Biomedical application of terahertz radiations in the coming
years
O. Cherkasova1'2
1-Institute of Automation and Electrometry, Siberian Branch of the Russian Academy of Sciences, 1 Academician Koptyug Ave., 630090 Novosibirsk, Russia 2- National Research Centre "Kurchatov Institute", 123182 Moscow, Russia
o.p.cherkasova@gmail.com
More than a century has passed since the discovery of terahertz (THz) radiation and the first experience in biology and medicine [1]. However, biomedical application of THz radiation is still an actively developing field of knowledge. Terahertz spectroscopy has shown great potential in biomedical research due to its unique features, such as the non-invasive and label-free identification of biological samples and medical imaging [2]. The report will provide a review of the known data and our own studies on THz spectroscopy of blood for diabetes [3], thyroid [4] and liver cancer [5] diagnosis. We will discuss applications of machine learning techniques to THz spectroscopy data, which will help to advance the method into clinical practice [6-8]. We will demonstrate the unique capabilities of THz radiation in the diagnosis of benign and malignant neoplasms of different nosology and localization [2,9], diabetic foot [10] and in ophthalmology [11]. We also highlight the biological effects of THz radiation and establishment of safe doses [12]. Further development of biomedical application of THz radiation is impossible without creation convenient and cheaper THz devices, super-resolution THz optical systems, THz waveguide. In conclusion, the most promising directions of further biomedical application of THz radiation are formulated.
The work was carried out within the framework of the state assignment of the IA&E. The work was partially supported within the state assignment of NRC "Kurchatov Institute".
[1] R. Singh, J. C. Bose and the German scientific community: scientific and political context, Current Science, vol. 96 (3), 419-422 (2009).
[2] O.A. Smolyanskaya, N.V. Chernomyrdin, A.A. Konovko, et al, Terahertz biophotonics as a tool for studies of dielectric and spectral properties of biological tissues and liquids, Progress in Quantum Electronics, vol. 62, 1-77 (2018).
[3] O.P. Cherkasova, M.M. Nazarov, A.A. Angeluts, A.P. Shkurinov, Analysis of blood plasma at terahertz frequencies, Optics and Spectroscopy, vol. 120 (1), 50-57 (2016).
[4] M.R. Konnikova, O.P. Cherkasova, et al, Malignant and benign thyroid nodule differentiation through the analysis of blood plasma with terahertz spectroscopy, Biomedical Optics Express, vol. 12 (2), 1020-1035 (2021).
[5] M.M. Nazarov, O.P. Cherkasova, et al, A Complex Study of the Peculiarities of Blood Serum Absorption of Rats with Experimental Liver Cancer, Optics and Spectroscopy, vol. 126 (6), 721-729 (2019).
[6] D. Vrazhnov, A. Knyazkova, et al, Analysis of Mouse Blood Serum in the Dynamics of U87 Glioblastoma by Terahertz Spectroscopy and Machine Learning, Appl. Sci., vol. 12, 10533 (2022).
[7] D. Vrazhnov, D.A. Ovchinnikova, et al, Terahertz Time-Domain Spectroscopy of Blood Serum for Differentiation of Glioblastoma and Traumatic Brain Injury, Appl. Sci., vol. 14, 2872 (2024).
[8] O. Cherkasova, D. Vrazhnov, et al, Terahertz Time-Domain Spectroscopy of Glioma Patient Blood Plasma: Diagnosis and Treatment, Appl. Sci., vol. 13, 5434 (2023).
[9] N.V. Chernomyrdin, G.R. Musina, et al, Terahertz technology in intraoperative neurodiagnostics: A review, Opto-Electronic Advances, vol. 6, 220071 (2023).
[10] G.G. Hernandez-Cardoso, S.C. Rojas-Landeros, M. Alfaro-Gomez, et al, Terahertz imaging for early screening of diabetic foot syndrome: A proof of concept, Sci. Rep. vol. 7, 42124 (2017).
[11] I. Ozheredov, M. Prokopchuk, M. Mischenko, et al, In vivo THz sensing of eye cornea, Laser Phys. Lett., 15 (5), 055601 (2018).
[12] O.P. Cherkasova, D.S. Serdyukov, E.F. Nemova, et al, Cellular effects of terahertz waves, Journal of Biomedical Optics, 26 (9), 090902 (2021).