CC BY
40STH MULTIDISCIPLINARY INTERNATIONAL
Conference of Biological Psychiatry
«Stress and Behavior»
Proceedings of the 9th International Multidisciplinary Conference «Stress and behavior» Saint-Petersburg, Russia, 16-19 May 2005 Editor: Allan V. Kalueff, PhD
CONFERENCE ABSTRACTS 1. PSYCHOPHARMACOLOGY
ANTIASTHENIC ACTION OF BEMITHYL AND PYRAZIDOL COMBINATION
IN DELAYED POSTTRAUMATIC PERIOD
I.V. Zarubina, F.N. Nurmanbetova,
E.F. Agajanian, P.D. Shabanov Department of Pharmacology, Military Medical Academy,
Saint-Petersburg, Russia
The brain injury is known to be the main reason in human disability due to traumatization of the nervous system. The long recovery period after brain injury is characterized by formation of psychopathological syndrome with asthenic features. Clinical investigations demonstrate, that the symptoms of delayed posttraumatic period are the same as in depression; both emotional and personality disorders are strengthening in such patients, and it suggests the search of new approaches for the pharmacological correction of posttraumatic cerebrasthenias. Forasmuch the neurodynamic disorders of hypoxic type are prevailed in pathogenesis of brain injury, we used bemithyl, a new antihypoxant of metabolic type, in combination with antidepressant pyrazidol to reduce asthenic symptoms in posttraumatic period in rats and humans.
Experimental investigations. Prior to the pharmacological experiments all rats were subdivided for two groups: with high (HR) and low resistance (LR) to hypoxia. The rats of both groups received pyrazidol (1 mg/kg) + bemithyl (25 mg/kg) i. p. for 20 days after mechanic brain injury. This combination of drugs harmonized behavioral reactions of phenotypically different rats (HR and LR) in terms of motor, explorative, emotional activity and anxiety level. All behavioral parameters in injured rats treated with the combination of drugs were the same as in control ones. Pyrazidol (1 mg/kg) + bemithyl (25 mg/kg) support metabolic status of the brain in injured rats on the level of intact animals. The optimal effect on the level of lipid peroxidation, superoxide dismutase activity and macroergs content was obtained in LR in comparison with HR rats.
Clinical investigations. 45 patients, males aged 18—50, with consequences of brain injury of moderate degree (asthenoneurotic, asthenovegetative syndromes preferably) were treated with combination of pyrazidol (50 mg per day) and bemithyl (250 mg per day) for 15 days. The psychological testing was assessed by the M.Lusher color scale of personal sense. The reduction of asthenic features, psychophysiological mobilization, moderate psychic activation with high orientation and adaptation velocity as well as the expediency and successfulness in actions were registered after course of therapy. Therefore, combination of pyrazidol and bemithyl can be estimated as an effective antiasthenic tool in posttraumatic period after mechanic brain injury.
Psychopharmacol. Biol. Narcol. 2005. Vol. 5, N 2. P. 891
Psyhopharmacology & biological narcology
ISSN 1606-8181
