Фундаментальная медицина список научных статей
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Combined use of pulse therapy and molecular hydrogen in rats with experimental rheumatoid arthritis: Clinical and histological evaluation of therapeutic effectiveness
Introduction: Glucocorticosteroid therapy is the basic therapeutic option for rheumatoid arthritis; however, long-term treatment with low and medium doses is associated with the development of negative side effects. As reported, oxidative stress is crucial in the pathogenesis of rheumatoid...
2023 / Tatyana A. Berezhnova, Viktoriya V. Shishkina, Dmitry I. Esaulenko, Yelena A. Lunyova, Yelena S. Goryushkina, Angelina A. Abramyan, Kseniya S. Dyadina, Anastasia I. Chechelnitsky, Tatiana V. Samoilenko -
Development and validation of a quantitative HPLC/MS/MS method for the determination of piperacillin in blood plasma
Introduction: Reduced mortality in patients with sepsis taking piperacillin is possible when they receive a long-term infusion, which improves the effect of antimicrobials. However, such piperacillin therapy requires therapeutic drug monitoring, the use of the latest analytical equipment and...
2023 / Vladimir I. Petrov, Ivan S. Anikeev, Tatyana E. Zayachnikova, Andrey V. Strygin, Anna M. Dotsenko -
Empirical determination of the degree of analgesic activity of some new 3-aminothieno[2,3-b]pyridines and 1,4-dihydropyridines based on a complex criterion
Introduction: It is revelant to solve the problem of anesthesia based on the research of new highly effective and safe medicines. Among modern studies, the preparation of heterocyclic compounds starting from cyanothioacetamide with analgesic and anti-inflammatory activities is of considerable...
2023 / Igor V. Bibik, Elena Yu. Bibik, Konstantin A. Frolov, Sergey G. Krivokolysko, Victor V. Dotsenko, Andrey A. Pankov -
Correction of renal ischemia/reperfusion injury with the Combination of Infliximab and the erythropoietin-derived peptide mimetic pHBSP
Introduction: Due to the high social and economic value of acute kidney injury, the scientific community is focused on methods of diagnosis and treatment of this pathology. A number of studies have already revealed cytoprotective effects of the helix B–derived erythropoietin peptide and infliximab...
2023 / Aleksandr S. Netrebenko -
Investigation of wound healing activity of the flavonoid schaftoside isolated from Lychnis chalcedonica
Introduction: This article studies the wound healing activity of the flavonoid schaftoside – apigenin -6-C-βD glucopyranosyl 8-C-α-L arabinopyranoside (C26H28O14) isolated from the above-ground part of Lyсhnis chalcedonica L. Materials and Methods: The experiments were carried out on sexually...
2023 / Tatiana N. Povetyeva, Olga G. Afanasyeva, Larisa N. Zibareva, Yulia V. Nesterova, Nikolay I. Suslov, Pavel V. Kulpin, Gleb N. Zyuz'Kov, Svetlana G. Krylova, Olesya V. Vsyakikh -
Method for obtaining supramolecular complex based on 3-ohypyridine derivatives and its application for correction of osteoporosis
Introduction: Currently, there are no safe and ideal medicines for the prevention and treatment of oophorectomy-induced osteoporosis. The development of an effective pharmacotherapy for hypoestrogeninduced osteoporosis is an important task of pharmacology. Materials and Methods: A new...
2023 / Konstantin S. Trunov -
Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes
Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications. GABA acts as an inhibitory neurotransmitter in the central nervous system and as an extracellular signaling molecule in pancreatic islets,...
2023 / Ivan N. Tyurenkov, Dmitry A. Bakulin, Yulia I. Velikorodnaya, Alexander V. Borisov, Elizaveta E. Abrosimova, Alexey V. Smirnov, Grigoriy L. Snigur, Svyatoslav S. Surin, Daria A. Kavalerova, Olga S. Vasilyeva -
Effective wound healing agents based on N-alkenylimidazole zinc complexes derivatives: future prospects and opportunities
Introduction: The therapeutic effect of commercially available domestic and foreign drugs for the treatment of various skin injuries is far from optimal. These drugs have no universal effects, but cause pronounced side reactions. There is a clear demand for development of innovative wound-healing...
2023 / Svetlana A. Lebedeva, Pavel A. Galenko-Yaroshevsky Jr., Tatiana V. Fateeva, Sergey S. Pashin, Nataliya R. Pashina, Irina B. Nektarevskaya, Andrey V. Zadorozhniy, Olga V. Shelemekh, Marina Yu. Ravaeva, Elena N. Chuyan, Lusine O. Alukhanyan, Tereza R. Glechyan, Kerim Mutig, Maria Yu. Materenchuk -
Method of detection of dexamethasone in biological tissues and its application to assess the local kinetics of this drug
Introduction: The study of the pharmacokinetics of glucocorticosteroids is often required to solve fundamental and applied tasks of pharmacology. HPLC methods based on ultraviolet detection are attractive due to their availability, but their sensitivity is low enough to study in vivo kinetics. In...
2023 / Dina V. Yunina, Valentin P. Ageev, Andrey V. Zaborovskiy, Larisa A. Tararina, Sergei V. Tsaregorodtsev, Alexander V. Kokorev, Dmitry N. Andreev, Aleksandra E. Pyanzina, Vasilisa I. Shlyapkina, Nikolay A. Pyataev, Oleg A. Kulikov -
The effect of zinc complex of N-isopropenylimidazole on the morphological characteristics of gum tissues in experimental endodontic-periodontal lesions in rats
Introduction: Combined inflammatory and destructive processes affecting the dental pulp and tissues of the periodontal complex are among the most problem diseases of the dental system. Current therapy with use of available pharmacological agents does not always allow achieving the expected positive ...
2023 / Pavel A. Galenko-Yaroshevsky, Aleksandr А. Slavinskiy, Sergey S. Todorov, Viktor L. Popkov, Olga V. Shelemekh, Svetlana A. Lebedeva, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Lusine O. Alukhanyan, Irina B. Nektarevskaya, Natalia D. Bunyatyan, Aleksandr А. Verevkin -
Modeling experimental glaucoma for screening studies of antiglaucomatous activity
Introduction: In vivo screening studies, in which the efficacy of dozens of drugs is tested to select several applicants for further study of their safety in humans, are the main stage in the study of the pharmacodynamics of promising antiglaucoma drugs. This imposes a number of specific...
2023 / Koivanvladimir N. Fedorov, Mikhail K. Korsakov, Vladimir P. Vdovichenko, Salavat S. Suleimanov, Alena N. Tyushina, Anastasiya A. Popova -
ЗДОРОВЬЕ НАСЕЛЕНИЯ В ОТДЕЛЬНЫХ НАСЕЛЁННЫХ ПУНКТАХ ВИЛЮЙСКОЙ ГРУППЫ РАЙОНОВ ЯКУТИИ2023 / Тимофеев Леонид Фёдорович, Петрова Пальмира Георгиевна, Борисова Наталья Владимировна, Тимофеев Артём Леонидович
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ОСОБЕННОСТИ ТЕМПЕРАМЕНТА ЛИЦ, СКЛОННЫХ К СОСТОЯНИЮ ФРУСТРАЦИИ
В работе представлено исследование двух групп субъектов: зависимых и независимых (здоровых); – оценка уровня фрустрации в двух группах испытуемых зависимых и независимых (здоровых) и проведение сопоставительного анализа уровня фрустрации в двух группах. Оценка темпераментальных свойств в группах...
2023 / Иуан С.Н. -
KICHIK MAKTAB YOSHIDAGI O’QUVCHILARDA DIQQATNING RIVOJLANISHIGA O’YIN FAOLIYATINI TA’SIRI
Kichik maktab Yoshidagi bolalarning aqliy rivojlanishi o‘qish faoliyati kichik maktab. Yoshidagi o‘quvchining aql-idroki, sezgirligi, kuzatuvchanligi, eslab qolish va esga tushirish imkoniyatlarining rivojlanishi uchun muhim shart-sharoitlar yaratadi, hisoblash malakalarini shakllantiradi.
2023 / Umarova Gulhayo Murodiljon Qizi -
MAKTABGACHA TA’LIMDA MILLIY QADRIYATLAR ASOSIDA TARBIYALASHNING XORIJIY TAJRIBASI
Maqolada maktabgacha ta’lim tashkiloti tarbiyalanuvchilarini milliy qadriyatlar ruhida tarbiyalash, turli xil didaktik materiallar asosida ilmiy-nazariy jihatdan bilim berish o‘rganildi va tahlil qilindi. Shuningdek, xorijiy davlat Maktabgacha ta’lim tashkilotlari imkoniyatlari ham bayon etildi.
2023 / Adxamjon Abdurashidov -
ISOLATION OF TANNINS PISTACIA VERA
The chemical composition of the leaves of Pistacia vera has been studied for the first time. Plant material was successively extracted with chloroform and 70% acetone. The acetone extract was distilled off on a rotary evaporator to an aqueous residue. The aqueous portion was then fractionated with...
2023 / R. Makhmudov, G. Suleymanova, N. Alimkhodzhayeva, M. Dadakhodzhayeva -
SYNTHESIS OF Cu (II), Co (II), Mn (II) COMPLEX COMBINES WITH ASPARAGIN ACID AND DETERMINATION OF THEIR MEDICAL-BIOLOGICAL PROPERTIES
Geometrically isomeric coordination compounds of Cu(II), Co(II), Mn(II) with asparagin acid have been synthesized, competitive coordination of asparagin acid donor atoms to metal ions has been revealed, the conditions for the transformation of some isomers into others have been studied, and medical ...
2023 / N. Alimkhodzhaeva, G. Suleymanova, Z. Ikramova, M. Kadyrov -
DEVELOPMENT OF A COMPLEX TECHNOLOGY FOR OBTAINING IMPORTED BRUCITE BASED ON DEHKHANABAD DOLOMITE MINERAL AND OBTAINING MAGNESIUM BINDERS BASED ON THEM
This article presents a complex laboratory technology for the production of expensive imported magnesium hydroxide (Brucite) from cheap dolomite, which is a local raw material in Uzbekistan, as well as gypsum, alabaster, and mineral fertilizer ammonium sulfate, which is used in construction, and...
2023 / Sh. Tursunov, G. Ikhtiyarova -
CANCER GENESIS: POSSIBLE MECHANISMS OF ITS DEVELOPMENT AND INHIBITION
In this article the changes that may occur during transformation of malignant are analyzed and developed its further theories and novelties around the discussed topic
2023 / S. Ikramova -
IMPROVING THE DIAGNOSIS OF ABNORMAL UTERINE BLEEDING IN WOMEN OF REPRODUCTIVE AGE
In this article, the improvement of the diagnosis of abnormal uterine bleeding in women of reproductive age, the etiology of abnormal uterine bleeding (AUB) may be related to coagulopathy, extragenital causes, and the significant age gradation of the prevalence of (AUB) are presented.
2023 / M. Asadova