CC BY
1DOI 10.24412/CL-37135-2023-1-7-7
CELLULAR MEMBRANE-DERIVED NANOVESICLES AS A VERSATILE DRUG DELIVERY SYSTEM FOR IMAGING-GUIDED CANCER THERAPY
YANG ZHANG AND GANG LIU
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, China
gangliu.cmitm@xmu.edu.cn
The development of smart nanoparticles that enable to circumvent biological barriers and transport cargoes to target sites in the body promises safer and more effective drug delivery. Since cell membrane-based nanovesicles have the characteristics of both nano-sized and cell-based drug delivery platforms, they are regarded as promising cancer targeted delivery tools for both endogenous and exogenous cargos. What is perhaps most fascinating about these cell membrane-based drug delivery systems is that the natural targeting ability of those producing cells makes the exogenous engineering of targeting moieties unnecessary. In our laboratory, a variety of bio-inspired nano-biomaterials, such as virus-like nanoparticles and ferritin nanocages, have been studied for drug delivery, cell labeling, and gene therapy. A number of hybrid nanoparticles containing synthetic and biological components have been utilized for achieving sustained release and target-specific delivery. We are particularly interested in cell membrane-based nanoparticles containing bioactive molecules useful for therapeutic and imaging applications in cancer theranostics. In this presentation, an innovative biomimetic nanoparticle platform for delivering therapeutic anticancer agents and imaging-guided cancer therapy will be introduced. In addition, the major hurdles in the clinical translation of cell membrane-based delivery systems will be discussed.
Figure 1: The functional proteins can be anchored on the cell surface via genetic engineering tactics for various application prospects including cancer immunotherapy, vaccine delivery, virus/bacterial toxin capture, cancer oncolytic
virotherapy and chemotherapy drugs delivery.
ABSTRACT
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