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A CASE REPORT OF PITUITARY GIGANTISM OF 27-YEAR-OLD MALE PATIENT IN CHELYABINSK REGION OF RUSSIA
Anna Zheleznyakova1, Liliya Rostomyan2, Zhanna Belaya3
1City Clinical Hospital №3, Chelyabinsk, Russia; 2C.H.U. de Liège Domaine Universitaire du Sart-Tilman, Liege, Belgium; 3Endocrinology Research Centre, Moscow, Russia
Pituitary gigantism is a rare disorder. It refers to growth hormone (GH) excess that occurs before fusion of the epiphyseal growth plates. We report a 27-year-old male patient with a pituitary macroadenoma who underwent transsphenoidal surgery in 2004 at the age of 15 with the height up to 215 cm. He had history of visual impairment and severe headache. The patient's condition improved after the surgery but GH and insulin-like growth factor (IGF-I) levels did not normalize; as a consequence, he was referred for postoperative somatostatin analogue injection (30 mg per 28 days) with poor response. He continued to grow. In 2014 his height and body weight were approximately 235 cm and 142 kg, respectively, with a BMI of 25,7 kg/m2. The concentration of plasma GH and IGF-1 levels maintained a high level, which were 15.67 ng/mL and 408 ng/mL, respectively. Pituitary magnetic resonance imaging (MRI) revealed macroadenoma 33x28 x 2 3 mm without negative dynamic compared with 2008 year sizes 23x31x28 mm. The patient suffered from back pain, restriction of movement because of difference in length of the legs. Valgus deformation of knee joints was detected. For this reason he decided to undergo surgery in traumatology department in 11.2014 before he stabilized GH secretion. Osteosynthesis of the left hip with the extension apparatus, osteology of the femur in the distal third (cli-noid resection of the femur) were performed. Postoperative period was more then 3 months and patient walks with crutches till nowadays. He has edema of the left ankle experienced over a 1-year period and the huge strained left knee. In this consideration, he had a disability and impossibility to move. He needs more examinations in the National Research Center for Endocrinology. In conclusion all surgical manipulation should be provided after achieving the target level of GH and IGF-I secretion.
KEYWORDS: pituitary gigantism, case report. ★ ★ ★
A CASE OF ASSOCIATION OF TYPE 1 DIABETES MELLITUS AND PRECOCIOUS PUBERTY
Nadzeya Peskavaya2, Anzhalika Solntsava1, Natallya Kizevich2
12nd City Children's Hospital, Minsk, Belarus; 2Belarusian State Medical University, Minsk, Belarus
Introduction. The processes of intensive growth and puberty are regulated by growth hormone and sex hor-
mones, which are contrinsular. During the pubertal period the metabolic control is getting worse in the most of patients with type 1 diabetes mellitus (T1DM). One of the reasons of bad diabetes control at prepubertal children can be precocious puberty. Case report. A 4-year-old girl was diagnosed with T1DM 6 months ago. The daily dose of insulin was 0.5 units/kg. But during the last month glycemic control become worse and she was admitted to hospital for treatment correction. The daily dose of insulin increased to 1 units/kg and glucose levels according to continuous glucose monitoring system (CGMS) were very variable (from 2,9 to17,7 mmol/L). HbA1c level was 10,1%. On examination, girl was found to have Tanner stage 2 breast development. There was no axillary or pubic hair. Her height was above the 90th percentile (6 months ago it was above 50th percentile, familial target height - 50th percentile). Bone age was 4 years and 6 months (Greulich Pyele). There was no thyroid swelling, café au lait spots or any bone abnormality. Her investigations showed normal hemogram, liver and renal functions. Thyroid functions were normal. Her basal hormonal profile was as follows: LH 0,133 mIU/ml, FSH 1,67 mIU/ml. On ultrasonography, increase in ovarian volumes (bilateral) and uterus was found (uterus measured 35x7,8x12,5 mm, OS - 20x10 mm, OD - 27x15 mm). On the GnRH stimulation test, the peak LH and FSH levels were 10 times higher than basal levels, which was compatible with a diagnosis of central precocious puberty. Brain magnetic resonance imaging (MRI) was performed and the organic cause of precocious puberty was excluded. Conclusion. Association of T1DM with precocious puberty is rare. But in the case of an unexplained severe course of the disease, this reason must also be considered.
KEYWORDS: diabetes mellitus type 1, case report, precocious puberty.
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PITUITARY MACROADENOMA IN ADDISON'S DISEASE
C. Faria, D. Barbosa, A.S. Osório, E. Nobre, M.J. Bugalho
Hospital de Santa Maria, Lisbon, Portugal
Introduction. Long-standing primary failure of pituitary-dependent endocrine glands may lead to hyperplasia of the pituitary cells. Particularly, primary adrenal failure may predispose to corticotroph hyperplasia and in some patients to the development of corticotroph adenoma. We describe a rare case of a pituitary macroadenoma in a patient diagnosed with Addison's disease (AD). Case report. A 57-year-old female presented to the endocrinology outpatient department with complaints of weakness, dizziness and easy fatigability, nausea with occasional vomiting and darkening of the skin in the last 3 years. She also noticed progressive weight
PROBLEMS OF ENDOCRINOLOGY, 1, 2017, SUPPL. 2
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