Биотехнологии в медицине список научных статей
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The Use of Optogenetic and DREADDs Techniques: Applications to the Behavioral Pathology in Parkinson’s Disease (Review)
Recent advances in genetics have led to the development of novel optogenetic and chemogenetic tools that allow selective and remote interrogation of neural circuits using light-sensitive opsins and engineered G-protein-coupled receptors activated by inert druglike small molecules. These novel...
2019 / N. I. Novikov, E. S. Brazhnik, V. F. KichiginaScopusВАКESCI -
Molecular Markers of EBV- and HHV6-associated Mononucleosis
Epstein–Barr virus (EBV) and human herpesvirus type 6 (HHV6) are causative agents of infectious mononucleosis and can lead to the development of lymphoproliferative diseases. Means of radical therapy for this disease are yet to be found. Key transcripts involved in the pathogenesis can be used as...
2019 / E. N. Filatova, N. A. Sakharnov, D. I. Knyazev, T. N. Tsybusova, O. V. UtkinScopusВАКESCI -
Novel Technology of Modifying the Surface of Biodegradable Vascular Grafts with RGD Peptides: Effect on the Surface Structure and Physical and Mechanical Properties
The aim of the study was to assess the effectiveness of a new technology of modifying biodegradable small-diameter vascular grafts from polyhydroxybutyrate/valerate (PHBV) and polycaprolactone (PCL) with RGD peptides and its effect on the surface structure and physical and mechanical...
2019 / L. V. Antonova, V. N. Silnikov, T. V. Glushkova, L. S. Koroleva, I. Yu. Serpokrilova, V. V. Sevostyanova, E. O. Krivkina, E. A. Senokosova, A. V. Mironov, Yu. A. Kudryavtseva, L. S. BarbarashScopusВАКESCI -
Method of Pulmonary Arterial Pressure Correction during Pulmonectomy by Forming Intervascular Anastomoses (Experimental Study)
The aim of the study was to assess the possibility of reducing pulmonary arterial pressure by creating various types of intervascular anastomoses during left-sided pulmonectomy in the experiment. Materials and Methods. The experimental study was carried out on 102 laboratory animals (mini pigs)...
2019 / М. Т. NadyrovScopusВАКESCI -
Replacement of Osteochondral Defects of Major Joints in Experiment
The aim of the study was to develop a novel treatment method of knee osteochondral defects consisting in injecting platelet-rich plasma and crushed hyaline cartilage under a collagen membrane, and assess the technique in experiment. Materials and Methods. A prospective study was carried out on...
2019 / G. A. Airapetov, A. A. Vorotnikov, A. A. Venediktov, N. V. ZagorodnyScopusВАКESCI -
Ethical and Legal Aspects of Using Genome Editing Technologies in Medicine (Review)
According to many experts, the turning point in the development of genome editing technologies (GET) was 2012, when Feng Zhang and Jennifer Doudna independently proposed the adaptive bacterial immunity system CRISPR/Cas9 for editing the genome of living cells of eukaryotic organisms. Since then,...
2019 / M. N. Karagyaur, A. Yu. Efimenko, P. I. Makarevich, P. A. Vasiluev, Zh. A. Akopyan, E. V. Bryzgalina, V. A. TkachukScopusВАКESCI -
Biodegradable Magnesium Alloys as Promising Materials for Medical Applications (Review)
Non-degradable steel and titanium implants used to replace defects of the locomotor system or fabricate vascular stents provide maximum stability but have too many drawbacks. Currently, biodegradable magnesium alloys are considered as promising materials for creation of fixation devices in...
2019 / М. V. Kiselevsky, N. Yu. Anisimova, B. Е. Polotsky, N. S. Martynenko, Е. А. Lukyanova, S. М. Sitdikova, S. V. DobatkinScopusВАКESCI -
ИНСТРУМЕНТАЛЬНАЯ ДИАГНОСТИКА ДЕРЕВЬЕВ УЛИЧНОГО ОЗЕЛЕНЕНИЯ (НА ПРИМЕРЕ ЛИПЫ СЕРДЦЕЛИСТНОЙ (TILIA CORDATA))
В статье приведены данные по состоянию деревьев Липы сердцелистной, расположенных на улицах с высоким автотрафиком. Проанализировано влияние установления пристволовых кругов на состояние деревьев. Приведены данные исследований за 2015, 2017 гг. Показано ухудшение состояния обследованных деревьев,...
2018 / Кулакова С.А. -
ОЦЕНКА ФЕРМЕНТАТИВНОЙ АКТИВНОСТИ ХВОИ ЕЛИ СИБИРСКОЙ (PICEA OBOVATA) НА ТЕРРИТОРИИ ПАРКА ПОБЕДЫ Г. ПЕРМИ
В работе представлены результаты исследования активности каталазы и пероксидазы в хвое ели на участках с разной антропогенной нагрузкой в парке Победы Индустриального района г. Перми.
2017 / Гребенников А.А., Пименова Е.В. -
ИНСТРУМЕНТАЛЬНАЯ ДИАГНОСТИКА ДЕРЕВЬЕВ УЛИЧНОГО ОЗЕЛЕНЕНИЯ (НА ПРИМЕРЕ ЛИПЫ СЕРДЦЕЛИСТНОЙ (TILIA CORDATA))
В статье приведены данные по состоянию деревьев Липы сердцелистной, расположенных на улицах с высоким автотрафиком. Проанализировано влияние установления пристволовых кругов на состояние деревьев. Приведены данные исследований за 2015, 2017 гг. Показано ухудшение состояния обследованных деревьев,...
2017 / Кулакова С.А. -
Bioluminescent binding microassay using aptamers as biospecific elements
High specificity is an important requirement for an analytical system aimed at identifying a specific molecular target. Traditionally, antibodies, haptens and some other molecules are used for this purpose. Recently, aptamers were proposed as biospecific elements. Aptamers are short single-stranded ...
2019 / Frank Ludmila A., Bashmakova Eugenia E., Goncharova Natalia S., Krasitskaya Vasilisa V.WOSВАКRSCI -
Mechanical and permeability properties of thermoplastic starch composites reinforced with cellulose nanofiber for packaging applications
In this study, a facile, ecofriendly nanocomposite based on glycerol-plasticized thermoplastic potato starch (TPS) containing 0-4 wt.% cellulose nanofiber (CNF) from pineapple leaf was prepared by the solution casting technique. The nanocomposite films showed better mechanical properties compared...
2019 / Balakrishnan Preetha, Gopi Sreerag, Geethamma V.G., Thomas SabuWOSВАКRSCI -
Thermal and mechanical studies of biofiller/poly-3-hydroxybutyrate biocomposites
Biodegradable poly-3-hydroxybutyrate [P(3HB)] and birch wood flour (as filler) were used to prepare powdered blends and then pellets and granules. Pellets were produced by cold pressing of polymer and filler powders; granules were produced from the powders wetted with ethanol. The properties of the ...
2019 / Kiselev Evgeniy G., Kuzmin Andrew P., Nemtsev Ivan V.WOSВАКRSCI -
Design and application of slow-release pesticide formulations embedded in a biodegradable matrix based on poly(3-hydroxybutyrate)
The latest trend in agriculture is the development and application of environmentally friendly pesticides with targeted and controlled release of active ingredients embedded in biodegradable polymer bases. In this work, a series of experimental slow-release pesticide formulations was produced using ...
2019 / Prudnikova Svetlana V., Volova Tatiana G.WOSВАКRSCI -
Differentiation of BMSCs into nerve precursor cells on fiber-foam constructs for peripheral nerve tissue engineering
Bone marrow stem cells (BMSCs) are frequently used in nerve tissue engineering studies due to ease of their isolation and high potential for differentiation into nerve cells. A bilayer fiber-foam construct containing nanofibrous elements to house and guide BMSCs was designed as a model to study the ...
2018 / Dursun Usal Tugba, Yucel Deniz, Hasirci VasifWOSВАКRSCI -
Biocomposites based on degradable materials as biotechnological dermal equivalents
Hybrid tissue-engineered biosystems based on biodegradable polymers of microbiological origin bacterial cellulose (BC) and a copolymer of 3-hydroxybutyric and 4-hydroxybutyric acid P(3HB/4HB) were constructed using various methods: 1) the dried BC pellicles were soaked with a 2% P(3HB/4HB) solution ...
2018 / Shumilova Anna A., Shidlovsky Ivan P., Nikolaeva Elena D.WOSВАКRSCI -
Сonstruction and characteristics of experimental prototypes of ureteral stents on the basis of resorbable polyhydroxyalkanoates
Resorbable polyhydroxyalkanoates (PHAs) have been studied for the first time as a biomaterial for production of ureteral stents. For manufacturing of stents, the solutions of polyesters in chloroform were poured into silicone tubes. In the static version of the method, the tube was clamped at the...
2018 / Boyandin Anatoly N., Usenko Victoria V., Myltygashev Mirgen P.WOSВАКRSCI -
High performance in-situ composites developed from polypropylene/nylon 6/carbon nanotube blend systems
In the present work, microfibrillar composites (MFCs) based on polypropylene (PP) /Nylon 6 (NY) blends, along with multi walled carbon tubes (MWCNT) were prepared by melt processing technique. The blending of the fibre forming polymers was carried out in a twin screw extruder with varying...
2018 / Deeraj Battula Durga Siva, Jayanarayanan Karingamanna, Kuruvilla JosephWOSВАКRSCI -
Genetically modified coelenterazine-dependent luciferases as reporters for in vitro assay
Among the most important tasks of modern biotechnology is the development of new analytical techniques suitable for highly sensitive and specific detection of diagnostically important targets rapidly expanding their range with the progress in biomedical science. In this view, particular attention...
2017 / Frank Ludmila A., Bashmakova Eugenia E., Krasitskaya Vasilisa V., Kudryavtsev Alexander N.WOSВАКRSCI -
MICROBIAL BARRIER PROPERTY AND BLOOD COMPATIBILITY STUDIES OF ELECTROSPUN POLY-ƹ-CAPROLACTONE/ ZINC OXIDE NANOCOMPOSITE SCAFFOLDS
Electrospun poly-ƹ-caprolactone/zinc oxide (PCL/ZnO) nanocomposite scaffolds were reported for tissue engineering and wound healing applications. Wound coverage materials should have good barrier property against invading microbes. Since wound coverage materials and tissue engineering scaffolds are ...
2017 / Augustine Robin, Kalarikkal Nandakumar, Thomas SabuWOSВАКRSCI