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экспериментальная и клиническая гастроэнтерология | выпуск 117 | № 5 2015
информация | information
if CA was administrated into the stomach of animals and after a single administration or the course of CA.
A study was carried out on normotensive and hypertensive rats. BP was recorded telemetrically or by means of a tail cuff after single administration and 4 weeks course of Enerlit or Amberen (single dose was 16-25 mg of CA per kg of animal body weight), 12 rats were in each group. At the same time we determined the phases ofthe ovulatory cycle, behavioral responses
of animal and pH shift in blood after exercise. The state of women was assessed subjectively and objectively in controlled clinical trials after Amberen course (a single dose was of 4.3 mg of CA per kg) in the treatment for climacteric syndrome. We also measured the concentration of estradiol, FSH and LH in the peripheral blood.
All phenomena inherent in the action of Enerlit and Amberen were confirmed. However, we did not detect any rise of BP in experimental or clinical conditions.
121. Perspective probiotic sour-milk feeding-up to optimize the supply of infants
Noskova O. Y., Grigorovich M. S., Ardatskaya M. D.
Kirov State Medical Academy, the Russian Federation, e-mail: olgan-82@mail.ru
The purpose of the study: to compare the effectiveness of influence of bifidobacteria enriched with probiotic cultures and non-enriched products of sour-milk feeding-up on indices of functional activity of microbiota, conditions of mucosal immunity and resistance of infants' bodies.
Patients and methods. 103 healthy children 8-12 months old got sour-milk feeding-up within 30 days in 2 groups: group 1 (G1) got probiotic sour-milk products, n=70, group 2 (G2) got non-enriched children's kefir, n=33. The spectrum of SCFA in feces and the sIgA level in saliva were investigated in the dynamics, the index of frequency of acute diseases (I03) was evaluated within 6 months based on catamnesis.
The results. While evaluating the level of SCFA in feces of infants there have been found two types of metabolic profile: with 70 % it's «anaerobic» and with 30 % it's «aerobic». Taking in products of sour-milk feeding-up in
the 1G was marked with a more significant positive effect as restoration of parameters of acetic, propionic and butyric acids (p<0,05) up to reference meanings; a tendency to normalization of summative spectrum of SCFA and anaerobic index. There were no real changes of these indices in the 2G marked. Children of 11-12 months old who didn't get human milk but took in enriched sour-milk feeding-up showed an increase of sIgA level in the dynamics whereas it was decreased with the 2G (p<0,05). I03 evaluation revealed a higher level of resistance of the children of the 1G (taking in enriched sour-milk feeding-up) in regard to those in the 2G (p<0,05).
Conclusion. In comparison with traditional kefir, products enriched with bifidus bacteria make a more significant positive influence on indices of functional activity of microbiota and parameters of mucosal immunity and anti-infective resistance.
122. Specific pathological changes in the small bowel mucosa in patients with celiac disease
Pavlova J.13, Derovs A.2-3-4, Derova J.3-4, Pokrotnieks J.13
' Paul Stradins Clinical University Hospital, e-mail: katjapavlova@inbox.lv, 2Riga East Clinical University Hospital, 3Riga Stradins University, 4Latvian Maritime Medicine centre, Riga, Latvia
Aim of work. The aim of work was to evaluate the specific changes in the small intestine mucosa in patients with celiac disease using the capsule endoscopy (CE).
Materials and methods: data of celiac disease patients who underwent CE was evaluated. CE was performed in P. Stradins Clinical University Hospital and Latvian Maritime Medicine Centre for the period from 2006 till 2014. The original studyprotocol with more than 300 parameters (demographic, clinical, lab oratory and CE data) was fulfilled for each patient. All the data was entered into the database with consecutive statistical analysis using SPSS ver.16. Fol-lowingpathological changes in small intestine was analyzed for patients with celiac disease: pathological changes of the mucosae (erythematous, pale, edematous, granular, nodular, atrophic, mosaics), pathological changes of the villi and lesions of the mucous membrane (spots, plague, angioectasia, nodules, polyps, aphthae, erosions, ulcers).
Results. In total, 450 CE were performed during the period from 2006 to 2014. 375 CE were entered into the database. Out of them patients with celiac disease were — 16. The range of patient's age was from 15 to 45, with an average of (28.38±10.47) years. Positive statistically significant correlation was observed between presence of celiac disease and 1) atrophic mucosae: x2=7.843; p=0.005; 2) pathologic changes of villi (blunted, scalloped, swollen villi): x2=17.823; p<0.005; 3) presence of nodules in small intestine mucosae: x2=3.914; p=0.048.
Conclusions: 1. Celiac disease is characterized by mucosal atrophy, abnormal villous appearance (blunted, scalloped, swollen villi) and presence of nodules the small intestine mucosa. 2. There is a need for additional research in this area in order to improve knowledge about specific changes in the small intestine mucosa for patients with celiac disease.
123. Angiodysplasia in small intestine correlates with patients' age and specific complaints
Pavlova J.13, Derovs A.2'3'4, Derova J.3'4, Pokrotnieks J.13
' Paul Stradins Clinical University Hospital, e-mail: katjapavlova@inbox.lv, 2Riga East Clinical University Hospital, 3Riga Stradins University, Riga, 4Latvian Maritime Medicine centre, Riga, Latvia
The aim of work. The aim of work was to evaluate the in the small intestine and specific patients' demograph-possible correlation between angiodysplasia localized ic and clinical data.
тезисы 15-го юбилейного съезда ногр... | abstracts 15th anniversary congress "gssr".
Materials and methods. Angiodysplasia in the small intestine was detected by capsule endoscopy (CE). CE was performed in P. Stradins Clinical University Hospital and Latvian Maritime Medicine Centre during the period from 2006 till 2014. The special study protocol with more than 300 parameters (demographic, clinical, laboratory and CE data) was fulfilled for each patient. Patients were divided into three groups according to their age: 1 — up to 40 years; 2-40-60 years; 3 — older than 60 years. All the data was entered into the database with consecutive statistical analysis using SPSS ver.16.
Results. In total, 450 CE were performed and 375 CE were entered into the database during the period from 2006 to 2014. Angiodysplasia was found in 27 patients. The range of patient's age varied from 18 to 80 (mean 60.19±16.33). Positive statistically
significant correlation was observed between presence of angiodysplasia in the small intestine and patient's age: x2=40.137; p<0.001. Positive statistically significant correlation between the angiodysplasia in the small intestine and specific patient's complaints such as 1) fatigue and weakness (x2=10.241, p=0.001) and 2) abdominal pain (x2=9.257; p=0.002) was found.
Conclusions. 1. Presence of angiodysplasia in the small intestine correlates with patient's age; it is more common detected in older patients. 2. Complaints such as fatigue and weakness and abdominal pain are specific for patients with angiodysplasia in the small intestine. 3. Investigation of the small intestine using CE, to exclude angiodysplasia, is required for patients with the above mentioned symptoms, when these symptoms cannot be explained by other reasons.
124. Comparative evaluation of the severity of alcohol liver cirrhosis scales
Rodina A. S., Shubina M. E., Dudanova O. P., Neelova I. V. Petrozavodsk State University, Emergency Hospital, Petrozavodsk, Russia
Aim of the study: to compare the diagnostic value of ABIC, Meddrey index (MI) in the assessment of the severity of alcoholic liver cirrhosis (ALD) and prognosis of glucocorticosteroids (GCS) effectiveness.
Materials and methods. 30 patients (14 men and 16 women) with ALC Class B (n=13) and C (n=17) on the Child — Pugh, aged (47,14±6,82) years were examined. MI and ABIC were calculated. MI>32, ABIC>9 showed severe ALC and the need of gluco-corticosteroid treatment. Bilirubin reduction >25 % for the first week of treatment was a criterion for the GCS effectiveness.
Results. 22 (73.4 %) patients had MI>32, 12 (54.5 %) of them did not receive corticosteroids and survived, 10 (45.5 %) received corticosteroids. From 10 patients, receiving corticosteroids (MI=49.43±14.60), survived 6 (60.0 %) patients with MI=72.56±4.58 and 4 (40.0 %) patients with MI=81.81±0.75, who did
not respond to corticosteroids, died. There were no relationship between the duration of hospitalization, the class of gravity on the Child — Pugh and MI. All patients (n=10) with ABIC>9.0 («high risk») received corticosteroids, 6 (60 %) of them responded to therapy, the rest 4 (40 %) did not respond to therapy and died. The close correlation (r=0.7165) between the duration of hospitalization and the value of ABIC, between the Child — Pugh class and value ABIC was founded.
Conclusions. ABIC showed higher specificity compared with MI in the administration of corticosteroids in patients with ALC.
Not all patients with IM>32 require the appointment of GCS. All patients with ABIC>9.0 need glucocor-ticosteroid therapy. The absence of response to GCS therapy in high risk patients is associated with a poor outcome.
125. Hepatitis C caused liver cirrhosis complications correlation with the risk of exitus letalis
Rudaka I.1, Mjasnikova M.1, Derovs A.12
'Riga Stradins University,2Riga East Clinical University Hospital, Riga, Latvia, e-mail: aleksejs.derovs@gastroenterologs.lv
Aim. The aim of the study was to retrospectively analyze potential correlation of liver cirrhosis with the risk of exitus letalis.
Materials and methods. Patients with liver cirrhosis due to chronic hepatitis C were retrospectively analyzed. All the data was obtained from Riga East University hospital from the time period of 2011 to 2014. Original protocol and database was developed with consequently data statistical analysis using SPSS ver. 20.0.
Results. 154 cirrhosis cases were enrolled in the study. Most of the patients were male — 92 (60 %). Age was ranging from 25 to 83 years (mean 53±13). 20 (24.1 %) patients with chronic hepatitis C were diagnosed for the first time, but 134 (75.9 %) — previously. From previously diagnosed, in 63 cases (47 %) duration of infection was known. At the time of hospitalization most of the patients (145 or 94 %) had liver cirrhosis
complications. Most frequent complications was portal hypertension — 94 %, which manifested with ascites — 72 %, esophageal varices (71 %), esophageal vein bleeding (40 %), portal vein thrombosis (6 %). Portal hypertension is followed by hepatic encephalopathy (25 %), hepatocellular carcinoma (14 %), hepatorenal syndrome (12 %) and spontaneous bacterial peritonitis (3 %). During hospitalization 44 patients died from rapidly progressing severe liver complications. Statistically significant positive correlation was found between exitus letalis and: 1) hepatic encephalopathy (p<0.001), 2) spontaneous bacterial peritonitis (p<0.001), 3) hepatorenal syndrome (p<0.001). Among other complications and exitus letalis significant correlation was not found.
Conclusions. Patients with complications such as hepatic encephalopathy, spontaneous bacterial peritonitis and hepatorenal syndrome, have a higher exitus letalis risk.
