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2Advances in wideband (0.3-30 MHz) laser optoacoustic
diagnostics
P. Subochev
Laboratory of ultrasound and optoacoustic diagnostics, Institute of Applied Physics RAS
pavel@ipfran. ru
Biomedical optoacoustic diagnostics combine the molecular specificity of optical methods with the depth and spatial resolution of ultrasound [1]. The angiographic capabilities of optoacoustic diagnostics - the ability to visualize blood vessels of various calibers - largely depend on the sensitivity and bandwidth of the ultrasound antennas used [2]. Recent advances in the development of wideband (0.3-30 MHz) highly sensitive (10 Pa) piezopolymer (PVDF-TrFE) ultrasound antennas [3] allow for superior quality angiographic imaging in both clinical and preclinical research. The presentation will cover biomedical applications related to the diagnosis and treatment of vascular abnormalities, focusing on the technological capabilities of high-resolution real-time optoacoustic imaging systems. The potential of noninvasive optoacoustic microangiography in revealing deep vascular remodeling of experimental tumors during radiation therapy [4], as well as the capabilities of clinical scanning optoacoustic angiography in diagnosing angiopathies [5], will be demonstrated. Challenges, limitations, and research directions will also be discussed, illustrating the potential of piezopolymer ultrasound detectors in clinical biomedical optoacoustic imaging of the future.
Healthy mouse Experimental tumor Antiangiogenic treatment
Figure 1: Laser optoacoustic angiography in clinical and preclinical research.
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[3] Y.H. Liu, A. Kurnikov, W. Li, P. Subochev, D. Razansky, Highly sensitive miniature needle PVDF-TrFE ultrasound sensor for optoacoustic microscopy, Advanced Photonics Nexus, 2(5), (2023).
[4] A. Orlova, K. Pavlova, A. Kurnikov, A. Maslennikova, M. Myagcheva, E. Zakharov, ... I. Turchin, P. Subochev, Noninvasive optoacoustic microangiography reveals dose and size dependency of radiation-induced deep tumor vasculature remodeling, Neoplasia, 26, 100778, (2022).
[5] S. Nemirova, A. Orlova, A. Kurnikov, Y. Litvinova, V. Kazakov, I. Ayvazyan, P. Subochev, Scanning optoacoustic angiography for assessing structural and functional alterations in superficial vasculature of patients with post-thrombotic syndrome: A pilot study, Photoacoustics, 100616, (2024).
