CC BY
23
АБСТРАКТЫ
АКТУАЛЬНЫЕ ВОПРОСЫ ТРАНСПЛАНТОЛОГИИ В
НЕФРОЛОГИИ
Arterial Stiffness and Metabolic Syndrome Indices in Renal Transplantation Patients
purpose AND relevance: Although renal transplantation improves survival, cardiovascular morbidity and mortality still remain as
PARTICIPANTS: One hundred and forty nine kidney transplant recipients from our renal transplant outpatient clinic were enrolled into the study.
standard clinical (age, gender, duration of hemodialysis, post-transplant time), biochemical parameters. Anthropometric and body composition analyses were performed for all patients. Body compositions were analyzed by using the Body Composition Analyzer (Tanita BC- 420MA). PWv was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system.
RESuLTS: Patients were divided into two groups according to PWv levels. The frequency of patients with PWv > 7 m/s was higher in patients with new onset diabetes (55.9%), hyperuricemia (uric acid level > 7 mg/dl) (p:0.029, 0.05). Highercarotid-femoral PWv was significantly related with systolic (p:0.003) and diastolic blood pressure (p:0.002),
о
UJ
S
UJ
Q. Q.
со
Orhan Guliyev, Elgun Heziyev, Shelale Ismayilova, Arzu Ibishova, q,
Mehman Agayev щ
--§
Azerbaijan Medical Unixersity, Baku, Azerbaijan
UJ
a significant problem compared with nonrenal populations. In end stage
renal disease metabolic cardiovascular risk factors such as hypertension, hyperuricemia, obesity and diabetes mellitus have been confirmed to be ^ positively correlated with arterial stiffness. Arterial stiffness is an important characteristic of the arterial wall and can be assessed noninvasively by ^ the measurement of carotid-femoral pulse wave velocity (PWv). The aim of this study is to evaluate the risk factors for arterial stiffness in kidney transplant recipients.
d
METHODS AND ANALYSIS: All patients were evaluated for their
о
SCIENTIFIC-PRACTICAL MEDICAL JOURNAL
43
uric acid (p:0.0001) and fasting glucose (p: 0.02) levels. According to body composition analyses, muscle mass, visceral fat ratio and body weight were significantly higher in patients with PWv > 7 m/s (p<0.005). In patients with high PWv, sagittal abdominal diameters and waist P circumferences were significantly higher than patients with PWv < 7 m/s. When criteria for metabolic syndrome were assessed there were a significant increase in pulse wave velocity in patients with 0-1; 2-3; and 4-5criteria (p<0.01). S CONCLuSIONS: In post transplantation period, metabolic
syndrome indices as high blood pressure, hyperuricemia, hyperglycemia m and increased waist and hip circumferences are closely related with arterial stiffness. For cardiovascular risk reduction after renal ^ transplantation; blood pressure, serum glucose and uric acid levels should be under strict control.
KEYwORDS: Arterial Stiffness, Metabolic Syndrome, Renal Transplantation Patients.
о с
m Значение внедрения информационной системы | «Регистр доноров, реципиентов и пациентов, | рекомендованных к трансплантации органов» для m развития трансплантологии в Казахстане
со
с
m S
m
Доскалиев Ж.А., Жариков С.Н., Курмангужина М.Ш.
Учр. «Республиканский координационный центр по трансплантации», г.Астана, Казахстан
ЦЕЛЬ. В целях развития концепции посмертного донорства и соблюдения принципов справедливого распределения органов среди пациентов, в настоящее время формируется медицинская информационная система под рабочим названием «Регистр доноров, реципиентов и лиц, рекомендованных к трансплантации» (далее-Регистр).
ОПИСАНИЕ СУщЕСТВУющИХ МЕТОДИК. Практика стран с высокой трансплантологической активностью указывает на существование отдельных реестров для «листов ожидания», регистрации прижизненных и посмертных доноров, а также учета резуль-
44
НАУЧНО-ПРАКТИЧЕСКИЙ МЕДИЦИНСКИЙ ЖУРНАЛ
