Фундаментальная медицина список научных статей
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PEGylation of antibiotic enrofloxacin and its effects on the state of the antioxidant system in rats
The antibiotic enrofloxacin's molecular structure has reactive carboxyl groups used for chemical modification and obtained a PEGylated form of enrofloxacin. For this, the nanopolymer polyethylene glycol-400 (PEG-400) fragments were introduced into the molecule of enrofloxacin at the carboxyl group...
2021 / O.M. Zelenina, V.V. Vlizlo, D.D. Ostapiv, V.Ja. Samaryk, I.A. Dron, M.P. Kozak, N.V. Kuzmina, B.O. Chernushkin, I.A. Maksymovych, M.I. Leno, V.I. Rusyn, O.I. Prystupa, V.L. Fedorovych, B.O. Lukashchuk, H.O. Zinko -
COPING SPACE TRANSFORMATION AT DIFFERENT LEVELS OF UNIVERSITY TRAINING DURING THE PANDEMIC AND THE ASSESSMENT OF ITS INTEGRAL INDICATORS
The impact of the pandemic on mental health is top of the research agenda in various regions of the world. Of particular interest are the methods that allow people to cope with difficulties. University students are a subgroup (along with the elderly and medical staff) that was found to have a...
2022 / Vergunov Eugeny G. -
РОЛЬ НЕЙРОТРОФИЧЕСКОГО ФАКТОРА МОЗГА (BDNF) В ФИЗИЧЕСКОЙ АКТИВНОСТИ (ОБЗОР)
Обзор посвящен описанию одного из нейротрофических факторов мозга (BDNF) и его роли в физической активности человека. В работе говорится, что это белок, обнаруживаемый во многих областях мозга (например, кора гиппокамп). Приводятся доказательства участия этого белка в процессе развития (например, в ...
2022 / Сутормина Надежда Владимировна -
КВАНТОВО-ХИМИЧЕСКОЕ ИССЛЕДОВАНИЕ ЭЛЕКТРОННОГО СТРОЕНИЯ ОНКОЛОГИЧЕСКОГО ПРЕПАРАТА КСЕЛОДА
Электронное строение молекулы препарата Xeloda (5’-диокси-5-фтор-N-[(пентилоксил)карбонил]цитидин, или под CAS названием капецитабин изучено современным квантово-химическим методом DFT B3LYP. На основе анализа рассчитанной геометрии, зарядового распределения и энергетических характеристик оценена...
2022 / Мамарахмонов Мухаматдин Хомидович, Аскаров Ибрагим Рахманович -
Assessment of the level of sex hormones in the blood of domestic animals when using contraceptives
Many methods and tools are used to control sexual function in dogs and cats. However, there are many unresolved issues related to the diagnosis of changes in the reproductive system of animals, multiplicity, dosage and method of contraception, development of innovative methods of reproductive...
2021 / A.P. Paliy, E.A. Dotsenko, L.M. Kovalenko, A.V. Telyatnikov, K.O. Rodionova, I.V. Nikolenko, O.V. Matsenko, K.A. Sinyagovskay, M.V. Kazakov, A.P. Palii -
Autogenous vaccines are an effective means of controlling the epizootic process of mastitis in cows
Prevention of mastitis remains one of the most critical problems in dairy farming. The basis of further pathogenesis is the interaction of the macroorganism and the microorganism/s. The infectious process's latent or clinical form should be considered one of the links in the epizootic process. We...
2021 / B.M. Kurtyak, P.K. Boyko, O.P. Boyko, G.V. Sobko, M.S. Romanovych, T.O. Pundyak, Yu.M. Mandygra, B.V. Gutyj -
Ecological and toxicological characteristics of selenium nanocompounds
The toxicity of selenium and probiotic preparations by intragastric administration to laboratory animals (white rats), weight coefficients of their internal organs, hematological parameters of blood were determined. The studies were performed on three groups of white rats, which for thirty days...
2021 / S.I. Tsekhmistrenko, V.S. Bityutskyy, O.S. Tsekhmistrenko, V.M. Kharchishin, N.O. Tymoshok, A.A. Demchenko, M.Ya. Spivak, I.M. Kushnir, O.I. Rozputnyy, V.M. Polishchuk, N.V. Ponomarenko, N.V. Rol, N.M. Prysiazhniuk, I.V. Pertsovyi, T.S. Tokarchuk -
Experimental simulation of tuberculosis and its features in rabbits under conditions of isoniazid and N'-(2-(5-((theophyline-7-yl) methyl)-4-ethyl)-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrozide
The results of morpho-biochemical studies of tuberculosis inflammation in rabbits in an experimental model with comparative isoniazid treatment and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. It was found that subcutaneous administration of...
2021 / A.S. Hotsulia, V.V. Zazharskyi, P.O. Davydenko, O.M. Kulishenko, V.V. Parchenko, I.V. Bushuieva, N.M. Grynchyshyn, B.V. Gutyj, N.V. Magrelo, V.Y. Prysyaznyuk, H.V. Sus, U.M. Vus -
Infectious risks of biofilms on medical implants
Within a biofilm, there is normally a notion of spatial structuring, the microbes live there in 3D and are called adherent cells. Biofilms formed on medical implants pose a serious public health problem and interfere with the functioning of various medical implants as they present a microbial...
2022 / D. Oukid -
Extraction and identification of some metabolites from three Algerian Sahara medicinal plants
Metabolites are widely distributed in plant kingdom and have an ample range of biological properties. Several investigations have reported the medical and insecticidal activties.Thus, the objective of this study is to identify and qualify metabolites of three spontaneous plants:Caroxylon...
2022 / I. Radjai, G. Chakali -
Phytochemical and physicochemical variations in different tea varieties and clones grown at Nthri, Shinkiari, Mansehra Pakistan
Tea belongs to family of Theaceae and most popular drinking beverages of world. Present study was carried out to find out phytochemical and physicochemical analysis of different tea varieties and clone grown at PARC-National Tea and high Value Crops Research Institute, Shinkiari, Mansehra,...
2022 / D. Kamal, G. Mujtabshah, A. Waheed, M. Abbass Khan, N. Ahmed, U. Jadoon, M. Iqbal, A. Lariab Syed, R. Bibi, I. Iqra, A. Qamer, I. Ahmed -
Antibacterial activity and identification by GC/MS of the chemical composition of essential oils of Juniperus phoenecea and Juniperus oxycedrus L. from Western Algeria: Tiaret province
Extraction by hydrodistillation and characterization by GC/MS of essential oils from the aerial part of the two species of the Juniperus genus: Juniperus phoenecea and Juniperus oxycedrus, harvested in the province of Tiaret; showed the presence of seventeen compounds in J. oxycedrus oil, the main...
2022 / A.H.A. Boukhaloua, M. Berrayah, F. Bennabi, A. Ayache, F. Abdeldjebar -
Hormetic responses of durum wheat (Triticum durum desf.) against cadmium stress
The Hormetic dose-response relationships resulting from environmental polluting agents are often characterized by low dose stimulation and high dose inhibition, which confirms as well the general phenomenon of hormesis with a considerable implication related to the ecological risk assessment. In...
2022 / I. Ghozlene, B. Houria, D. Mohammed-Reda, R. Rachid -
The effect of different doses of probiotic feed additives on hematologic indices and morphological structure of individual pig internal organs
In order to improve the digestibility and absorption of feed, metabolic processes, growth and development of animals, increase the resistance of the body immunomodulatory agents, probiotics, prebiotics, combined enzyme-probiotic feed additives are widely used. The purpose of our work was to conduct ...
2020 / M. Zhyla, N. Shkodyak, G. Kotsyumbas, Y. Stronskyi, O. Sobodosh, M. Shkil -
The influence of the preparation “Bendamin” on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure
The purpose of this work was to study the influence of “Bendamin” on the morphological and biochemical indices of rat blood in experimental modeling of heart failure. The investigation were performed on white sexually mature young male-rats of Wistar line weighing 180–200 g, kept at the standard...
2020 / I.S. Varkholiak, B.V. Gutyj -
Emergency contraception using progestin drugs in domestic cats
Today, in conditions of strict quarantine, when it is not always possible to carry out surgery in cats, some methods of emergency drug contraception can be used. Over the years, many contraceptive medications have been developed for companion animals, but many secondary adverse effects have limited ...
2020 / A. Vasetska -
Influence of cadmium on the cellular part of the immune system of young cattle
The article presents the results of research on the effect of cadmium load on the body of young cattle. The negative effect of Cadmium on the liver causes a wide range of pathological changes at different levels of its organization. The impact of heavy metals on the immune system is particularly...
2020 / Y.Y. Lavryshyn, B.V. Gutyj, K.Y. Leskiv, I.I. Hariv, L.H. Yevtukh, V.L. Shnaider -
Antioxidant status of piglets under nitrate-nitrite load and the action of corrective factors
The article presents the results of research on the state of the antioxidant defense system of piglets under nitrate-nitrite toxicosis and the action of corrective factors (methionine, phenarone and methyphene). Nitrate-nitrite load in piglets caused inhibition of the activity of enzymes of the...
2020 / K. Y. Leskiv B. V. Gutyj D. F. Gufriy V. I. Khalak O. G. Demchuk -
Use of plant-derived drugs in the prevention and treatment of dairy cow mastitis
Dairy cow mastitis is one of most seriously diseases affecting dairy herds. The prevention and treatment of this pathology is especially done through antimicrobials, but the increasing antimicrobial resistance of pathogens to this disease may affect the efficiency of conventional drugs. Plant...
2021 / Ping Xu, Hanna Fotina, Tetiana Fotina, Sanhu Wang -
Hematological, immunological and histological changes in guinea pigs in the treatment of microsporia with drugs “Micromar” and “Biogluk”
Microsporia is a common infectious disease in the practice of a veterinarian. This disease carries a risk of human infection because it is anthropozoonotic. The main pathogen Microsporum sanis affects the upper layers of the skin and has the ability to stay on the body of an animal for up to two...
2021 / Y.V. Martyniv, Ya.V. Kisera