Биологические науки список научных статей
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CASBench: a benchmarking set of proteins with annotated catalytic and allosteric sites in their structures
In recent years, the phenomenon of allostery has witnessed growing attention driven by a fundamental interest in new ways to regulate the functional properties of proteins, as well as the prospects of using allosteric sites as targets to design novel drugs with lower toxicity due to a higher...
2019 / Zlobin A., Suplatov D., Kopylov K., Švedas V.WOSScopusВАКPubMed -
Mauritian endemic medicinal plant extracts induce G2/M phase cell cycle arrest and growth inhibition of oesophageal squamous cell carcinoma in vitro
Terrestrial plants have contributed massively to the development of modern oncologic drugs. Despite the wide acceptance of Mauritian endemic flowering plants in traditional medicine, scientific evidence of their chemotherapeutic potential is lacking. This study aimed to evaluate the in vitro tumor...
2019 / Rummun N., Hughes R.E., Beesoo R., Li W.W., Aldulaimi O., Macleod K.G., Bahorun T., Carragher N.O., Kagansky A., Neergheen-Bhujun V.S.WOSScopusВАКPubMed -
“social life” of senescent cells: what is SASP and why study it?
Cellular senescence was first described as a failure of normal human cells to divide indefinitely in culture. Until recently, the emphasis in the study of cell senescence has been focused on the accompanying intracellular processes. The focus of the attention has been on the irreversible growth...
2018 / Borodkina A.V., Deryabin P.I., Giukova А.А., Nikolsky N.N.WOSScopusВАКPubMed -
The role of tal1 in hematopoiesis and leukemogenesis
TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms mesoderm in early embryogenesis, and regulates hematopoiesis in adult organisms. TAL1 is essential in...
2018 / Vagapova E.R., Spirin P.V., Lebedev T.D., Prassolov V.S.WOSScopusВАКPubMed -
A highly productive Cho cell line secreting human blood clotting factor IX
Hemophilia B patients suffer from an inherited blood-clotting defect and require regular administration of blood-clotting factor IX replacement therapy. Recombinant human factor IX produced in cultured CHO cells is nearly identical to natural, plasma-derived factor IX and is widely used in clinical ...
2018 / Kovnir S.V., Orlova N.A., Shakhparonov M.I., Skryabin K.G., Gabibov A.G., Vorobiev I.I.WOSScopusВАКPubMed -
Gene expression in the three-spined stickleback (Gasterosteus aculeatus) of marine and freshwater ecotypes
Three-spine stickleback (Gasterosteus aculeatus) is a well-known model organism that is routinely used to explore microevolution processes and speciation, and the number of studies related to this fish has been growing recently. The main reason for the increased interest is the processes of...
2018 / Rastorguev S.M., Nedoluzhko A.V., Gruzdeva N.M., Boulygina E.S., Tsygankova S.V., Oshchepkov D.Y., Mazur A.M., Prokhortchouk E.B., Skryabin K.G.WOSScopusВАКPubMed -
Influence of the linking order of fragments of HA2 and M2e of the influenza a virus to flagellin on the properties of recombinant proteins
The ectodomain of the M2 protein (M2e) and the conserved fragment of the second subunit of hemagglutinin (HA2) are promising candidates for broadly protective vaccines. In this paper, we report on the design of chimeric constructs with differing orders of linkage of four tandem copies of M2e and...
2018 / Stepanova L.A., Kotlyarov R.Y., Shuklina M.A., Blochina E.A., Sergeeva M.V., Potapchuk M.V., Kovaleva A.A., Ravin N.V., Tsybalova L.M.WOSScopusВАКPubMed -
Hypertension and cerebral microangiopathy (cerebral small vessel disease): genetic and epigenetic aspects of their relationship
Hypertension (HT) and its cerebral complications are extremely vexing medical and social problems. Despite the obvious association between hypertension and the clinical and neuroimaging features of cerebral microangiopathy (CMA) (also known as cerebral small vessel disease), the causal links...
2018 / Dobrynina L.A., Zabitova M.R., Kalashnikova L.A., Gnedovskaya E.V., Piradov M.A.WOSScopusВАКPubMed -
The Development and study of recombinant immunoglobulin a to hemagglutinins of the Influenza virus
We obtained recombinant variants of human antibody FI6 broadly specific to hemagglutinins of the influenza A virus. On the basis of a bi-promoter (CMV, hEF1-HTLV) vector, we developed genetic constructs for the expression of the heavy and light chains of the immunoglobulins of IgA1-, IgA2m1-, and...
2018 / Aliev T.K., Dement'Yeva I. G.; Russian Research Center For Molecular Diagnostics And Therapy, Toporova V.A., Argentova V.V., Pozdnyakova L. P.; Russian Research Center For Molecular Diagnostics And Therapy, Bokov M. N.; Russian Research Center For Molecular Diagnostics And Therapy, Votchitseva Yu. A., Dolgikh D.A., Varfolomeyev S.D., Sveshnikov P. G.; Russian Research Center For Molecular Diagnostics And Therapy, Kirpichnikov M.P.WOSScopusВАКPubMed -
Cognitive tagging of neurons: CREMediated genetic labeling and characterization of the cells involved in learning and memory
In this study, we describe use of Cre-mediated recombination to obtain a permanent genetic labeling of the brain neuronal networks activated during a new experience in animals. This method utilizes bitransgenic Fos-Cre-eGFP mice in which a green fluorescent protein is expressed upon...
2018 / Ivashkina O.I., Vorobyeva N.S., Gruzdeva A.M., Roshchina M.A., Toropova K.A., Anokhin K.V.WOSScopusВАКPubMed -
Reversible cyclic thermal inactivation of oligopeptidase b from Serratia proteamaculans
A unique property was found for oligopeptidase B from Serratia proteamaculans (PSP) as well as its mutants: they can undergo reversible thermal inactivation at 37°C, with activity being restored or even increased with respect to the initial one upon subsequent cooling. The process can be repeated...
2018 / Оvchinnikova M.V., Mikhailova A.G., Karlinsky D.M., Gorlenko V.А., Rumsh L.D.WOSScopusВАКPubMed -
Phylogenetic analysis and molecular typing of trichothecene-producing Fusarium fungi from Russian collections
We performed a three-locus phylogenetic analysis of Fusarium strains presumably capable of trichothecene production, which were deposited in the Russian national collections. The intraand interspecific polymorphism of partial sequences of the translation elongation factor 1 alpha (TEF1α) gene and...
2018 / Stakheev A.A., Samokhvalova L.V., Mikityuk O.D., Zavriev S.K.WOSScopusВАКPubMed -
High-throughput screening of biodiversity for antibiotic discovery
The increasing number of infections caused by antibiotic-resistant strains of pathogens challenges modern technologies of drug discovery. Combinatorial chemistry approaches are based on chemical libraries. They enable the creation of high-affinity low-molecular-weight ligands of the therapeutically ...
2018 / Terekhov S.S., Osterman I.A., Smirnov I.V.WOSScopusВАКPubMed -
Whole-genome sequencing of Russian Neisseria gonorrhoeae isolates related to ST 1407 genogroup
The whole-genome sequencing data of three N. gonorrhoeae strains isolated in the Russian Federation in 2015 are presented. According to the NG-MAST protocol, these strains are related to the globally spread ST 1407 genogroup. The analysis of their resistomes showed the absence of ermA/B/C/F genes...
2018 / Kubanov A.A., Runina A.V., Chestkov A.V., Kudryavtseva A.V., Pekov Y.A., Korvigo I.O., Deryabin D.G.WOSScopusВАКPubMed -
Influence of the activation of NMDA receptors on the resting membrane potential of the postsynaptic cell at the neuromuscular junction
Impaired function or insufficient expression of glutamate N-methyl-D-aspartate (NMDA) receptors underlies a number of brain pathologies; these receptors are, therefore, regarded as a pharmacological target for many neuroactive drugs. It was shown that in the CNS, this type of glutamate receptors...
2018 / Proskurina S.E., Petrov K.A., Nikolsky E.E.WOSScopusВАКPubMed -
Multifaced roles of the urokinase system in the regulation of stem cell niches
Proliferation, subsequent migration to the damaged area, differentiation into appropriate cell types, and/or secretion of biologically active molecules and extracellular vesicles are important processes that underlie the involvement of stem/progenitor cells in the repair and regeneration of tissues ...
2018 / Dergilev K.V., Stepanova V.V., Beloglazova I.B., Tsokolayev Z.I., Parfenova E.V.WOSScopusВАКPubMed -
Bacterial enzymes and antibiotic resistance
The resistance of microorganisms to antibiotics has been developing for more than 2 billion years and is widely distributed among various representatives of the microbiological world. Bacterial enzymes play a key role in the emergence of resistance. Classification of these enzymes is based on their ...
2018 / Egorov A.M., Ulyashova M.M., Rubtsova M. Yu.WOSScopusВАКPubMed -
“Noah’s Ark” project: interim results and outlook for classic collection development
The “Noah’s Ark” project, afoot at M.V. Lomonosov Moscow State University since 2015 and aimed at studying biodiversity, is the largest ongoing Russian project in life sciences. During its implementation, several hundred new species have been described; a comprehensive genetic and biochemical...
2018 / Kalyakin M.V., Seregin A.P., Solovchenko A.E., Kamenski P.A., Sadovnichiy V.A.WOSScopusВАКPubMed -
ASSESSMENT OF THE PARAMETERS OF ADAPTIVE CELL-MEDIATED IMMUNITY IN NAïVE COMMON MARMOSETS (CALLITHRIX JACCHUS)
Common marmosets are small New World primates that have been increasingly used in biomedical research. This report presents efficient protocols for assessment of the parameters of adaptive cell-mediated immunity in common marmosets, including the major subpopulations of lymphocytes and main markers ...
2018 / Gordeychuk I.V., Tukhvatulin A.I., Petkov S.P., Abakumov M.A., Gulyaev S.A., Tukhvatulina N.M., Gulyaeva T.V., Mikhaylov M.I., Logunov D.Y., Isaguliants M.G.WOSScopusВАКPubMed -
Variants of mitochondrial genome and risk of Multiple sclerosis development in Russians
For the first time in the history of ethnic Russians, an association analysis the development of multiple sclerosis (MS) was performed for the mitochondrial haplogroups H, J, K, and U, as well as for the individual mitochondrial DNA (mtDNA) polymorphisms discriminating these haplogroups (m.1719G >...
2018 / Kozin M.S., Kulakova O.G., Kiselev I.S., Balanovsky O.P., Boyko A.N., Favorova O.O.WOSScopusВАКPubMed