274* 0.356* 0.247* 0.331* 0.463* 0.42*
IAT S-Anxiety 0.209* 0.159 0.359* 0.450* 0.390* 0.411* 0.437* 0.497*
Note. * - statistically significant correlation coefficients at the level of p<0.05.
CONCLUSIONS
1. As a result of our research, clinical features of the sleep disorders and pathological anxiety in patients with anxiety disorders of organic genesis and neurological genesis were detected. The bidirectional relationship between the sleep disorder and anxiety was also researched and approved.
2. The results on the clinical features of the sleep disorders, state and trait anxiety can be the basis for the creation of differential selection of psychopharmacological and psychotherapy strategy of the treatment.
Conflict of interests. The authors declare no conflict of interest.
REFERENCES
1. Antomonov MYu. [Mathematical processing and analysis of biomedical data]; 2017. p. 578. Russian.
2. Bizyuk AP, Wasserman LI, Iovlev BV. [Application of the integrative test of anxiety]. Sankt-Peterburg: NIPNI; 2005. p. 22. Russian.
3. Pertseva TO, Kuyumchyan MS, Yurieva LM, Dukelsky OO. [Diagnosis, therapy and rehabilitation of persons who have suffered psychosocial stress and patients with depression in primary health care institutions (textbook)]. Dnipro; 2018. p. 170. Ukrainian.
4. Ivchenko GI, Medvedev Yul. [Introduction to Mathematical Statistics. "Statistics knows everything" (study guide)]. URSS. 2017. p. 608. ISBN 978-5-97104535-9. Russian.
5. Karavaeva TA, Mikhailov VA, Vasileva AV, et al. A comparative study of the efficacy of personality-oriented (reconstructive) and cognitive-behavioral psy-
chotherapy in neurotic anxiety disorders with insomnia. Zhurnal Nevrologii i Psikhiatrii im. SS Korsakova. 2018;118(4):60-66. Russian. doi: https://doi.org/10.17116/jnevro20181184260
6. Yakupov EZ, Troshina YV. [Anxiety, insomnia, depression - in conjunction with or opposite to functional disorders]. Zhurnal Nevrologii i Psikhiatrii im. SS Korsakova. 2016;116(5):119. Russian. doi: https://doi.org/10.17116/jnevro201611651119-124
7. Yastrebova VV, Yastrebov DV. Sleep disorders in anxiety disorders: clinical aspect and therapy. Consilium Medicum. 2016;18(2):117-23. Russian. doi: https://doi.org/10.26442/2075-1753_2016.2.117-123
8. Bastien CH, Valli res A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2:297-307. doi: https://doi.org/10.1016/S1389-9457(00)00065-4
21/ TOM XXVI/ 3
105
9. Bélanger L, Harvey AG, Fortier-Brochu É, et al. Impact of Comorbid Anxiety and Depressive Disorders on Treatment Response to Cognitive Behavior Therapy for Insomnia. Journal of Consulting and Clinical Psychology. 2016;84(8):659-67.
doi: https://doi.org/10.1037/ccp0000084
10. Baglioni C, Nanovska S, Regen W, Spiegelhalder, et al. Sleep and mental disorders: A meta- analysis of
polysomnography research. Psychol Bull. 2016;142(9):969-90. DOI: https://doi.org/10.1037/bul0000053
11. Stickley A, Leinsalu M, DeVylder JE, et al. Sleep problems and depression among 237 023 community-dwelling adults in 46 low- and middle-income countries. Scientific reports. 2019;9:12011. doi: https://doi.org/10.1038/s41598-019-48334-7
СПИСОК Л1ТЕРАТУРИ
1. Антомонов М. Ю. Математическая обработка и анализ биомедицинских данных. Киев: Мединформ,
2017. 578с.
2. Бизюк А. П., Вассерман Л. И., Иовлев Б. В. Применение интегративного теста тревожности. Санкт-Петербург: НИПНИ, 2005. 22 с.
3. Ддагностика, терап1я та реабштац1я оаб, що перенесли психосотальш стреси та хворих на депресп в медичних установах, що надають первинну медичну допомогу: навч. поаб. / Т. О. Перцева та т. Дншро, 2018. 170 с.
4. Ивченко Г. И., Медведев Ю. И. Введение в математическую статистику. «Статистика знает все»: учеб. пособ. URSS. 2017. 2-е изд. 608 с. ISBN 978-59710-4535-9
5. Сравнительное исследование эффективности личностно-ориентированной (реконструктивной) и когнитивно-поведенческой психотерапии при тревожных расстройствах невротического уровня с инсомнией / Т. А. Караваева и др. Журнал неврологии и психиатрии им. С. С. Корсакова. Спец. выпуск.
2018. Т. 118, № 4. С. 60-66.
DOI: https://doi.org/10.17116/jnevro20181184260
6. Якупов Э. З., Трошина Ю. В. Тревога, депрессия и инсомния - единство или автономность функциональных расстройств. Журнал неврологии и
психиатрии им. С. С. Корсакова. 2016. Т. 116 , № 5. С. 119-124. DOI: 10.17116/jnevro201611651119-124
7. Ястребова В. В., Ястребов Д. В. Инсомни-ческие нарушения при тревожных расстройствах: клиника и терапия. Consilium Medicum. 2016. Т. 18, № 2. С. 117-123.
DOI: https://doi.Org/10.26442/2075-1753_2016.2.117-123
8. Bastien CH, Valli res A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001. Vol. 2. P. 297-307. DOI: https://doi.org/10.1016/S1389-9457(00)00065-4
9. Impact of Comorbid Anxiety and Depressive Disorders on Treatment Response to Cognitive Behavior Therapy for Insomnia / L. Bélanger et al. Journal of Consulting and Clinical Psychology. 2016. Vol. 84, No. 8. P. 659-667.
DOI: https://doi.org/10.1037/ccp0000084
10. Sleep and mental disorders: A meta- analysis of polysomnography research / C. Baglioni et al. Psychol Bull. 2016. Vol. 142, No. 9. P. 969-990. DOI: https://doi.org/10.1037/bul0000053
11. Sleep problems and depression among 237 023 community-dwelling adults in 46 low- and middle-income countries / A. Stickley et al. Scientific reports. 2019. Vol. 9. P. 12011.
DOI: https://doi.org/10.1038/s41598-019-48334-7
Стаття надшшла до редакцп 30.03.2021
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