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13A COMPARATIVE STUDYON THE PHARMACOKINETICS OFALISMA ORIENTALIS AND ITS COMPATIBILITY
Jiaxin Li1, SunYu1, Kaixin Liu1, Yuchi Zhang1, Xiaonan Liu1, Pengyang Yu1, Qijing Huang1, Pengling Ge *
IDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China; Corresponding authors: Pengling Ge, Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China; E-mail: [email protected]
Abstract Rhizoma Alismatis is the composition of the treatment of type E diabetes experience of one of the three flavors of Citrus grandis,modern pharmacological indicate that it have fuction include diuretic, lowering blood pressure, lowering blood sugar, anti-atherosclerosis, immune regulation and so on.The results of the study on the pharmacokinetic process of the active ingredient in rat rats after administration of Citrobenzene and Alisma orientalis respectively showed that Alisma Ophiopogonjaponicuscouldincreaseitsactiveingredient,A-24-acetateabsorbsinthebodyandreducesitsplasmaclearance.
Key words Rhizoma Alismatis ; Alcohol A-24-Acetate ; Pharmacokinetics ; HPLC-MS/MS
Objective To study the pharmacokinetic differences of Alisma orientalis and Alisma orientalis in rats.
Materials and methods Twenty - four SD rats were randomly divided into two groups, name-
ly, Huaqizeren group and Alisma group.According to 1mL / 100g body weight were given to the flower flag Ze, Alisma water decoction,take blood by the orbital venous plexus about 0.5mL before administration and after administration 0,0.25,0.5,0.75,1,2,3,4,6,8,12,24,48 h,determination of Alcohol A-24-Acetate by Liquid Chromatography / Quadruple-Flying Time Series Liquid Chromatography after processing0
Results and discussion Compared with Alisma group, the curve of Alcohol A-24-acetate was still bimodal0 However, it was found that the first peak time (Tmax) of the A-24-acetate was prolonged and the peak concentration (Cmax) did not change significantly0 The results showed that the effect of the combination of Citizen Zygren on the concentration of A-24-acetate in the evening was not obvious0 However, AUC0-t increased significantly, the elimination rate CL decreased, and was statistically significant (P <0.05), indicating that the compatibility of Alisma alcohol A-24-acetate the first peak time to extend0 At the same time, plasma clearance rate decreased, extending its role in the body time.It can be concluded that the degree of absorption of Alcohol A-24-acetate in the Citro-blazuron group was higher than that in the Alisma orientalis group and the plasma clearance rate was decreased.
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[6] YIN Chun-ping, WU Ji-zhou.Advances in immunoregulation of Alisma orientalis and its active components [J]. Chinese Traditional Medicine, 2001, 32 (12): 1132-1133.
a ZHANG Rui-fang, WAN Jian-xin, XU Yan-fang, YOU Dan-yu, CUI Jiong, PAN Yang-bin.Effects of Alisma alcohol B on C3a-mediat-human renal tubular epithelial cell mesenchymal transdifferentiation [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine , 2012, 10: 1407-1412.
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THEPROSPECTS OF ANTI-PLATELETFUNCTION OF ASPIRIN
Jin Wang , Xue -Ying Yan*,Yan-Hua Zhu,Hui Su
Heilongjiang University of Chinese Medicine, P.R.China 150040; Corresponding author: Xue-YingYan, Address: Heping Road 24, Harbin 150040, School of Pharmacy, Heilongjiang University of Chinese Medicine, P.R.ChinaE-
mail:[email protected]
Abstract Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediatedatherothromboembolic eventsbyirreversibleinhibitionofplateletcyclooxygenase-1(COX-1).Although aspirin is still effective, alarge number ofpatients will stilloccur atheroscleroticthromboembolic events, Besides that about 10% of patientsdo notrespond toaspirin,this phenomenon is called"aspirin resistance ".In this paper,we discussthemech-anism of aspirin resistance with these factors involved in aspirin resistance, and then analyze the potential mechanism of antiplatelet function, and provide a potential theoretical basis for promoting the formation of new antithrombotic drugs.
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Амурский медицинский журнал №4 (20) 2017
