Фундаментальная медицина список научных статей
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Действие агониста TAAR1 RO 5263397 на дискинезию, вызываемую инъекцией α-NETA
В настоящее время собрано достаточно данных о роли следовых аминов (СА) как нейромодуляторов в центральной нервной системе млекопитающих. СА имеют структурное сходство с классическими биогенными аминами, а изменения их концентрации связаны с различными психическими расстройствами. В центральной...
2023 / Надежда Владимировна Полякова, Антон Юрьевич Александров, Вероника Михайловна Князева, Екатерина Павловна Виноградова, Елена Сергеевна Дмитриева, Людмила Николаевна Станкевич, Александр Алексеевич Александров
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Распределение супероксиддисмутазы-1 в мозге медоносной пчелы при действии электромагнитного излучения 2,4 ГГц
Одним из возможных путей негативного влияния высокочастотных электромагнитных излучений может быть окислительный стресс. В данной статье рассматривается влияние электромагнитного излучения Wi-Fi роутера 2,4 ГГц на цитоплазматический антиоксидантный фермент супероксиддисмутазу-1 в головном мозге...
2023 / Татьяна Геннадьевна Зачепило, Алиса Кирилловна Прибышина -
Сравнение жидкой и сухой сахарозной диеты в развитии модели метаболического синдрома у крыс
Для моделирования метаболического синдрома (МС) у крыс широко используется сахарозная модель, в которой сахароза добавляется в рацион животных в составе питьевой воды. Однако раствор сахарозы является благоприятной средой для развития микроорганизмов и плесени. Целью работы была проверка...
2023 / Юрий Алексеевич Филиппов, Андрей Валентинович Степанов, Александр Александрович Панов -
Development and Implementation of a Pilot Registry for Monitoring the Efficacy and Safety of Novel Therapies in Patients with Systemic Lupus Erythematosus
The therapeutic armamentarium in Systemic Lupus Erythematosus (SLE) is expanding with the introduction of novel biologic and small-molecule agents. Complementary to randomized controlled trials, registry-based studies are advantageous due to the inclusion of a wider range of patients from daily...
2020 / Christina Adamichou, Irini Flouri, Antonios Fanouriakis, Myrto Nikoloudaki, Dionysios Nikolopoulos, Argyro Repa, Kyriaki Boki, Katerina Chatzidionysiou, Alexandros Garyfallos, Dimitrios Boumpas, Prodromos Sidiropoulos, George Bertsias -
Regulation of microRNA in systemic lupus erythematosus: the role of miR-21 and miR-210
miRNAs are small non-coding RNA molecules that participate through silencing in post-transcriptional regulation of gene expression. Recent studies have highlighted the importance of microRNAs (miRNAs) as regulators of both the innate and the adaptive immune response. There are emerging data...
2020 / Maria Kourti, Maria Sokratous, Christina G. Katsiari -
Novel biomarkers for early targeted and individualized treatment in Juvenile Idiopathic Arthritis
Background: The programmed cell death protein-1 (PD-1) and its ligands (PD-L 1 and 2) suppress immune responses, thus promoting self-tolerance. Among the immunomodulatory cells, acting through the PD-1 pathway, are the B-regulatory cells (Bregs). The role of the PD-1 pathway in Juvenile Idiopathic...
2020 / Artemis Koutsonikoli, Anna Taparkou, Polyxeni Pratsidou-Gkertsi, Vassiliki Sgouropoulou, Theodoros Dimitroulas, Maria Trachana -
Immune checkpoint inhibitor-induced musculoskeletal manifestations. A multicentre prospective study
Background: Immune checkpoint inhibitors (ICI) are anti-cancer drugs that act by enhancing antitumour immunity. Due to their mechanism of action, they have been associated with immune related adverse events (Ir-AE), including musculoskeletal manifestations. Aim: To assess a) the prevalence,...
2020 / Dimitrios Daoussis, Konstantinos Melissaropoulos, Theodoros Dimitroulas, Haralambos Andreadis, Athina Christopoulou, George Douganiotis, Thomas Makatsoris, Angelos Koutras, Panagiotis Georgiou, Haralabos Kalofonos -
High Fat Diet, Metabolic Syndrome and Systemic Lupus Erythematosus: A Causal Loop2020 / Carlo Perricone, Fulvia Ceccarelli
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Modified Diet Use in Adults with Temporomandibular Disorders related to Rheumatoid Arthritis: A Systematic Review
Objective: Individuals presenting with rheumatoid arthritis (RA) frequently experience temporomandibular disorders (TMDs), which can result in limited ranges of mandibular motion, pain and fatigue on jaw function, and impaired mastication. As such, individuals with RA-related TMDs may consume a...
2020 / Órla Gilheaney, Sibylle Béchet, Margaret Walshe -
The Effect of Omega-3 Fatty Acids on Rheumatoid Arthritis
Omega-3 fatty acids are unsaturated fatty acids thought to play a role in health and disease. They are known as essential fatty acids, as they cannot be synthesized in mammals. Omega-3 fatty acids have a beneficial effect on the secondary prevention of coronary artery disease and stroke and are...
2020 / Ifigenia Kostoglou-Athanassiou, Lambros Athanassiou, Panagiotis Athanassiou -
Infections in Patients with Rheumatoid Arthritis in the Era of Targeted Synthetic Therapies
The third decade of the 21st century marks the beginning of a new era in the treatment of rheumatoid arthritis (RA). Recently, after the introduction in clinical practice of different biologics in the first decade, three different oral synthetic targeted agents (JAK inhibitors) have been licensed...
2020 / Konstantinos Thomas, Dimitrios Vassilopoulos -
Therapeutic targeting of JAKs: from hematology to rheumatology and from the first to the second generation of JAK inhibitors
Several cytokines and growth factors, as well as their downstream signalling pathways, are implicated in the pathogenesis of haematological and immune-mediated diseases. These mediators act through binding to their cognate receptor and activation of one or more of the four Janus family tyrosine...
2020 / George Bertsias -
Under Development JAK Inhibitors for Dermatologic Diseases
Molecular targeting therapies represent a new exciting era in dermatology. A promising novel drug class, subject of intense research, is Janus kinase (JAK) inhibitors. Multiple cytokine receptors signal through the Janus kinase and signal transducer and activator of transcription (STAT) pathway....
2020 / Nikolaos Sideris, Efstratios Vakirlis, Aikaterini Tsentemeidou, Alexandra Kourouklidou, Demetrios Ioannides, Elena Sotiriou -
Beyond Methotrexate and Biologics in RA – Efficacy of JAK Inhibitors and their Place in the Current Treatment Armamentarium2020 / Katerina Chatzidionysiou
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Basic Mechanisms of JAK Inhibition2020 / Chung Ma Lin, Faye Ah Cooles, John D. Isaacs
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Pain in Rheumatoid Arthritis: Could JAK Inhibition be the Answer?2020 / Puja Mehta, Peter C. Taylor
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Updated Greek Rheumatology Society Guidelines for the Management of Rheumatoid Arthritis2020 / Dimitrios Vassilopoulos, Spiros Aslanidis, Dimitrios Boumpas, George Kitas, Spyridon N. Nikas, Dimos Patrikos, Petros P. Sfikakis, Prodromos Sidiropoulos
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Nutritional Pearls: Diet and Rheumatoid Arthritis
Various studies have investigated the effect of diet on rheumatoid arthritis (RA) as a complimentary treatment along with standard drug therapy. Various types of diet have been investigated. Fasting, the Mediterranean diet, the Cretan Mediterranean diet, vegetarian diet, an anti-inflammatory diet...
2020 / Panagiotis Athanassiou, Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou -
Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE)
The term “age-associated B cells” (ABCs) refers to a heterogeneous B cell subset (CD19+,CD21-, CD11c+,T-bet+) which is expanded in the elderly, but also accumulates prematurely in patients with autoimmune disorders and/or infectious diseases. In healthy individuals, ABCs represent a low prevalence...
2020 / Athanasios Sachinidis, Konstantinos Xanthopoulos, Alexandros Garyfallos -
Mitophagy Balance in Various Cell Subsets in Patients with ANCA-Associated Vasculitis and Correlation with the Presence of Anti-Neutrophil Cytoplasmic Antibodies
ANCA-associated vasculitides (AAVs) are characterised by heterogeneous molecular and pathophysiological traits, causing ambiguous differential diagnosis and taxonomy. Response to therapy has proven far from successful, contributing to high mortality. Transcriptome analysis of different vasculitis...
2020 / Aggelos Banos, Konstantinos Thomas, Panagiotis Garantziotis, Nikos Malissovas, Anastasia Filia, Antigoni Pieta, Dionysios Nikolopoulos, Savina Moustafa, Alexandros Panagiotopoulos, Dimitrios T. Boumpas, Dimitrios Vassilopoulos
