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JQY|< ) JOURNAL OF CLINICAL MEDICINE OF KAZAKHSTAN Original Article
(E-ISSN 2313-1519)
Analysis of Publications on Acinetobacter: A Scopus Database Search Study
Emine Kübra Dindar Demiray1, Serpil Oguz Mizrakfi2, Sevil Alkan3
'Infectious Diseases and Clinical Microbiology Department, Bitlis State Hospital, Bitlis, Turkey 2Infectious Diseases and Clinical Microbiology Department, Özel Lara Anadolu Hospital, Antalya, Turkey 3Infectious Disease Department, Faculty of Medicine, Qanakkale Onsekiz Mart University, Canakkale,
Abstract
Aim: We aimed to review the global literature on Acinetobacter, which is a global health problem, and identify and characterize the publications to direct scientific studies.
Material and methods: We conducted a bibliometric analysis by searching the Elsevier' Scopus database. This database is one of the biggest international bibliometric database. We searched original research articles from this database using the keywords "Acinetobacter" or "Acinetobacter spp." and "Article" since July 05, 2021. We carried out detailed analysis to identify the characteristics of articles by using the bibliometric data analysis technique. The articles were analyzed due to the following characteristics: the country of origin, authors' names and affiliations, year of publication, content, number of citations and impact factor.
Results: The total number of publication on Acinetobacter were 35587 and the first publication was published in the year 1974. 30074 of these studies were research articles. Only research articles were evaluated in our study. There was a rapid increase in the number of articles after the year 2000 and the number of articles did not decrease until 2020 over the years. There was a decrease in the number of published articles in the year 2020. The majority of the articles (n=26862, 89.31%) were written in the English language. Chinese was the second most preferred language. The most scientifically productive countries on Acinetobacter literature were the United States, China and India. Ronald N Jones (n=174) from the USA and Harald Seifert (n=114) from Germany were the most productive authors on Acinetobacter research.
Conclusion: As a result, both the number of articles on Acinetobacter and the number of citations were quite high. Since the Acinetobacter genus is one of the most important pathogens in hospital infections, it seems that researchers will continue to work on this topic.
Key words: Acinetobacter, bibliometric analysis, Scopus
Received: 2021-07-16. Accepted: 2021-09-10
© ®
This work is licensed under a Creative Commons Attribution 4.0 international License
J Clin Med Kaz 2021; 18(5):44-48
Corresponding author: Emine Kübra Dindar Demiray. E-mail: e.kubradindar@hotmail.com; ORCID: 0000-0001-6459-7182
Introduction
Acinetobacter genus is Gram-negative, double or chained cocci or coccobacilli, non-spore-forming, sometimes encapsulated, aerobic, oxidase-negative, catalase-positive bacteria [1,2]. There are difficulties in treatment, especially because they have multiple antibiotic resistance and cause hospital infections, especially in intensive care units, globally. It has been shown that there are 12 different genomic types in its taxonomic classification. There are 49 species in the genus Acinetobacter. The clinically important species are A. calcoaceticus- A. baumannii (genomic
strain 2), Acinetobacter nosocomial (genomic strain 13TU), Acinetobacter pittii (genomic strain 3), and A. calcoaceticus (genomic strain 1), which are clinically important species [2,3]. A.baumannii complex (ABC) cannot be distinguished biochemically. Acinetobacter spp. is the most common cause especially in hospital-acquired pneumonia and bloodstream infections and their antibiotic resistances rates increase over the years (41%, 36%) [1-5].
Although Acinetobacter species are generally considered as pathogens with low virulence, that group bacteria have multiple virulence factors. It emerges as
an opportunistic pathogen that causes nosocomial infections with severe clinical manifestations, especially in patients with underlying disease and various risk factors [6]. Factors such as prolonged use of antibiotics, prolonged hospitalization in the hospital and especially in the intensive care unit, long-term use of medical equipment such as catheters and implants, being connected to a ventilator, cardio-pulmonary disease, extensive burns, change in consciousness and immune system deficiencies are related attributable risk factors for Acinetobacter infections development. Among Acinetobacter species, A. baumannii are known as the most virulent species. Multivariate analyzes revealed that the mortality of A. baumannii infections is nine times higher than infections caused by other species [6,7]. A. baumannii is at the top of the list of 'resistant bacteria that urgently require new antibiotic discovery' due to the increasing resistance rates published by the World Health Organization in the year 2018 [8]. Due to the antimicrobial resistance problem, studies to elucidate the virulence factors and antibiotic resistance mechanisms of A. baumannii should continue without slowing down in order to treat Acinetobacter infections. It should not be forgotten that researches on the inhibition of virulence factors with different methods, especially molecular methods, new applications that can be an alternative to antibiotic treatment, researches to be carried out for the development of efflux pump inhibitors and antibiofilm agents are very valuable in terms of the control of infections and public health worldwide [9].
We aimed to review the world literature on Acinetobacter, which is a global health problem, and identify and characterize the publications to direct scientific studies. To our knowledge, our study is the first bibliometric research in the field of Acinetobacter by using the Scopus database.
Material and methods Research model
In this study, bibliometric analysis method was used as a research model, which is one of the qualitative research method [10]. With this method, studies on a subject can be analyzed mathematically on the axis of various research parameters, including publication years, general characteristics, authors and institutions, keywords, funding institutions, citations, methods and samples [10].
The data of the study were obtained using the Elsevier Scopus bibliometric database, which is one of the main the international databases. This database, providing access to articles and references contained in these articles, allows it to search both forward and backward in time [10]. We searched original research articles from this database using the keywords "Acinetobacter" or "Acinetobacter spp." and "Article" since July 05, 2021. Duplications were included in the study only once. The obtained data were analyzed in the Excel file created by the researcher.
Canakkale Onsekiz Mart University's online library and digital resources were used to access information.
Data analysis
We carried out detailed analysis to identify the characteristics of articles by using the bibliometric data analysis technique. The articles were analyzed due to the following characteristics: the country of origin, authors' names and affiliations, year of publication, content, number of citations and impact factor. Also statistical analyzes (frequency and percentage) were performed to analyse the publications by using Statistical Package for the Social Sciences (SPSS) for Windows Version 23.0 software
(SPSS Inc., Chicago, IL, USA). Data were reported as mean ± standard deviation values, number and percentage. Descriptive statistics were used in the statistical evaluation.
Ethics committee
The study complied with the Helsinki Declaration, which was revised in 2013. Ethics committee approval is not required as there is no human or animal research.
Results
It was determined that there were 35587 publications on Acinetobacter topic and the first publication was published in the year 1974. 30074 of these studies were research articles. Only research articles were included to our study.
The greatest number of articles published in the last 20 years period from 2000 to 2020 and the number of articles did not decrease since 2020. In 2020, there was a decrease in the number of published articles (Figure 1).
Figure 1 - Number of published articles by years.
Documents by year
3500 3000 2500
I 2000
E
g 1500 O
1000 500
1947 19S4 1961 1968 197S 1982 1989 1996 2003 2010 2017 2024 Year
The most scientifically productive countries on Acinetobacter literature were the United States (USA), China and India. Turkey was in 9th place. The countrywide contribution of the articles is shown in Table 1.
The countrywide contribution of the articles (n=30074).
Country Number of publications Percentage by total number of publications
USA 5049 16.78
China 4559 15.15
India 2218 7.37
United Kingdom 1529 5.08
Germany 1410 4.68
France 1306 4.34
Japan 1236 4.10
Spain 1060 3.52
Turkey 1034 3.43
South Korea 985 3.27
The majority of the articles (n=26862, 89.31%) were written in English language. Chinese was the second most preferred language. 12503 (41.57%) of the articles were published in open access (AE) (Open Access) journals. Ranking of institutions according to the number of contributions to research given in Table 2. The institution with the highest number of contributors is Ministry of Education China (n=363). China-based institutions were in the first two places among the institutions with the highest number of publications.
Table 2
The list of top 15 institutions contributing the Acinetobacter literature (n=30074).
The List of Top 10 Journals Contributing the Acinetobacter Literature (n=30074).
Institution n %
Ministry of Education China 363 1.20
Chinese Academy of Sciences 283 0.94
Inserm 179 0.59
Zhejiang University 178 0.59
Tel Aviv University 177 0.58
Mahidol University 175 0.58
Hospital Clinic Barcelona 175 0.58
Universidade de Sao Paulo - USP 168 0.55
National Taiwan University Hospital 168 0.55
CNRS Centre National de la Recherche Scientifique 165 0.54
Monash University 159 0.52
Tehran University of Medical Sciences 151 0.50
Russian Academy of Sciences 150 0.49
National Yang-Ming University Taiwan 145 0.48
The University of Queensland 141 0.46
Journals n % CiteScore 2020 SCImago Journal Rank
Antimicrobial Agents And Chemotherapy 874 2.90 9.1 2.070
Journal of Antimicrobial Chemotherapy 541 1.79 9.1 2.124
Plos One 465 1.54 5.3 0.990
Frontiers In Microbiology 400 1.33 7.3 1.701
Journal of Clinical Microbiology 396 1.31 9.4 2.349
International Journal of Antimicrobial Agents 323 1.07 12 1.454
Diagnostic Microbiology And Infectious Disease 306 1.01 4.6 1.027
Chemotherapy 282 0.93 3.7 0.539
American Journal Of Infection Control 279 0.92 4.2 1.004
Chinese Journal Of Infection And Chemotherapy 278 0.92 0.4 0.112
* SCImago Journal Rank: SCImago Journal Rank measures weighted citations received by the serial. Citation weighting depends on subject field and prestige (SJR) of the citing serial.
Figure 2 - Number publications according to journals contributing the most to the related literature on Acinetobacter,
Figure 3 - Documents by authors.
The List of Most Cited Publications on Acinetobacter.
Author, Year Document title Source Cited by
Magiorakos,2012 Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance Clinical Microbiology and Infection 4988
Boucher,2009 Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America Clinical Infectious Diseases 3277
Wisplinghoff,2004 Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study Clinical Infectious Diseases 3111
Ventola,2015 The antibiotic resistance crisis: Part 1: causes and threats P and T 1990
Vincent,2009 International study of the prevalence and outcomes of infection in intensive care units JAMA - Journal of the American Medical Association 1968
Gao,2013 Human infection with a novel avian-origin New England Journal of Medicine 1776
Zhang,2015 Comprehensive evaluation of antibiotics emission and fate in the river basins of China: Source analysis, multimedia modeling, and linkage to bacterial resistance Environmental Science and Technology 1649
Hammer,1999 Antimicrobial activity of essential oils and other plant extracts Journal of Applied Microbiology 1636
Hidron,2008 Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007 Infection Control and Hospital Epidemiology 1525
Tacconelli,2018 Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis The Lancet Infectious Diseases 1177
The list of the top 10 journals according to the number of publications on Acinetobacter given in Table 3 and Figure 2. The journal with the highest number of articles on Acinetobacter is Antimicrobial Agents and Chemotherapy (n=874).
Documents by authors are given in Figure 3. Ronald N Jones (n=174) from USA and Harald Seifert (n=114) from Germany were most productive authors on Acinetobacter releated publications (Figure 3).
Twelve of the articles were cited more than 1000 times, 38 of them more than 500 times, 155 of them more than 250 times, 1034 of them more than 100 times, among all the articles on Acinetobacter. The article written by Magiorakos was the most cited article (n=4988) on Acinetobacter
Discussion
Bibliometric analysis which is social science study area, has been started to use in medical area in recent years. As different researchers made this analysis on different medical topics, it became easier to give way to perspective for future studies [1116]. Pubmed, The Web of Science (WOS) and Scopus databases are mostly common databases mainly preferred in bibliometric analyses [11-16]. As Acinetobacter infections are common nosocomial pathogens all over the world and WHO reported it as an emerging pathogen we choose Acinetobacter keyword to highlight the importance of this topic and sought to give a bibliometric overview of the literature on Acinetobacter, by using Scopus database, which was used in previously published bibliometric studies. As a result of our study we detected the greatest number of articles published in the last 20 years period from 2000 to 2020. But there was a rapid decrease in the number of articles by the year 2020. This status may be relevant to the pandemic.
In only similar study from Turkey on Acinetobacter topic. In this study, scientific publications on Acinetobacter bacteremia were analyzed by using the Web of Science (WOS) database. This study was limited to Acinetobacter bacteremia [11]. Our study had wider range on Acinetobacter. And similarly to our study, number of publications on Acinetobacter topic have been increasing and growing rapidly in the past decade. In this study the first article was written in the year 1985 [11]. In our study first article was written in the year 1965. The reason for this can be interpreted as the concept of Acinetobacter may have been understood after about 20 years to cause bacteremia.
In a study from Iran, a bibliometric analysis was conducted with using WOS database and co-citation analysis was made with the "TI" tag using Ravar PreMap, UCINET 6.528.0.0, and Netdraw 1.0.0.0 programs [12]. "Seifert, Harald" from Germany was found as the most productive author on Acinetobacter topic. In our study Ronald N Jones (n=174) from USA and Harald Seifert (n=114) from Germany were the authors with most
publications on Acinetobacter. The reason for the difference may be the narrower distribution of the WOS database. Magiorakos et al was the most cited author in our study. But in Danesh et al.'s [12] study "Seifert, Harald * Higgins, Paul G" were the top cited authors. This was attributed to the fact that we did not use a similar database with our study.
When the studies on Acinetobacter are examined in terms of the publication language, it is seen that the English is the mostly preferred language [11,12]. Our study findings were similar. The majority of the articles (n=26862, 89.31%) were written in English language. Chinese was the second mostly preferred language. This situation shows that English is dominant in the literature. This finding shows that Acinetobacter topic has globally importance.
As mostly previously studies [11-17], our study showed that the majority of articles from USA. This may due to research findings and large number of researchers in USA. But the top cited article was published by authors from European Centre for Disease Prevention and Control team [18]. This may be due to the fact that there is a reputable scientific community in the area of Infectious Diseases. In addition, the most cited 3 articles were published in the Clinical Microbiology and Infection journal, and this may due to the fact that this journal with a high impact factor and it is one of the most respected journals in the area of Infectious Diseases.
As a result, both the number of articles on Acinetobacter and the number of citations are quite high. Since Acinetobacter genus is one of the most important pathogens in hospital infections, it seems that researchers will continue to work on this subject.
Limitations of the study
In this study single database used for research. So, we cannot say that the findings obtained in the research we conducted in a single database represent the total literature on Acinetobacter. As bibliometric databases only indexes the academic publications that it covers. International citation indexes include only academic publications indexed in the used database. So regional literature which don't listed in international citation indexes don't have international visibility. This is the second limitation of our study.
Disclosures: There is no conflict of interest for all authors.
Acknowledgements: None.
Funding: None.
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